The Future Expansion of Patient Groups for Uterus Transplantation

2019 ◽  
pp. 215-218
Author(s):  
Steven Weyers ◽  
Petra De Sutter
Keyword(s):  
Uterus Transplantation ◽  
The Future ◽  
Patient Groups

scholarly journals Uterus Transplantation with Live Donors: Screening Candidates in One French Center

2020 ◽  
Vol 9 (6) ◽  
pp. 2001 ◽  
Author(s):  
Marie Carbonnel ◽  
Aurelie Revaux ◽  
Elena Menzhulina ◽  
Lea Karpel ◽  
Renaud Snanoudj ◽  
...  
Keyword(s):  
International Society ◽  
Limiting Factors ◽  
Second Step ◽  
Initial Screening ◽  
Inclusion Criteria ◽  
Screening Process ◽  
Uterus Transplantation ◽  
Individual Interviews ◽  
Live Donors ◽  
The Future

We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.

scholarly journals Uterine Tissue Engineering and the Future of Uterus Transplantation

2016 ◽  
Vol 45 (7) ◽  
pp. 1718-1730 ◽  
Author(s):  
Mats Hellström ◽  
Sara Bandstein ◽  
Mats Brännström
Keyword(s):  
Tissue Engineering ◽  
Uterine Tissue ◽  
Uterus Transplantation ◽  
The Future

scholarly journals Deceased Donation Uterus Transplantation: A Review

2021 ◽  
Vol 2 (2) ◽  
pp. 140-148
Author(s):  
Natasha Hammond-Browning ◽  
Si Liang Yao
Keyword(s):  
Clinical Trials ◽  
Living Donor ◽  
Living Donation ◽  
First Birth ◽  
Uterus Transplantation ◽  
The Future

Uterus transplantation (UTx) offers women with absolute uterine factor infertility the option to gestate and birth their own biologically related child. The first birth following living donation UTx happened in 2014. The first birth following deceased donation happened in December 2017, with further successes since. Interest in deceased donation UTx is increasing. The authors established a database to track UTx clinical trials and outcomes. Utilising this database and existing literature, this article reviews the first reported cases of deceased donation UTx and outcomes, and drawing upon comparisons with living donor UTx, comments upon the future for this area of reproductive transplantation research. This is the first article to bring together the literature on deceased donation UTx procedures and outcomes.

Delivering high-quality surgical services for the future

2006 ◽  
Vol 88 (8) ◽  
pp. 260-261
Author(s):  
Dermot O'Riordan ◽  
Jo Cripps
Keyword(s):  
Primary Care Trust ◽  
Working Party ◽  
High Quality ◽  
Chief Executives ◽  
Initial Report ◽  
Reform Agenda ◽  
Surgical Services ◽  
Consultation Document ◽  
The Future ◽  
Patient Groups

In March 2006 the reconfiguration working party published its initial report Delivering High-quality Surgical Services for the Future. This consultation document looked at the key reform dilemmas in the 'new NHS' and set out some potential future areas of work for the College. It was disseminated widely to surgeons, service planners, Trust, strategic health authority and Primary Care Trust chief executives and patient groups. The consultation closed on 30 June 2006 and the responses are being considered by the working party. This article examines the key features of the consultation responses and looks to the future, at how the College will take the reform agenda forward.

scholarly journals Treatment of Hypogonadism: Current and Future Therapies

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 68 ◽  
Author(s):  
Arthi Thirumalai ◽  
Kathryn E. Berkseth ◽  
John K. Amory
Keyword(s):  
Androgen Receptor ◽  
Side Effects ◽  
Alternative Therapies ◽  
Male Hypogonadism ◽  
Selective Androgen Receptor Modulators ◽  
The Future ◽  
Patient Groups ◽  
Receptor Modulators

The treatment of hypogonadism in men is of great interest to both patients and providers. There are a number of testosterone formulations currently available and several additional formulations under development. In addition, there are some lesser-used alternative therapies for the management of male hypogonadism, which may have advantages for certain patient groups. The future of hypogonadism therapy may lie in the development of selective androgen receptor modulators that allow the benefits of androgens whilst minimizing unwanted side effects.

scholarly journals The Future of Human Uterus Transplantation

2014 ◽  
Vol 10 (4) ◽  
pp. 455-467 ◽  
Author(s):  
Liza Johannesson ◽  
Pernilla Dahm-Kähler ◽  
Saskia Eklind ◽  
Mats Brännström
Keyword(s):  
Human Uterus ◽  
Uterus Transplantation ◽  
The Future

International determination of the total motion of the pole

1961 ◽  
Vol 13 ◽  
pp. 29-41
Author(s):  
Wm. Markowitz
Keyword(s):  
Secular Motion ◽  
The Future

A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).

Status of the Lick Proper Motion Program

1978 ◽  
Vol 48 ◽  
pp. 387-388
Author(s):  
A. R. Klemola
Keyword(s):  
Proper Motion ◽  
The Future

Second-epoch photographs have now been obtained for nearly 850 of the 1246 fields of the proper motion program with centers at declination -20° and northwards. For the sky at 0° and northward only 130 fields remain to be taken in the next year or two. The 270 southern fields with centers at -5° to -20° remain for the future.

Some Structural Features of Metaphase Chromosomes of Mice and Men

1967 ◽  
Vol 25 ◽  
pp. 190-191
Author(s):  
Godfrey C. Hoskins ◽  
Betty B. Hoskins
Keyword(s):  
Electron Microscopy ◽  
Electron Micrographs ◽  
Structural Features ◽  
Metaphase Chromosomes ◽  
The Future ◽  
Of Mice And Men ◽  
Mouse Cells ◽  
Human And Mouse

Metaphase chromosomes from human and mouse cells in vitro are isolated by micrurgy, fixed, and placed on grids for electron microscopy. Interpretations of electron micrographs by current methods indicate the following structural features.Chromosomal spindle fibrils about 200Å thick form fascicles about 600Å thick, wrapped by dense spiraling fibrils (DSF) less than 100Å thick as they near the kinomere. Such a fascicle joins the future daughter kinomere of each metaphase chromatid with those of adjacent non-homologous chromatids to either side. Thus, four fascicles (SF, 1-4) attach to each metaphase kinomere (K). It is thought that fascicles extend from the kinomere poleward, fray out to let chromosomal fibrils act as traction fibrils against polar fibrils, then regroup to join the adjacent kinomere.

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