What Is Old and What Is New in the Genetics of Endogenous Psychoses?

Author(s):  
E. Zerbin-Rüdin
Keyword(s):  
1989 ◽  
Vol 28 (03) ◽  
pp. 88-91
Author(s):  
J. Schröder ◽  
H. Henningsen ◽  
H. Sauer ◽  
P. Georgi ◽  
K.-R. Wilhelm

18 psychopharmacologically treated patients (7 schizophrenics, 5 schizoaffectives, 6 depressives) were studied using 99mTc-HMPAO-SPECT of the brain. The regional cerebral blood flow was measured in three transversal sections (infra-/supraventricular, ventricular) within 6 regions of interest (ROI) respectively (one frontal, one parietal and one occipital in each hemisphere). Corresponding ROIs of the same section in each hemisphere were compared. In the schizophrenics there was a significantly reduced perfusion in the left frontal region of the infraventricular and ventricular section (p < 0.02) compared with the data of the depressives. The schizoaffectives took an intermediate place. Since the patients were treated with psychopharmaca, the result must be interpreted cautiously. However, our findings seem to be in accordance with post-mortem-, CT- and PET-studies presented in the literature. Our results suggest that 99mTc-HMPAO-SPECT may be helpful in finding cerebral abnormalities in endogenous psychoses.


Solution of the problems of differential diagnosis, treatment and social rehabilitation of patients with endogenous psychoses with episodic course is one of the most complex and urgent problems of clinical psychiatry, which is caused by polymorphism and variability of symptoms, decrease or loss of critical attitude toward the disease, with grave social and economic consequences. The aim of the study is to establish, on the basis of the results of the comparative analysis of the characteristics of the personal profile, the features and nosospecific differences of post-manifest pathopersonаlogical transformations in patients with schizophrenia, schizoaffective disorder and affective disorders in remission / intermissions. The study examined the personality characteristics of endogenous psychoses with an episodic course in remission / intermission conditions and established signs and nosospecific differences in post-manifest pathological transformations in patients with schizophrenia, schizoaffective disorder, and affective disorders. Existing pathopersonalogical transformations are characterized by signs of multidirectional tendencies of compensatory tension of personal resources, which is confirmed by the presence of several moderately elevated (65-75 T-points) indicators of individual scales and a simultaneous increase in indicators of both hyposthenic (2nd and 7th scales) and hypersthenic ( 4th and 9th scales) registers. In schizoaffective disorder, such scales are the 2nd (65.36±12.28 T-points), 4th (73.23±11.83 T-points), 8th (68.40±12.33 T-points) and 9th (66.05±12.02 T-points); in affective disorders, these are the 2nd, 4th and 8th scales (67.72±13.96, 67.08±9.53 and 65.90±10.08 T-points, respectively); for schizophrenia, such scales are the 2nd (72.37 ± 16.80 T-points), 4th (69.47±12.48 T-points), 7th (66.59±15.69 T-points) ) and 8th (71.73±19.95 T-points). The obtained data can be used as a component of the differential diagnosis system and personified psychotherapeutic support.


1937 ◽  
Vol 33 (3) ◽  
pp. 299-305
Author(s):  
D. V. Afanasiev

As you know, most mental illnesses are based on poisoning of the body, in particular the nervous system, poisonous substances or toxins that can come from the outside (exogenous diseases) or can form inside the body (autointoxication, endogenous diseases). If we could in some way stop the process of intoxication or at least reduce it, then we could achieve weakening or even cessation of exogenous or endogenous mental illness. If in exogenous intoxication psychoses the poison enters the body from the outside and may be more or less known to us (alcohol, drugs, etc.), then in endogenous psychoses (schizophrenia, epilepsy, etc.), the composition of toxins is unknown to us.


2020 ◽  
Vol 31 ◽  
pp. S69-S70
Author(s):  
G. Mamedova ◽  
N. Zakharova ◽  
V. Ushakov ◽  
S. Kartashov ◽  
R. Binyakovskiy

1989 ◽  
Vol 29 (3) ◽  
pp. 331-333 ◽  
Author(s):  
J. Schroeder ◽  
H. Sauer ◽  
K.-R. Wilhelm ◽  
T. Niedermeier ◽  
P. Georgi

Author(s):  
MIRCEA LAZARESCU ◽  
MONICA IENCIU
Keyword(s):  

1997 ◽  
Vol 28 (2-3) ◽  
pp. 257-265 ◽  
Author(s):  
Jorge Ciprian-Ollivier ◽  
Marcelo G. Cetkovich-Bakmas

2017 ◽  
Vol 162 (4) ◽  
pp. 425-429 ◽  
Author(s):  
A. S. Tomyshev ◽  
I. S. Lebedeva ◽  
T. A. Akhadov ◽  
M. A. Omel’chenko ◽  
M. V. Ublinskii ◽  
...  

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