The main purpose of the present study was to mathematically integrate different decision support systems to enhance the accuracy of seismic vulnerability mapping in Sanandaj City, Iran. An earthquake is considered to be a catastrophe that poses a serious threat to human infrastructures at different scales. Factors affecting seismic vulnerability were identified in three different dimensions; social, environmental, and physical. Our computer-based modeling approach was used to create hybrid training datasets via fuzzy-multiple criteria analysis (fuzzy-MCDA) and multiple criteria decision analysis-multi-criteria evaluation (MCDA-MCE) for training the multi-criteria evaluation–logistic regression (MCE–LR) and fuzzy-logistic regression (fuzzy-LR) hybrid model. The resulting dataset was validated using the seismic relative index (SRI) method and ten damaged spots from the study area, in which the MCDA-MCE model showed higher accuracy. The hybrid learning models of MCE-LR and fuzzy-LR were implemented using both resulting datasets for seismic vulnerability mapping. Finally, the resulting seismic vulnerability maps based on each model were validation using area under curve (AUC) and frequency ratio (FR). Based on the accuracy assessment results, the MCDA-MCE hybrid model (AUC = 0.85) showed higher accuracy than the fuzzy-MCDA model (AUC = 0.80), and the MCE-LR hybrid model (AUC = 0.90) resulted in more accurate vulnerability map than the fuzzy-LR hybrid model (AUC = 0.85). The results of the present study show that the accuracy of modeling and mapping seismic vulnerability in our case study area is directly related to the accuracy of the training dataset.