Beneficial Effects of Stress Response Blockade on Patients Undergoing Surgery

Adaptative response to stress is a strategy conserved across evolution to promote survival. In this context, the groundbreaking findings of Miroslav Radman on the adaptative value of changing mutation rates opened new avenues in our understanding of stress response. Inspired by this work, we explore here the putative beneficial effects of changing the ends of eukaryotic chromosomes, the telomeres, in response to stress. We first summarize basic principles in telomere biology and then describe how various types of stress can alter telomere structure and functions. Finally, we discuss the hypothesis of stress-induced telomere signaling with hormetic effects.

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Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety

10.21203/rs.3.rs-823079/v1 ◽

2021 ◽

Author(s):

Malalaniaina Rakotobe ◽

Niels Fjerdingstad ◽

Nuria Ruiz-Reig ◽

Thomas Lamonerie ◽

Fabien D'Autréaux

Keyword(s):

Stress Response ◽

Brain Development ◽

Chronic Stress ◽

Environmental Stressors ◽

Critical Node ◽

Sensitive Periods ◽

Early Stress ◽

Effects Of Stress

Abstract Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these differences are unknown. Key answers may lie in how genetic and environmental stressors interact to shape the circuits controlling emotions. Here we studied the role of the habenulo-interpeducuncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety. We found that a subcircuit of this system, characterized by Otx2 expression, is particularly responsive to chronic stress during puberty, which induces HIPS hypersensitivity to later stress and susceptibility to develop anxiety. We further show that Otx2 deletion restricted to the HIPS counteracts these effects of stress. Together, these results demonstrate that Otx2 and stress interact, around puberty, to shape the HIPS stress-response, revealed here as a key modulator of susceptibility/resilience to develop anxiety.

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Using Research in Practice: Some Beneficial Effects of Stress

Western Journal of Nursing Research ◽

10.1177/019394598300500113 ◽

1983 ◽

Vol 5 (1) ◽

pp. 99-104

Author(s):

Barbara F. Fuller

Keyword(s):

Beneficial Effects ◽

Effects Of Stress

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Beneficial effects of thyme (Thymus vulgaris ) extract on oxytetracycline-induced stress response, immunosuppression, oxidative stress and enzymatic changes in rainbow trout (Oncorhynchus mykiss )

Aquaculture Nutrition ◽

10.1111/anu.12853 ◽

2018 ◽

Vol 25 (2) ◽

pp. 298-309 ◽

Cited By ~ 23

Author(s):

Seyyed Morteza Hoseini ◽

Morteza Yousefi

Keyword(s):

Oxidative Stress ◽

Rainbow Trout ◽

Stress Response ◽

Oncorhynchus Mykiss ◽

Thymus Vulgaris ◽

Beneficial Effects ◽

Rainbow Trout Oncorhynchus Mykiss ◽

Induced Stress ◽

Enzymatic Changes

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Exploring the Bile Stress Response of Lactobacillus mucosae LM1 through Exoproteome Analysis

Molecules ◽

10.3390/molecules26185695 ◽

2021 ◽

Vol 26 (18) ◽

pp. 5695

Author(s):

Bernadette B. Bagon ◽

Ju Kyoung Oh ◽

Valerie Diane V. Valeriano ◽

Edward Alain B. Pajarillo ◽

Dae-Kyung Kang

Keyword(s):

Stress Response ◽

Ribosomal Proteins ◽

High Performance ◽

Phosphoglycerate Kinase ◽

Label Free ◽

Beneficial Effects ◽

Extracellular Proteome ◽

Liquid Chromatography Tandem Mass ◽

Lactobacillus Mucosae

Lactobacillus sp. have long been studied for their great potential in probiotic applications. Recently, proteomics analysis has become a useful tool for studies on potential lactobacilli probiotics. Specifically, proteomics has helped determine and describe the physiological changes that lactic acid bacteria undergo in specific conditions, especially in the host gut. In particular, the extracellular proteome, or exoproteome, of lactobacilli contains proteins specific to host– or environment–microbe interactions. Using gel-free, label-free ultra-high performance liquid chromatography tandem mass spectrometry, we explored the exoproteome of the probiotic candidate Lactobacillus mucosae LM1 subjected to bile treatment, to determine the proteins it may use against bile stress in the gut. Bile stress increased the size of the LM1 exoproteome, secreting ribosomal proteins (50S ribosomal protein L27 and L16) and metabolic proteins (lactate dehydrogenase, phosphoglycerate kinase, glyceraldehyde-3-phosphate dehydrogenase and pyruvate dehydrogenases, among others) that might have moonlighting functions in the LM1 bile stress response. Interestingly, membrane-associated proteins (transporters, peptidase, ligase and cell division protein ftsH) were among the key proteins whose secretion were induced by the LM1 bile stress response. These specific proteins from LM1 exoproteome will be useful in observing the proposed bile response mechanisms via in vitro experiments. Our data also reveal the possible beneficial effects of LM1 to the host gut.

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Stress and Skin: An Overview of Mind Body Therapies as a Treatment Strategy in Dermatology

Dermatology Practical & Conceptual ◽

10.5826/dpc.1104a91 ◽

2021 ◽

pp. e2021091

Author(s):

Rachel Graubard ◽

Ariadna Perez-Sanchez ◽

Rajani Katta

Keyword(s):

Stress Response ◽

Skin Disease ◽

Skin Barrier ◽

Psychosocial Outcomes ◽

Skin Inflammation ◽

The Body ◽

Skin Barrier Function ◽

Beneficial Effects ◽

Potential Benefits ◽

The Mind

Stress has multiple and wide-ranging physiologic and clinical impacts on skin disease. This has led to an interest in mind body therapies as potential adjunct treatments for skin disease. The stress response results in the activation of the endocrine, neurologic, and immune systems, with a resulting cascade of impacts, that are both systemic and cutaneous. The 2 main arms of the stress response are the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis. The resultant release of cortisol, catecholamines, and neuropeptides has multiple effects. Clinically, these have been shown to increase skin inflammation, increase itching, impair skin barrier function, impair wound healing, and suppress immunity.Mind body therapies are those that focus on the interaction between the mind and the body, with the goal to influence physical function and impact health. These have been shown to ameliorate some of the harmful physiologic changes attributed to stress or to reduce harmful behaviors. In some cases, such as with biofeedback, they may also result in beneficial physiologic changes. Treatments such as meditation, biofeedback, hypnosis, guided imagery, and others have been evaluated in the treatment of skin disease and have shown some benefits. Although randomized controlled trials are limited, these interventions have shown beneficial effects on itching, psychosocial outcomes, and even skin severity. These interventions have been evaluated in diseases such as atopic dermatitis, psoriasis, trichotillomania, and others. Given the potential benefits, improvements in psychosocial outcomes, and a low risk profile, referral to qualified practitioners or multidisciplinary clinics should be considered for some patients.

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Alanyl-tRNA Synthetase Quality Control Prevents Global Dysregulation of the Escherichia coli Proteome

mBio ◽

10.1128/mbio.02921-19 ◽

2019 ◽

Vol 10 (6) ◽

Cited By ~ 1

Author(s):

Paul Kelly ◽

Nicholas Backes ◽

Kyle Mohler ◽

Christopher Buser ◽

Arundhati Kavoor ◽

...

Keyword(s):

Escherichia Coli ◽

Protein Synthesis ◽

Stress Response ◽

Genetic Material ◽

Trna Synthetase ◽

Content Type ◽

Beneficial Effects ◽

Protein Mass ◽

Protein Mass Spectrometry

ABSTRACT Mechanisms have evolved to prevent errors in replication, transcription, and translation of genetic material, with translational errors occurring most frequently. Errors in protein synthesis can occur at two steps, during tRNA aminoacylation and ribosome decoding. Recent advances in protein mass spectrometry have indicated that previous reports of translational errors have potentially underestimated the frequency of these events, but also that the majority of translational errors occur during ribosomal decoding, suggesting that aminoacylation errors are evolutionarily less tolerated. Despite that interpretation, there is evidence that some aminoacylation errors may be regulated, and thus provide a benefit to the cell, while others are clearly detrimental. Here, we show that while it has been suggested that regulated Thr-to-Ser substitutions may be beneficial, there is a threshold beyond which these errors are detrimental. In contrast, we show that errors mediated by alanyl-tRNA synthetase (AlaRS) are not well tolerated and induce a global stress response that leads to gross perturbation of the Escherichia coli proteome, with potentially catastrophic effects on fitness and viability. Tolerance for Ala mistranslation appears to be much lower than with other translational errors, consistent with previous reports of multiple proofreading mechanisms targeting mischarged tRNAAla. These results demonstrate the essential role of aminoacyl-tRNA proofreading in optimizing cellular fitness and suggest that any potentially beneficial effects of mistranslation may be confined to specific amino acid substitutions. IMPORTANCE Errors in protein synthesis have historically been assumed to be detrimental to the cell. While there are many reports that translational errors are consequential, there is a growing body of evidence that some mistranslation events may be tolerated or even beneficial. Using two models of mistranslation, we compare the direct phenotypic effects of these events in Escherichia coli. This work provides insight into the threshold for tolerance of specific mistranslation events that were previously predicted to be broadly neutral to proteome integrity. Furthermore, these data reveal the effects of mistranslation beyond the general unfolded stress response, leading to global translational reprogramming.

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Role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to stressinduced anxiety

10.21203/rs.3.rs-823079/v2 ◽

2022 ◽

Author(s):

Malalaniaina Rakotobe ◽

Niels Fjerdingstad ◽

Nuria Ruiz-Reig ◽

Thomas Lamonerie ◽

Fabien D'Autréaux

Keyword(s):

Stress Response ◽

Brain Development ◽

Chronic Stress ◽

Environmental Stressors ◽

Critical Node ◽

Sensitive Periods ◽

Early Stress ◽

Effects Of Stress

Abstract Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these differences are unknown. Key answers may lie in how genetic and environmental stressors interact to shape the circuits controlling emotions. Here we studied the role of the habenulo-interpeducuncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety. We found that a subcircuit of this system, characterized by Otx2 expression, is particularly responsive to chronic stress during puberty, which induces HIPS hypersensitivity to later stress and susceptibility to develop anxiety. We further show that Otx2 deletion restricted to the HIPS counteracts these effects of stress. Together, these results demonstrate that Otx2 and stress interact, around puberty, to shape the HIPS stress-response, revealed here as a key modulator of susceptibility/resilience to develop anxiety.

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Role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to stress-induced anxiety

10.21203/rs.3.rs-823079/v3 ◽

2022 ◽

Author(s):

Malalaniaina Rakotobe ◽

Niels Fjerdingstad ◽

Nuria Ruiz-Reig ◽

Thomas Lamonerie ◽

Fabien D'Autréaux

Keyword(s):

Stress Response ◽

Brain Development ◽

Chronic Stress ◽

Environmental Stressors ◽

Critical Node ◽

Sensitive Periods ◽

Early Stress ◽

Effects Of Stress

Abstract Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these differences are unknown. Key answers may lie in how genetic and environmental stressors interact to shape the circuits controlling emotions. Here we studied the role of the habenulo-interpeducuncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety. We found that a subcircuit of this system, characterized by Otx2 expression, is particularly responsive to chronic stress during puberty, which induces HIPS hypersensitivity to later stress and susceptibility to develop anxiety. We further show that Otx2 deletion restricted to the HIPS counteracts these effects of stress. Together, these results demonstrate that Otx2 and stress interact, around puberty, to shape the HIPS stress-response, revealed here as a key modulator of susceptibility/resilience to develop anxiety.

Download Full-text