Cox-2 and Cancer Chemoprevention: Picking up the Pieces

2007 ◽  
pp. 73-78 ◽  
Author(s):  
Monica M. Bertagnolli
Keyword(s):  
Cancer Chemoprevention ◽  
Cox 2

scholarly journals COX-2 Called Paradigm for Future of Cancer Chemoprevention

2004 ◽  
Vol 26 (13) ◽  
pp. 36-43
Author(s):  
Rabiya S. Tuma
Keyword(s):  
Cancer Chemoprevention ◽  
Cox 2

COX-2 inhibitors and colorectal cancer chemoprevention

2002 ◽  
Vol 6 (2) ◽  
pp. 31-35 ◽  
Author(s):  
James Hok-Leung Tsu ◽  
Judy Wai-Chu Ho
Keyword(s):  
Colorectal Cancer ◽  
Cancer Chemoprevention ◽  
Cox 2 ◽  
Cox 2 Inhibitors

COX-2 as a molecular target of colon cancer chemoprevention: Promise and reality

2012 ◽  
Vol 2 (3) ◽  
pp. 67-72 ◽  
Author(s):  
Jasmeet Kaur ◽  
Vivek Vaish ◽  
Sankar Nath Sanyal
Keyword(s):  
Colon Cancer ◽  
Cancer Chemoprevention ◽  
Molecular Target ◽  
Cox 2

Dual regulation of IGF-1 receptor expression by COX-2 and angiotensin II in colon cancer cells: A possible implication for cancer chemoprevention

2001 ◽  
Vol 120 (5) ◽  
pp. A594
Author(s):  
Masakazu Yasumaru ◽  
Shingo Tsuji ◽  
Masahiko Tsujii ◽  
Naoki Kawai ◽  
Arata Kimura ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Angiotensin Ii ◽  
Cancer Cells ◽  
Cancer Chemoprevention ◽  
Receptor Expression ◽  
Colon Cancer Cells ◽  
Cox 2

scholarly journals Oral cancer chemoprevention: COX-2 inhibitor a covenant

2021 ◽  
Vol 7 (4) ◽  
pp. 253
Author(s):  
Shashi Keshwar ◽  
Sonal Grover ◽  
Daya Shankar ◽  
Deependra Prasad Sarraf
Keyword(s):  
Oral Cancer ◽  
Cancer Survival ◽  
Cancer Chemoprevention ◽  
Premalignant Lesions ◽  
Treatment Modalities ◽  
Anti Cancer ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors ◽  
The Relationship

<p>Oral cancer survival remains poor despite advancement in treatment modalities. In oral cancer and oral premalignant lesions, cyclooxygenase-2 (COX-2) is widely expressed and tends to be enhanced especially in high-risk oral lesions. Numerous researches suggests that the inflammation pathway of cyclooxygenase/prostaglandin E2 (PGE2) leads to the development and progression of a number of cancers, including oral squamous cell carcinoma (OSCC). With an emphasis on research data, this article discusses the relationship between inflammation and cancer, summarizes the use of anti-inflammatory agents COX-2 inhibitors for cancer chemoprevention and treatment, and explains the mechanisms underlying the anti-cancer effects of anti-inflammatory agents (COX-2 inhibitors).</p>

996 COX-2 INHIBITION FOR PROSTATE CANCER CHEMOPREVENTION: RANDOMIZED PRE-PROSTATECTOMY TRIAL OF CELECOXIB VERSUS PLACEBO

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Jason Flamiatos ◽  
Tomasz Beer ◽  
Nicole Janeba ◽  
Kristi Eilers ◽  
Wei Tian ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Chemoprevention ◽  
Cox 2

Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention

2005 ◽  
Vol 23 (2) ◽  
pp. 254-266 ◽  
Author(s):  
Andrew J. Dannenberg ◽  
Scott M. Lippman ◽  
Jason R. Mann ◽  
Kotha Subbaramaiah ◽  
Raymond N. DuBois
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Research Evidence ◽  
Growth Factor Receptor ◽  
Cancer Chemoprevention ◽  
Cyclooxygenase 2 ◽  
Natural Substances ◽  
Epidermal Growth ◽  
Cox 2

Understanding the mechanisms underlying carcinogenesis provides insights that are necessary for the development of therapeutic strategies to prevent cancer. Chemoprevention, the use of drugs or natural substances to inhibit carcinogenesis, is a rapidly evolving aspect of cancer research. Evidence is presented that cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) are potential pharmacologic targets to prevent cancer. In this paper, we review key data implicating a causal relationship between COX-2, EGFR, and carcinogenesis and possible mechanisms of action. We discuss evidence of crosstalk between COX-2 and EGFR in order to strengthen the rationale for combination chemoprevention, and review plans for a clinical trial that will evaluate the concept of combination chemoprevention targeting COX-2 and EGFR.

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