Angiogenesis and Vascular Morphogenesis

2008 ◽  
pp. 80-88
Author(s):  
Mélanie Héroult ◽  
Yvonne Reiss ◽  
Hellmut G. Augustin
Keyword(s):  
Vascular Morphogenesis

Lasertechniques treatment of vascular malformations

Phlebologie ◽  
2010 ◽  
Vol 39 (03) ◽  
pp. 167-175
Author(s):  
M. Poetke ◽  
P. Urban ◽  
H.-P. Berlien
Keyword(s):  
Endothelial Cells ◽  
Spontaneous Regression ◽  
Vascular System ◽  
Vascular Malformations ◽  
Clinical Importance ◽  
Vascular Structure ◽  
Laser Application ◽  
Vascular Morphogenesis ◽  
Structural Abnormalities

SummaryVascular malformations are structural abnormalities, errors of vascular morphogenesis, which can be localized in all parts of the vascular system. All vascular malformations by definition, are present at birth and grow proportionately with the child; their volume can change. In contrast to the haemangiomas, which only proliferate from the endothelial cells the division in stages is of clinical importance. Vascular malformations are divided from the part of vascular system, which is affected.In principle the techniques of laser application in congenital vascular tumours like haemangiomas and in vascular malformations are similar, but the aim is different. In tumours the aim is to induce regression, in vascular malformations the aim is to destroy the pathologic vascular structure because there is no spontaneous regression. This means that the parameters for treatment of vascular malformations must be more aggressive than for vascular tumours.

scholarly journals Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

2021 ◽  
Author(s):  
Tevin CY. Chau ◽  
Sungmin Baek ◽  
Baptiste Coxam ◽  
Renae Skoczylas ◽  
Maria Rondon‐Galeano ◽  
...  
Keyword(s):  
Vascular Morphogenesis

scholarly journals Sox17 is required for normal pulmonary vascular morphogenesis

2014 ◽  
Vol 387 (1) ◽  
pp. 109-120 ◽  
Author(s):  
Alexander W. Lange ◽  
Hans Michael Haitchi ◽  
Timothy D. LeCras ◽  
Anusha Sridharan ◽  
Yan Xu ◽  
...  
Keyword(s):  
Vascular Morphogenesis

scholarly journals The first “Slit” is the deepest: the secret to a hollow heart

2008 ◽  
Vol 182 (2) ◽  
pp. 221-223 ◽  
Author(s):  
Iiro Taneli Helenius ◽  
Greg J. Beitel
Keyword(s):  
Cell Shape ◽  
Vascular System ◽  
Hollow Heart ◽  
Autocrine Signaling ◽  
Lumen Formation ◽  
Membrane Surfaces ◽  
Vascular Morphogenesis ◽  
Cell Biol ◽  
Shape Changes

Tubular organs are essential for life, but lumen formation in nonepithelial tissues such as the vascular system or heart is poorly understood. Two studies in this issue (Medioni, C., M. Astier, M. Zmojdzian, K. Jagla, and M. Sémériva. 2008. J. Cell Biol. 182:249–261; Santiago-Martínez, E., N.H. Soplop, R. Patel, and S.G. Kramer. 2008. J. Cell Biol. 182:241–248) reveal unexpected roles for the Slit–Robo signaling system during Drosophila melanogaster heart morphogenesis. In cardioblasts, Slit and Robo modulate the cell shape changes and domains of E-cadherin–based adhesion that drive lumen formation. Furthermore, in contrast to the well-known paracrine role of Slit and Robo in guiding cell migrations, here Slit and Robo may act by autocrine signaling. In addition, the two groups demonstrate that heart lumen formation is even more distinct from typical epithelial tubulogenesis mechanisms because the heart lumen is bounded by membrane surfaces that have basal rather than apical attributes. As the D. melanogaster cardioblasts are thought to have significant evolutionary similarity to vertebrate endothelial and cardiac lineages, these findings are likely to provide insights into mechanisms of vertebrate heart and vascular morphogenesis.

scholarly journals Endothelial lumen signaling complexes control 3D matrix–specific tubulogenesis through interdependent Cdc42- and MT1-MMP–mediated events

Blood ◽  
2010 ◽  
Vol 115 (25) ◽  
pp. 5259-5269 ◽  
Author(s):  
Anastasia Sacharidou ◽  
Wonshill Koh ◽  
Amber N. Stratman ◽  
Anne M. Mayo ◽  
Kevin E. Fisher ◽  
...  
Keyword(s):  
Tube Formation ◽  
Dominant Negative ◽  
Collagen Matrices ◽  
Signaling Complex ◽  
Vascular Morphogenesis ◽  
Cytoplasmic Tails ◽  
3D Matrix ◽  
Dependent Signal ◽  
3D Collagen ◽  
Membrane Type

Abstract Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)–B and Jam-C, membrane type 1–matrix metalloproteinase (MT1-MMP), and integrin α2β1, which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockade of both Jam-B and Jam-C using antibodies, siRNA, or dominant-negative mutants completely interferes with lumen and tube formation resulting from a lack of Cdc42 activation, inhibition of Cdc42-GTP–dependent signal transduction, and blockade of MT1-MMP–dependent proteolysis. This process requires interdependent Cdc42 and MT1-MMP signaling, which involves Par3 binding to the Jam-B and Jam-C cytoplasmic tails, an interaction that is necessary to physically couple the components of the lumen signaling complex. MT1-MMP proteolytic activity is necessary for Cdc42 activation during EC tube formation in 3D collagen matrices but not on 2D collagen surfaces, whereas Cdc42 activation is necessary for MT1-MMP to create vascular guidance tunnels and tube networks in 3D matrices through proteolytic events. This work reveals a novel interdependent role for Cdc42-dependent signaling and MT1-MMP–dependent proteolysis, a process that occurs selectively in 3D collagen matrices and that requires EC lumen signaling complexes, to control human EC tubulogenesis during vascular morphogenesis.

scholarly journals Embryonic stem cell model systems for vascular morphogenesis and cardiac disorders.

Hypertension ◽  
1993 ◽  
Vol 22 (4) ◽  
pp. 618-629 ◽  
Author(s):  
T Doetschman ◽  
M Shull ◽  
A Kier ◽  
J D Coffin
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Model ◽  
Embryonic Stem ◽  
Model Systems ◽  
Vascular Morphogenesis ◽  
Stem Cell Model ◽  
Cardiac Disorders

scholarly journals Ultrasound patterning technologies for studying vascular morphogenesis in 3D

2016 ◽  
Vol 130 (1) ◽  
pp. 232-242 ◽  
Author(s):  
Eric S. Comeau ◽  
Denise C. Hocking ◽  
Diane Dalecki
Keyword(s):  
Vascular Morphogenesis

scholarly journals Hydrogel Network Dynamics Regulate Vascular Morphogenesis

2020 ◽  
Author(s):  
Zhao Wei ◽  
Rahel Schnellmann ◽  
Sharon Gerecht
Keyword(s):  
Network Dynamics ◽  
Vascular Morphogenesis ◽  
Hydrogel Network

Morphological and molecular aspects of physiological vascular morphogenesis

Angiogenesis ◽  
2009 ◽  
Vol 12 (2) ◽  
pp. 101-111 ◽  
Author(s):  
Domenico Ribatti ◽  
Beatrice Nico ◽  
Enrico Crivellato
Keyword(s):  
Vascular Morphogenesis ◽  
Molecular Aspects
Sign in / Sign up

Export Citation Format

Share Document