scholarly journals Effect of local administration of platelet-rich plasma and guided tissue regeneration on the level of bone resorption in early dental implant insertion

2008 ◽  
Vol 65 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Milos Duka ◽  
Zoran Lazic ◽  
Marija Bubalo
Keyword(s):  
Bone Resorption ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Cellular Migration ◽  
Significant Difference ◽  
The Right ◽  
Defect Filling ◽  
Deproteinized Bone

Background/Aim. Osseointegration is a result of cellular migration, differentiation, bone formation, and bone remodeling on the surface of an implant. Each of these processes depends on platelets and blood coagulum. Platelet-rich plasma (PRP) is used to improve osseointegration and stability of implants. The aim of the research was to test the influence that PRP and guided tissue regeneration in bone defects have on bone defect filling and the level of bone resorption in early implant insertion. Methods. This experimental study included 10 dogs. A total of 40 BCT implants were inserted, 4 in each dog (two on the left side and two on the right side), with guided tissue regeneration. Radiologic analyses were done immediately after the insertion and 10 weeks after the insertion. Bone defect filling was measured by a graduated probe 10 weeks after the implant insertion. The following protocols were tested: I - PRP in combination with bovine deproteinized bone (BDB) and resorptive membrane of bovine origin (RBDM), II - BDB + RBDM, III - PRP + RBDM and IV - RBDM. Results. The applied protocols affected differently the bone defect filling and the level of bone resorption. Significantly better results (the lowest bone resorption) were achieved with protocol I (PRP + BDB + RBDM) in comparison with protocols III (PRP + RBDM) and IV (RBDM), but not with protocol II (BDB + RBDM). On the other hand, no significant difference was found among protocols II (BDB + RBDM), III (PRP + RBDM) and IV (RBDM) in the level of bone tissue resorption. Conslusion. The bone defect filling was largest and the level of bone resorption was lowest in the protocol with PRP applied in combination with BDB and RBDM.

scholarly journals COMPARATIVE CHARACTERISTICS OF VARIOUS TYPES OF MEMBRANES USED FOR BONE GRAFTING AND GUIDED TISSUE REGENERATION IN DENTISTRY AND MAXILLOFACIAL SURGERY

2017 ◽  
Vol 21 (5) ◽  
pp. 291-296
Author(s):  
I. Mecuku ◽  
A. A Muraev ◽  
Julia V. Gazhva ◽  
S. G Ivashkevich
Keyword(s):  
Bone Defect ◽  
Tissue Regeneration ◽  
Bone Grafting ◽  
Maxillofacial Surgery ◽  
Guided Tissue Regeneration ◽  
Dental Practice ◽  
Risk Of Infection ◽  
Professional Literature ◽  
Surgical Wounds ◽  
High Degree

This review aims to analyze the domestic and foreign professional literature, and it shows the main positive and negative properties of the materials for the manufacture of membranes used in modern dental practice in bone-grafting interventions and guided tissue regeneration. Emphasis is placed on the importance of developing a new individual membrane made of polytetrafluorethylene, due to high relevance of such researches owing toreduce the risk of infection of surgical wounds and high degree of adaptation to the geometry of the bone defect.

scholarly journals Effects of local application of platelet-rich plasma and guided tissue regeneration on stability of implants

2010 ◽  
Vol 60 (1) ◽  
pp. 89-101
Author(s):  
Duka Milos ◽  
Lazic Z. ◽  
Bubalo Marija ◽  
Tatic Z. ◽  
Djurdjevic D. ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Local Application

Combined Use of Platelet-Rich Plasma and Bone Grafting With or Without Guided Tissue Regeneration in the Treatment of Anterior Interproximal Defects

2007 ◽  
Vol 78 (5) ◽  
pp. 801-809 ◽  
Author(s):  
Zeynep Yassibag-Berkman ◽  
Ozen Tuncer ◽  
Turkan Subasioglu ◽  
Alpdogan Kantarci
Keyword(s):  
Tissue Regeneration ◽  
Bone Grafting ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Combined Use

Platelet-Rich Plasma and Autogenous Bone Graft Combined with Guided Tissue Regeneration in Periodontal Fenestration Defects in Dogs

2014 ◽  
Vol 34 (6) ◽  
pp. e112-e120 ◽  
Author(s):  
Ilker Keskiner ◽  
Arzu Alkan ◽  
Gokhan Acikgoz ◽  
Nejat Arpak ◽  
Suleyman Kaplan ◽  
...  
Keyword(s):  
Bone Graft ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Autogenous Bone Graft ◽  
Autogenous Bone

scholarly journals In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 599 ◽  
Author(s):  
Chien-Chung Chen ◽  
Sheng-Yang Lee ◽  
Nai-Chia Teng ◽  
Hsin-Tai Hu ◽  
Pei-Chi Huang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Animal Study ◽  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Guided Tissue Regeneration ◽  
In Vivo Studies ◽  
Defect Sites ◽  
Significant Difference ◽  
Bone Height

The guided tissue regeneration (GTR) membrane is a barrier intended to maintain a space for alveolar bone and periodontal ligament tissue regeneration but prevent the migration of fast-growing soft tissue into the defect sites. This study evaluated the physical properties, in vivo animal study, and clinical efficacy of hydrophilic PLA95/β-TCP GTR membranes prepared by electrospinning (ES). The morphology and cytotoxicity of ES PLA95/β-TCP membranes were evaluated by SEM and 3-(4,5-cimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) respectively. The cementum and bone height were measured by an animal study at 8 and 16 weeks after surgery. Fifteen periodontal patients were selected for the clinical trial by using a commercial product and the ES PLA95/β-TCP membrane. Radiographs and various indexes were measured six months before and after surgery. The average fiber diameter for this ES PLA95/β-TCP membrane was 2.37 ± 0.86 µm. The MTT result for the ES PLA95/β-TCP membrane showed negative for cytotoxicity. The significant differences in the cementum and bone height were observed between empty control and the ES PLA95/β-TCP membrane in the animal model (p < 0.05). Clinical trial results showed clinical attachment level (CAL) of both control and ES PLA95/β-TCP groups, with a significant difference from the pre-surgery results after six months. This study demonstrated that the ES PLA95/β-TCP membrane can be used as an alternative GTR membrane for clinical applications.

scholarly journals From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery

2019 ◽  
Vol 13 (02) ◽  
pp. 280-286 ◽  
Author(s):  
Andrea Caruana ◽  
Daniele Savina ◽  
José Paulo Macedo ◽  
Sandra Clara Soares
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Tissue Regeneration ◽  
Second Generation ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Maxillofacial Surgery ◽  
Cellular Migration ◽  
Platelet Concentrates ◽  
Platelet Rich Fibrin

AbstractIn the past 20 years, the platelet concentrates have evolved from first-generation products, i.e., platelet-rich plasma (PRP) and plasma rich in growth factors to the second-generation products such as leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). These autologous products with a higher leukocyte inclusion and flexible fibrin mesh act as a scaffold to increase cellular migration in the angiogenic, osteogenic, and antimicrobial potential of these biomaterials in tissue regeneration. In the second-generation platelet concentrates, the protocols are easier, cheaper, and faster with an entire physiological fibrin matrix, resulting in a tridimensional mesh, not as rigid as one of the first generations. This allows the slow release of molecules over a longer period of time and triggers the healing and regenerative process at the site of injury. The potential of A-PRF to mimic the physiology and immunology of wound healing is also due to the high concentration of growth factors released as follows: vascular endothelial growth factor, platelet-derived growth factor, transforming growth factor-β, and anti-inflammatory cytokines that stimulate tissue cicatrization, vessels formation, and bone cell proliferation and differentiation. Furthermore, the number of neutrophils and monocytes/macrophages is higher releasing important chemotactic molecules such as chemokine ligand-5 and eotaxin. Thus, L-PRF and A-PRF have been used, especially in implantology, periodontology, and maxillofacial surgery. Future clinical applications include tissue regeneration/grafts, ulcers/skin necrosis in the diabetic patient and others, plastic surgery, and even musculoskeletal lesions.

A Surgical Reentry Study on the Influence of Platelet-Rich Plasma in Enhancing the Regenerative Effects of Bovine Porous Bone Mineral and Guided Tissue Regeneration in the Treatment of Intrabony Defects in Humans

2009 ◽  
Vol 80 (6) ◽  
pp. 915-923 ◽  
Author(s):  
Paulo M. Camargo ◽  
Vojislav Lekovic ◽  
Michael Weinlaender ◽  
Tihana Divnic-Resnik ◽  
Marija Pavlovic ◽  
...  
Keyword(s):  
Bone Mineral ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Guided Tissue Regeneration ◽  
Intrabony Defects

scholarly journals Observation on the Effect of Bone Grafting Alone and Guided Tissue Regeneration Combined with Bone Grafting to Repair Periodontal Intraosseous Defects

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yongping Yuan ◽  
Jiajia Zhao ◽  
Nv He
Keyword(s):  
Bone Density ◽  
Bone Defect ◽  
Tissue Regeneration ◽  
Bone Grafting ◽  
Alveolar Bone ◽  
Guided Tissue Regeneration ◽  
Control Group ◽  
Observation Group ◽  
Aesthetic Appearance ◽  
The Aesthetic

Objective. To investigate the curative effect of guided tissue regeneration (GTR) combined with bone grafting and improve the aesthetic appearance of patients’ gingiva. Methods. A total of 86 patients with periodontal intraosseous defects were selected from February 2019 to February 2021. All the patients were divided into a control group and an observation group according to the random number table, with 43 patients in each group. Bone grafting was performed in the control group, while GTR was additionally used in the observation group on the basis of the control group. The surgical data and follow-up data were collected and organized. The alveolar bone mineral density, the change in the height of the bone defect, plaque index (PLI), sulcus hemorrhage index (SBI), PD, gingival recession (GR), clinical attachment loss (CAL), and other relevant data of the two groups in 6 months before and after surgery were compared. Six months after surgery, the cosmetic morphology of the patient's gums in the soft tissues around her teeth was evaluated. Results. Six months after surgery, the alveolar bone density of patients in two groups increased compared with that before surgery, and the height of the bone defect decreased compared with that before surgery. The alveolar bone density of the observation group was higher than that of the control group, and the height of the bone defect was lower than that of the control group ( P < 0.05 ). Six months after surgery, the PLI, SBI, PD, and CAL of patients in both groups were lower than those before surgery, while the GR was higher than that before surgery. PD and CAL values in the observation group were lower than those in the control group, and GR was higher than that in the control group ( P < 0.05 ). Six months after surgery, there was no significant difference in PLI and SBI scores between the two groups ( P < 0.05 ). Six months after surgery, the gingival cosmetic scores of the two groups of patients were higher than those before surgery. The observation group was higher than the control group ( P < 0.05 ). Conclusion. GTR combined with bone grafting has a good effect in the repair of periodontal intraosseous defects and can effectively promote the reconstruction and recovery of periodontal intraosseous defects in patients. At the same time, it can significantly improve the aesthetic appearance of patients’ gums, with good clinical application value.

scholarly journals Effects of local administration of platelet-rich plasma and guided tissue regeneration on bone healing in early inserted dental implants - a histomorphometric analysis

2020 ◽  
Vol 74 (1) ◽  
pp. 34-47
Author(s):  
Milos Duka ◽  
Zoran Lazic ◽  
Marija Bubalo ◽  
Branko Mihailovic ◽  
Milan Miladinovic ◽  
...  
Keyword(s):  
Growth Factors ◽  
Dental Implant ◽  
Tissue Regeneration ◽  
Bone Healing ◽  
Platelet Rich Plasma ◽  
Bone Defects ◽  
Tissue Growth ◽  
Guided Tissue Regeneration ◽  
Bovine Bone ◽  
Implant Loading

Introduction. In order to provide the most favorable conditions for bone healing following implant loading, new techniques such as the use of growth factors to directly or indirectly regulate cell and tissue growth are becoming increasingly popular. Simplicity in producing concentrated thrombocytes derived from platelet-rich plasma has led to increasing application of growth factors derived from thrombocytes, such as PDGF, TGF-?, IGF and VEGF, in order to increase the percentage of bone-to-implant contact that provides better implant stability and possibly earlier functional loading. The aim of the study was to determine the effects of platelet-rich plasma and guided tissue regeneration on bone regeneration in the case of bone defects in early dental implant insertion. Materials and Methods. This experimental study was conducted on 10 study dogs that received 40 BCT implants, i.e., 4 implants per dog. The study included early dental implant placement in the sites of the extracted premolars. Artificial bone defects, resembling peri-implantitis defects, were made on the mesial side of each site, and the defects were filled using suitable guided tissue regeneration protocols with platelet-rich plasma derived from each experimental animal an hour before surgery. Histopathologic and histomorphometric evaluations were performed 10 months following the implantation. Results and Conclusion. The applied protocols had different effects on bone healing. According to the results obtained, the use of platelet-rich plasma combined with deproteinized bovine bone and bovine-derived resorptive membrane provided superior bone defect ossification

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