Cartilaginous Tumors and Cartilage-Forming Tumor-like Conditions of the Bones and Soft Tissues

Author(s):  
Frieda Feldman
2019 ◽  
Vol 7 (3) ◽  
pp. e000808
Author(s):  
Michael Joseph De Cozar ◽  
Elizabeth Barr

A 12-year-old Irish sports horse gelding presented with a recently developed oval firm mass at the plantaromedial aspect of right tarsus, located between the gastrocnemius and deep digital flexor tendon. At presentation, the horse was mildly right hind lame, with no exacerbation with flexion. Radiography and ultrasonography revealed an ovoid mineralised mass within soft tissues plantaromedially to tarsus and distal tibia and not associated with tarsal sheath or calcaneal bursa. Due to mild intermittent lameness and concerns regarding possibility for further increase in size, the horse underwent en bloc removal of the calcified mass under general anaesthesia. Histopathology showed the mass contained fibrous reactive connective tissue, undergoing bone and cartilage metaplasia and degeneration, with a central area of calcified bone and surrounding region of mononuclear inflammation. These characteristics although reminiscent of calcinosis circumscripta were diagnosed as focal dystrophic calcification. The horse made a full recovery and returned to a normal exercise level.


Author(s):  
Navneet Sharma ◽  
Shalender Kumar

The tripod of life comprises of three vital organs namely brain, heart and lungs. Serious pathological and morphological abnormalities of any part of the body prove fatal due to direct or indirect involvement of either or all of the organs of tripod of life. Essential structures of neck including nerves, blood vessels, and other have a direct or indirect control on the function of respiratory, circulatory and nervous system. The compression of the neck involving the important structures may prove fatal. One of the major modes of death is asphyxia and type of asphyxia most commonly encountered in medico legal practice is mechanical asphyxia. Among the means of producing mechanical asphyxia, constriction around the neck plays a major role. Backgroubd: Hanging is one of the most common methods of suicide in India; other types of hangings are homicidal hanging, judicial hanging, and autoerotic hanging (camps et al, 1976)3. Hanging differs from strangulation in which the neck is constricted irrespective of any effect caused by the weight of the body. The various structures damaged in hanging and strangulation include the soft tissues like skin, subcutaneous tissue, fascia, muscles, blood vessels, lymph nodes and the bony and cartilage tissues like the hyoid bone and larynx  (A. Keithmant, 1984)1. Various forms of strangulations are ligature strangulation, throttling, mugging, garrotting, bansdola etc (Simpson and knight, 1988)13. As till now very less studies has been carried out in western Rajasthan on demographic pattern of deaths due to compression of neck by ligature matterial. A study of asphyxial  deaths by ligature matterial that is hanging and ligature strangulation in relation of sex, age, region and religion  has been undertaken.  Keywords: Hanging, Strangulation, Ligature, Neck, Demographic, Medico-Legal.


1996 ◽  
Vol 17 (7) ◽  
pp. 413-416 ◽  
Author(s):  
Ciro Villani ◽  
Gabriele Tucci ◽  
Mariantonietta Di Mille ◽  
Stefano Di Gennaro ◽  
Alessandro Corsi

A large soft tissue mass of the left ankle was documented by ultrasonography in a 24-year-old man. Histologic examination of biopsy samples was consistent with pigmented villonodular synovitis. Magnetic resonance, performed to establish the extension of the mass, revealed an extra-articular lesion involving the posteromedial extra-articular soft tissues, which, by means of a thin peduncle, extended into the subtalar joint space. The mass was excised; gross and microscopic examinations were characteristic of localized nodular synovitis. Bone and cartilage abnormalities were not revealed by either preoperative imaging or surgery. At 15-month follow-up, the patient was free of recurrences. This case is an uncommon example of localized nodular synovitis of the subtalar joint, characterized by the absence of bone and articular cartilage abnormalities. In addition, this case reveals that the pattern of growth (i.e., the shape of the lesion) is an important factor in determining secondary lesions of bone and cartilage.


2021 ◽  
Vol 9 (6) ◽  
pp. 232596712110104
Author(s):  
Seong Hwan Kim ◽  
Yong-Beom Park ◽  
Boo-Seop Kim ◽  
Dong-Hoon Lee ◽  
Nicolas Pujol

Background: The incidence of concomitant injuries, including meniscal and cartilage injuries, has not been adequately reported in previous studies on multiligament knee injury (MLKI) because their primary focal points have been the degree of ligament injury, treatment strategy, involvement of other soft tissues, and neurovascular injury. Purpose: To analyze the incidence of associated lesions in MLKIs, including medial and lateral meniscal injuries, cartilage lesions, and complications. Study Design: Systemic review; Level of evidence, 4. Methods: The PubMed, Embase, Cochrane Library, CINAHL, and Scopus databases were searched between inception and April 30, 2020. Studies were included if they reported the incidence rates of medial and/or lateral meniscal tears and cartilage injuries in cases of MLKIs. For the meta-analysis, data were extracted on clinical outcomes measured according to the number of medial and/or lateral meniscal tears, cartilage injuries, and complications. Results: A total of 45 studies were included in the MLKI analysis (3391 patients). The pooled rate of medial meniscal tears was 30.4% (95% CI, 24.1%-37.1%; P < .0001; I 2 = 85.8%). The pooled rate of lateral meniscal tears was 27.5% (95% CI, 20.3%-35.3%; P < .0001; I 2 = 89.6%). The pooled rate of cartilage injuries was 27.5% (95% CI, 22.1%-33.3%; P < .0001; I 2 = 86.8%). The pooled rates of peroneal nerve injuries, vascular injuries, and arthrofibrosis were 19.2% (95% CI, 14.2%-24.7%; P < .001; I 2 = 81.3%), 18.4% (95% CI, 13.2%-24.3%; P < .0001; I 2 = 81.0%), and 11.2% (95% CI, 8.1%-14.7%; P = .0018; I 2 = 54.0%), respectively. Conclusion: The pooled rates of meniscal tears and cartilage injuries concomitant with MLKIs were high, ranging from 27% to 30%, and the pooled rates of peroneal nerve injury, vascular injury, and arthrofibrosis were considerable, ranging from 11% to 19%. The influence of these associated lesions on clinical results should be evaluated in future clinical studies.


Author(s):  
C.A. Baechler ◽  
W. C. Pitchford ◽  
J. M. Riddle ◽  
C.B. Boyd ◽  
H. Kanagawa ◽  
...  

Preservation of the topographic ultrastructure of soft biological tissues for examination by scanning electron microscopy has been accomplished in the past by using lengthy epoxy infiltration techniques, or dehydration in ethanol or acetone followed by air drying. Since the former technique requires several days of preparation and the latter technique subjects the tissues to great stress during the phase change encountered during air-drying, an alternate rapid, economical, and reliable method of surface structure preservation was developed. Turnbill and Philpott had used a fluorocarbon for the critical point drying of soft tissues and indicated the advantages of working with fluids having both moderately low critical pressures as well as low critical temperatures. Freon-116 (duPont) which has a critical temperature of 19. 7 C and a critical pressure of 432 psi was used in this study.


Author(s):  
M.E. Lee ◽  
A. Moller ◽  
P.S.O. Fouche ◽  
I.G Gaigher

Scanning electron microscopy of fish scales has facilitated the application of micro-structures to systematics. Electron microscopy studies have added more information on the structure of the scale and the associated cells, many problems still remain unsolved, because of our incomplete knowledge of the process of calcification. One of the main purposes of these studies has been to study the histology, histochemistry, and ultrastructure of both calcified and decalcified scales, and associated cells, and to obtain more information on the mechanism of calcification in the scales. The study of a calcified scale with the electron microscope is complicated by the difficulty in sectioning this material because of the close association of very hard tissue with very soft tissues. Sections often shatter and blemishes are difficult to avoid. Therefore the aim of this study is firstly to develop techniques for the preparation of cross sections of fish scales for scanning electron microscopy and secondly the application of these techniques for the determination of the structures and calcification of fish scales.


Author(s):  
Yasushi P. Kato ◽  
Michael G. Dunn ◽  
Frederick H. Silver ◽  
Arthur J. Wasserman

Collagenous biomaterials have been used for growing cells in vitro as well as for augmentation and replacement of hard and soft tissues. The substratum used for culturing cells is implicated in the modulation of phenotypic cellular expression, cellular orientation and adhesion. Collagen may have a strong influence on these cellular parameters when used as a substrate in vitro. Clinically, collagen has many applications to wound healing including, skin and bone substitution, tendon, ligament, and nerve replacement. In this report we demonstrate two uses of collagen. First as a fiber to support fibroblast growth in vitro, and second as a demineralized bone/collagen sponge for radial bone defect repair in vivo.For the in vitro study, collagen fibers were prepared as described previously. Primary rat tendon fibroblasts (1° RTF) were isolated and cultured for 5 days on 1 X 15 mm sterile cover slips. Six to seven collagen fibers, were glued parallel to each other onto a circular cover slip (D=18mm) and the 1 X 15mm cover slip populated with 1° RTF was placed at the center perpendicular to the collagen fibers. Fibroblast migration from the 1 x 15mm cover slip onto and along the collagen fibers was measured daily using a phase contrast microscope (Olympus CK-2) with a calibrated eyepiece. Migratory rates for fibroblasts were determined from 36 fibers over 4 days.


2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.


1989 ◽  
Vol 16 (1) ◽  
pp. 177-186 ◽  
Author(s):  
Fernando Ortiz Monasterio ◽  
Ernesto J. Ruas

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