scholarly journals Infection of Multipotent IL-3-dependent Stem Cells With a Retroviral Vector Containing the IL-3 Gene Confers Density-dependent Growth Autonomy Without Blocking Differentiation

Author(s):  
U. Just ◽  
E. Spooncer ◽  
M. Katsuno ◽  
I. Hampson ◽  
M. Dexter ◽  
...  
Oecologia ◽  
2010 ◽  
Vol 165 (4) ◽  
pp. 959-969 ◽  
Author(s):  
Sigurd Einum ◽  
Grethe Robertsen ◽  
Keith H. Nislow ◽  
Simon McKelvey ◽  
John D. Armstrong

Stem Cells ◽  
2009 ◽  
Vol 27 (2) ◽  
pp. 300-306 ◽  
Author(s):  
Florencio Varas ◽  
Matthias Stadtfeld ◽  
Luisa de Andres-Aguayo ◽  
Nimet Maherali ◽  
Alessandro di Tullio ◽  
...  

1988 ◽  
Vol 8 (2) ◽  
pp. 974-977 ◽  
Author(s):  
L J Smith ◽  
S Benchimol

An amphotropic retroviral vector containing the bacterial neomycin phosphotransferase gene (neo) was used to infect blast cells from patients with acute myeloblastic leukemia. The infected cells acquired a G418-resistant phenotype that was stable as measured in a clonogenic assay and in long-term suspension culture. Thus, gene transfer into stem cells was accomplished by this procedure. This approach for manipulating gene expression in blast stem cells provides a means to assess the roles of a variety of genes in self-renewal, differentiation, and leukemogenesis.


Nature ◽  
1974 ◽  
Vol 250 (5469) ◽  
pp. 739-741 ◽  
Author(s):  
IIH-NAN CHOU ◽  
PAUL H. BLACK ◽  
RICHARD O. ROBLIN

2002 ◽  
Vol 59 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Geir Ottersen ◽  
Kristin Helle ◽  
Bjarte Bogstad

For the large Arcto-Norwegian stock of cod (Gadus morhua L.) in the Barents Sea, year-to-year variability in growth is well documented. Here three hypotheses for the observed inverse relation between abundance and the mean length-at-age of juveniles (ages 1–4) are suggested and evaluated. Based on comprehensive data, we conclude that year-to-year differences in length-at-age are mainly determined by density-independent mechanisms during the pelagic first half year of the fishes' life. Enhanced inflow from the southwest leads to an abundant cohort at the 0-group stage being distributed farther east into colder water masses, causing lower postsettlement growth rates. We can not reject density-dependent growth effects related to variability in food rations, but our data do not suggest this to be the main mechanism. Another hypothesis suggests that lower growth rates during periods of high abundance are a result of density-dependent mechanisms causing the geographic range of juveniles to extend eastwards into colder water masses. This is rejected mainly because year-to-year differences in mean length are established by age 2, which is too early for movements over large distances.


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