Screening for Prostate Cancer: Reflecting on the Quality of Evidence from the ERSPC and PLCO Studies

2014 ◽  
pp. 65-71 ◽  
Author(s):  
Dragan Ilic
Keyword(s):  
Prostate Cancer ◽  
Quality Of Evidence

Conservative management and radical treatment in localised prostate cancer: A systematic review with meta-analysis and trial sequential analysis

2018 ◽  
Vol 12 (3) ◽  
pp. 228-238
Author(s):  
Ka Ting Ng ◽  
Pei En Kwok ◽  
Wan Yi Teoh
Keyword(s):  
Prostate Cancer ◽  
Urinary Incontinence ◽  
Conservative Management ◽  
Odds Ratio ◽  
Distant Metastases ◽  
Quality Of Evidence ◽  
Radical Treatment ◽  
All Cause Mortality ◽  
Related Mortality

Background: Several randomised control trials comparing conservative management (watchful waiting/observation/active monitoring) and radical treatments (radical prostatectomy/radiotherapy) for localised prostate cancer with at least more than 10 years of follow-up (median) have been published with conflicting findings. The primary aim of this study was to determine all-cause mortality and prostate cancer-related mortality between conservative management and radical treatment for localised prostate cancer. Methods: All randomised clinical trials were searched in MEDLINE, EMBASE, PubMed and CENTRAL from their inception until September 2018. Results: Four trials were eligible ( n = 3211) for inclusion in the data synthesis. In patients who had radical treatment, the incidence of all-cause mortality and prostate cancer-related mortality (three trials, 3069 patients) were reduced (with odds ratio, i.e. 95% confidence interval (CI)), of 1.37 (1.14–1.64), ρ < 0.001, low quality of evidence and odd ratio (95% CI) of 1.74 (1.31–2.30), ρ < 0.001, low quality of evidence, respectively). The radical treatment group was associated with reduced incidence of distant metastases, the odds ratio (95% CI) being 1.87 (1.48–2.36), ρ < 0.001, low quality of evidence. However, patients who were randomised to radical treatment had a significantly higher incidence of erectile dysfunction (the odds ratio (95% CI) being 0.62 (0.39–0.98), ρ = 0.04, very low quality of evidence) and urinary incontinence (odds ratio (95% CI) of 0.42 (0.21–0.86), ρ = 0.02, very low quality of evidence). Conclusions: In summary, radical treatments reduce all-cause mortality, and prostate cancer-related and distant metastases, at the expense of higher incidence of erectile dysfunction and urinary incontinence. The general quality of evidence ranged from very low to low. Level of evidence: 1a PROSPERO Registration Number: CRD42017072687

Quality of Evidence for Treatment of Prostate Cancer

JAMA ◽  
2000 ◽  
Vol 284 (14) ◽  
pp. 1785-1786 ◽  
Author(s):  
M. Clarke
Keyword(s):  
Prostate Cancer ◽  
Quality Of Evidence

386: Health Related Quality of Life in Low-Income, Uninsured Men with Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 101-102
Author(s):  
Tracey L. Krupski ◽  
Arlene Fink ◽  
Lorna Kwan ◽  
Sarah Connor ◽  
Sally L. Maliski ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Low Income ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

158: The Impact of Skeletal-Related Events on Preferences and Health-Related Quality of Life of Patients with Metastatic Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 42-42 ◽  
Author(s):  
Kevin P. Weinfurt ◽  
Liana D. Castel ◽  
Yun Li ◽  
Fred Saad ◽  
Justin W. Timbie ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Skeletal Related Events ◽  
The Impact

Quality of Life of men with prostate cancer

2004 ◽  
Author(s):  
A. E. Voerman ◽  
F. Fischer ◽  
A. Visser ◽  
B. Garssen ◽  
G. van Andel
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer

Coaching Teachers to Enhance the Implementation Quality of Evidence-Based Programs

2013 ◽  
Author(s):  
Kimberly D. Becker ◽  
Dana Darney ◽  
Celene Domitrovich ◽  
Catherine Bradshaw ◽  
Nicholas S. Ialongo
Keyword(s):  
Evidence Based ◽  
Implementation Quality ◽  
Quality Of Evidence ◽  
Evidence Based Programs
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