Preliminary Study of a Low-Cost Point-of-Care Testing System Using Screen-Printed Biosensors for Early Biomarkers Detection Related to Alzheimer Disease

A low-cost, easy-to-operate, highly sensitive and effective lung cancer diagnostic kit (LCDK) was developed, and can realize non-invasive detection of early-, middle- and late-stage lung cancers using clinical salivary and urine samples.

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A Low-Cost Point-of-Care Testing System for Psychomotor Symptoms of Depression Affecting Standing Balance: A Preliminary Study in India

Depression Research and Treatment ◽

10.1155/2013/640861 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Arindam Dutta ◽

Robins Kumar ◽

Suruchi Malhotra ◽

Sanjay Chugh ◽

Alakananda Banerjee ◽

...

Keyword(s):

Response Time ◽

Point Of Care ◽

Low Cost ◽

Community Dwelling ◽

World Health ◽

Testing System ◽

Point Of Care Testing ◽

Symptoms Of Depression ◽

Average Slope ◽

Psychomotor Symptoms

The World Health Organization estimated that major depression is the fourth most significant cause of disability worldwide for people aged 65 and older, where depressed older adults reported decreased independence, poor health, poor quality of life, functional decline, disability, and increased chronic medical problems. Therefore, the objectives of this study were (1) to develop a low-cost point-of-care testing system for psychomotor symptoms of depression and (2) to evaluate the system in community dwelling elderly in India. The preliminary results from the cross-sectional study showed a significant negative linear correlation between balance and depression. Here, monitoring quantitative electroencephalography along with the center of pressure for cued response time during functional reach tasks may provide insights into the psychomotor symptoms of depression where average slope of the Theta-Alpha power ratio versus average slope of baseline-normalized response time may be a candidate biomarker, which remains to be evaluated in our future clinical studies. Once validated, the biomarker can be used for monitoring the outcome of a comprehensive therapy program in conjunction with pharmacological interventions. Furthermore, the frequency of falls can be monitored with a mobile phone-based application where the propensity of falls during the periods of psychomotor symptoms of depression can be investigated further.

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Point-of-Care Testing-the Key in the Battle against SARS-CoV-2 Pandemic

Micromachines ◽

10.3390/mi12121464 ◽

2021 ◽

Vol 12 (12) ◽

pp. 1464

Author(s):

Florina Silvia Iliescu ◽

Ana Maria Ionescu ◽

Larisa Gogianu ◽

Monica Simion ◽

Violeta Dediu ◽

...

Keyword(s):

Clinical Decision Making ◽

Point Of Care ◽

Low Cost ◽

Diagnostic Testing ◽

Clinical Decision ◽

Rapid Screening ◽

Diagnostic Tools ◽

Point Of Care Testing ◽

Qrt Pcr ◽

User Friendly

The deleterious effects of the coronavirus disease 2019 (COVID-19) pandemic urged the development of diagnostic tools to manage the spread of disease. Currently, the “gold standard” involves the use of quantitative real-time polymerase chain reaction (qRT-PCR) for SARS-CoV-2 detection. Even though it is sensitive, specific and applicable for large batches of samples, qRT-PCR is labour-intensive, time-consuming, requires trained personnel and is not available in remote settings. This review summarizes and compares the available strategies for COVID-19: serological testing, Point-of-Care Testing, nanotechnology-based approaches and biosensors. Last but not least, we address the advantages and limitations of these methods as well as perspectives in COVID-19 diagnostics. The effort is constantly focused on understanding the quickly changing landscape of available diagnostic testing of COVID-19 at the clinical levels and introducing reliable and rapid screening point of care testing. The last approach is key to aid the clinical decision-making process for infection control, enhancing an appropriate treatment strategy and prompt isolation of asymptomatic/mild cases. As a viable alternative, Point-of-Care Testing (POCT) is typically low-cost and user-friendly, hence harbouring tremendous potential for rapid COVID-19 diagnosis.

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Clinical correlation between a point-of-care testing system and laboratory automation for lipid profile

Clinica Chimica Acta ◽

10.1016/j.cca.2015.04.036 ◽

2015 ◽

Vol 446 ◽

pp. 263-266 ◽

Cited By ~ 11

Author(s):

Carlos Eduardo dos Santos Ferreira ◽

Carolina Nunes França ◽

Cassyano Januário Correr ◽

Márcia L. Zucker ◽

Adagmar Andriolo ◽

...

Keyword(s):

Lipid Profile ◽

Point Of Care ◽

Testing System ◽

Laboratory Automation ◽

Clinical Correlation ◽

Point Of Care Testing

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Point-of-Care Systems for Rapid DNA Quantification in Oncology

Tumori Journal ◽

10.1177/030089160809400214 ◽

2008 ◽

Vol 94 (2) ◽

pp. 216-225 ◽

Cited By ~ 5

Author(s):

Marco Bianchessi ◽

Sarah Burgarella ◽

Marco Cereda

Keyword(s):

Point Of Care ◽

Low Cost ◽

Semiconductor Industry ◽

Point Of Care Testing ◽

Lab On Chip ◽

Diagnostic Assays ◽

Care Systems ◽

Point Of Care Systems ◽

The Common ◽

On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

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Electrochemical (Bio)Sensors for Pesticides Detection Using Screen-Printed Electrodes

Biosensors ◽

10.3390/bios10040032 ◽

2020 ◽

Vol 10 (4) ◽

pp. 32 ◽

Cited By ~ 5

Author(s):

Beatriz Pérez-Fernández ◽

Agustín Costa-García ◽

Alfredo de la Escosura- Muñiz

Keyword(s):

Mass Spectrometry ◽

High Performance ◽

Point Of Care ◽

Low Cost ◽

Review Article ◽

Food Control ◽

Food Contaminants ◽

Screen Printed Electrodes ◽

Analytical Tools ◽

Screen Printed

Pesticides are among the most important contaminants in food, leading to important global health problems. While conventional techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) have traditionally been utilized for the detection of such food contaminants, they are relatively expensive, time-consuming and labor intensive, limiting their use for point-of-care (POC) applications. Electrochemical (bio)sensors are emerging devices meeting such expectations, since they represent reliable, simple, cheap, portable, selective and easy to use analytical tools that can be used outside the laboratories by non-specialized personnel. Screen-printed electrodes (SPEs) stand out from the variety of transducers used in electrochemical (bio)sensing because of their small size, high integration, low cost and ability to measure in few microliters of sample. In this context, in this review article, we summarize and discuss about the use of SPEs as analytical tools in the development of (bio)sensors for pesticides of interest for food control. Finally, aspects related to the analytical performance of the developed (bio)sensors together with prospects for future improvements are discussed.

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