Defect Filling

2003 ◽  
pp. 117-121
Author(s):  
Hans H. Paessler
Keyword(s):  
Defect Filling

scholarly journals Effect of local administration of platelet-rich plasma and guided tissue regeneration on the level of bone resorption in early dental implant insertion

2008 ◽  
Vol 65 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Milos Duka ◽  
Zoran Lazic ◽  
Marija Bubalo
Keyword(s):  
Bone Resorption ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Cellular Migration ◽  
Significant Difference ◽  
The Right ◽  
Defect Filling ◽  
Deproteinized Bone

Background/Aim. Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodeling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. The aim of the research was to test the influence that PRP and guided tissue regeneration in bone defects have on bone defect filling and the level of bone resorption in early implant insertion. Methods. This experimental study included 10 dogs. A total of 40 BCT implants were inserted, 4 in each dog (two on the left side and two on the right side), with guided tissue regeneration. Radiologic analyses were done immediately after the insertion and 10 weeks after the insertion. Bone defect filling was measured by a graduated probe 10 weeks after the implant insertion. The following protocols were tested: I - PRP in combination with bovine deproteinized bone (BDB) and resorptive membrane of bovine origin (RBDM), II - BDB + RBDM, III - PRP + RBDM and IV - RBDM. Results. The applied protocols affected differently the bone defect filling and the level of bone resorption. Significantly better results (the lowest bone resorption) were achieved with protocol I (PRP + BDB + RBDM) in comparison with protocols III (PRP + RBDM) and IV (RBDM), but not with protocol II (BDB + RBDM). On the other hand, no significant difference was found among protocols II (BDB + RBDM), III (PRP + RBDM) and IV (RBDM) in the level of bone tissue resorption. Conslusion. The bone defect filling was largest and the level of bone resorption was lowest in the protocol with PRP applied in combination with BDB and RBDM.

Monte Carlo Simulations of Defect Relaxation in Amorphous Silicon

1995 ◽  
Vol 377 ◽  
Author(s):  
Thomas Unold ◽  
Howard M. Branz
Keyword(s):  
Monte Carlo ◽  
Monte Carlo Simulations ◽  
Amorphous Silicon ◽  
Time Dependent ◽  
Memory Model ◽  
Filling Time ◽  
Defect Filling ◽  
Defect Relaxation ◽  
Structural Memory

ABSTRACTThe structural memory model of slow defect relaxation in a-Si:H is extended to the limit of long defect filling times. The model was proposed in order to explain unusual, defect filling-time dependent capacitance transients that were observed for short defect filling times. For long defect filling pulses however, the experiments show normal charge emission transients that saturate into filling-time independent transients. We present two possibilities for explaining the approach to saturation within the structural memory model. Results of Monte Carlo simulations of the models are discussed.

scholarly journals Engineering a 3D Vascularized Adipose Tissue Construct Using a Decellularized Lung Matrix

Biomimetics ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 52
Author(s):  
Megan K. DeBari ◽  
Wai Hoe Ng ◽  
Mallory D. Griffin ◽  
Lauren E. Kokai ◽  
Kacey G. Marra ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Perfusion Culture ◽  
High Density ◽  
Large Defect ◽  
Subcutaneous White Adipose Tissue ◽  
Lung Matrix ◽  
Tissue Grafts ◽  
First Time ◽  
Defect Filling ◽  
Tissue Construct

Critically sized defects in subcutaneous white adipose tissue result in extensive disfigurement and dysfunction and remain a reconstructive challenge for surgeons; as larger defect sizes are correlated with higher rates of complications and failure due to insufficient vascularization following implantation. Our study demonstrates, for the first time, a method to engineer perfusable, pre-vascularized, high-density adipose grafts that combine patient-derived adipose cells with a decellularized lung matrix (DLM). The lung is one of the most vascularized organs with high flow, low resistance, and a large blood–alveolar interface separated by a thin basement membrane. For our work, the large volume capacity within the alveolar compartment was repurposed for high-density adipose cell filling, while the acellular vascular bed provided efficient graft perfusion throughout. Both adipocytes and hASCs were successfully delivered and remained in the alveolar space even after weeks of culture. While adipose-derived cells maintained their morphology and functionality in both static and perfusion DLM cultures, perfusion culture offered enhanced outcomes over static culture. Furthermore, we demonstrate that endothelial cells seamlessly integrate into the acellular vascular tree of the DLM with adipocytes. These results support that the DLM is a unique platform for creating vascularized adipose tissue grafts for large defect filling.

scholarly journals Incomplete defect filling after third generation autologous chondrocyte implantation

2016 ◽  
Vol 4 ◽  
pp. 785-192 ◽  
Author(s):  
Thomas R. Niethammer ◽  
Matthias F. Pietschmann ◽  
Andreas Ficklscherer ◽  
Mehmet F. Gülecyüz ◽  
Florian Hammerschmid ◽  
...  
Keyword(s):  
Autologous Chondrocyte Implantation ◽  
Third Generation ◽  
Chondrocyte Implantation ◽  
Defect Filling ◽  
Autologous Chondrocyte

A dual functional bone‐defect‐filling material with sequential antibacterial and osteoinductive properties for infected bone defect repair

2019 ◽  
Vol 107 (10) ◽  
pp. 2360-2370 ◽  
Author(s):  
Dongyun Wang ◽  
Yi Liu ◽  
Yuelian Liu ◽  
Liang Yan ◽  
Sebastian A.J. Zaat ◽  
...  
Keyword(s):  
Bone Defect ◽  
Filling Material ◽  
Bone Defect Repair ◽  
Dual Functional ◽  
Defect Repair ◽  
Defect Filling

scholarly journals The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1616
Author(s):  
Mayra Eliana Valencia Zapata ◽  
Carlos David Grande Tovar ◽  
José Herminsul Mina Hernandez
Keyword(s):  
Graphene Oxide ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
High Morbidity ◽  
Bone Cements ◽  
Biomedical Field ◽  
Antibiotic Release ◽  
Defect Filling

Acrylic bone cements (ABC) are widely used in orthopedics for joint fixation, antibiotic release, and bone defect filling, among others. However, most commercially available ABCs exhibit a lack of bioactivity and are susceptible to infection after implantation. These disadvantages generate long-term loosening of the prosthesis, high morbidity, and prolonged and expensive treatments. Due to the great importance of acrylic bone cements in orthopedics, the scientific community has advanced several efforts to develop bioactive ABCs with antibacterial activity through several strategies, including the use of biodegradable materials such as chitosan (CS) and nanostructures such as graphene oxide (GO), with promising results. This paper reviews several studies reporting advantages in bioactivity and antibacterial properties after incorporating CS and GO in bone cements. Detailed information on the possible mechanisms by which these fillers confer bioactive and antibacterial properties to cements, resulting in formulations with great potential for use in orthopedics, are also a focus in the manuscript. To the best of our knowledge, this is the first systematic review that presents the improvement in biological properties with CS and GO addition in cements that we believe will contribute to the biomedical field.

The effect of a slow mode of BMP-2 delivery on the inflammatory response provoked by bone-defect-filling polymeric scaffolds

Biomaterials ◽  
2010 ◽  
Vol 31 (29) ◽  
pp. 7485-7493 ◽  
Author(s):  
Gang Wu ◽  
Yuelian Liu ◽  
Tateyuki Iizuka ◽  
Ernst Bruno Hunziker
Keyword(s):  
Inflammatory Response ◽  
Bone Defect ◽  
Slow Mode ◽  
Polymeric Scaffolds ◽  
Defect Filling

scholarly journals Managing Bony Defects of the Shoulder Joint that Occur in Association with Dislocation

2017 ◽  
Vol 11 (1) ◽  
pp. 1245-1257 ◽  
Author(s):  
Jonathan Brian Yates ◽  
Muhammad Naghman Choudhry ◽  
Mohammad Waseem
Keyword(s):  
Patient Outcomes ◽  
Humeral Head ◽  
Shoulder Joint ◽  
Articular Surface ◽  
Compression Fracture ◽  
Optimal Method ◽  
Treatment Techniques ◽  
Surgical Options ◽  
Defect Filling ◽  
Improve Patient

Background: Defects to the articular surface of the humeral head have been known to be associated with shoulder dislocation since the 19th century. It wasn't until 1934 that the first description of the ubiquitous compression fracture of the posterolateral humeral head that occurs with traumatic anterior instability appeared. From 1940, this defect became referred to as a Hill-Sachs lesion after the investigators who reported the condition. The significance of, and therefore treatment of, these and other such bony defects around the shoulder joint has been hotly debated. Methods: We reviewed the available current literature to determine and report on the most up to date concepts and treatment techniques being used to manage bony defects of the shoulder. Results: Numerous surgical options have been proposed to manage bony defects of the shoulder, including a variety of defect-filling procedures, with good outcomes. However, the small numbers and diversity of case mix makes for difficult comparisons. Conclusion: We are currently developing a greater appreciation of how both the humeral and glenoid defects interact and therefore should be assessed and addressed simultaneously in order to improve patient outcomes. More research and collaboration is needed to determine the optimal method of assessing and managing these patients.

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