Mass screening and early detection

1982 ◽  
pp. 59-64
Author(s):  
2002 ◽  
Vol 32 (1-2) ◽  
pp. 6-14 ◽  
Author(s):  
J. C. Craig ◽  
A. Barratt ◽  
R. Cumming ◽  
L. Irwig ◽  
G. Salkeld

2012 ◽  
Vol 30 (30_suppl) ◽  
pp. 17-17
Author(s):  
Alejandro Corvalan ◽  
Maria Jose Maturana ◽  
Marianela Sanchez ◽  
Alfonso Calvo ◽  
Catterina Ferreccio

17 Background: Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. Previously, we identified a potential biomarker for non-invasive detection of GC, the DNA methylation of the promoter region of Reprimo, a p53-dependent G2 arrest mediator candidate (Clin Cancer Res 2008;14:6264-9). Furthermore, we developed a quantitative assay (MethyLight) for a mass screening of GC (DDW2011-1029128). Here we reported the preliminary findings of our ongoing prospective trial STEAD-GC (Screening and Triage test for Early Detection of Gastric Cancer) which is being conducted in Chile, a country with a high mortality rate for GC. Methods: Twenty GC cases (tumor, non-tumor tissues and plasma samples) and 41 symptomatic chronic gastritis cases (29 tissues and 12 pairs of tissue and plasma samples) were evaluated for Reprimo levels by MethyLight after DNA extraction and bisulfite conversion. Results: Concentrations of DNA were similar in both groups (Avg 32.2 ng/ml [range: 8.9-70.8 ng/ml]). The average DNA levels of Reprimo were higher in GC [964,215 copies/ml, 539,593 copies/ml and 80,113 copies/ml in tumor, non-tumor and plasma, respectively] but lower in symptomatic chronic gastritis [137,721 copies/ml and 8,387 copies/ml, tissue and plasma, respectively]. Methods: Twenty GC cases (tumor, non-tumor tissues, and plasma samples) and 41 symptomatic chronic gastritis cases (29 tissues and 12 pairs of tissue and plasma samples) were evaluated for Reprimo levels by MethyLight after DNA extraction and bisulfite conversion. Conclusions: By using our previous cut-off of 15,125 copies/ml, our method correctly identified 10 out of 12 gastritis cases and 16 out of 20 GC cases (p value <0.001). Our data confirms our non-invasive method for early detection of GC may be suitable for a mass screening of GC.


2020 ◽  
Vol 20 (2) ◽  
pp. 173
Author(s):  
Zaina Al-Dhahli ◽  
Salma M. Al-Sheibani ◽  
Faisal Al-Kalbani ◽  
Jamil Hyder

Objectives: The prognosis of head and neck cancer (HNC) depends substantially on disease stage at the time of diagnosis. Unfortunately, the majority of HNC patients present at relatively late stages. In Oman, a national screening campaign was conducted to increase public awareness of HNC and encourage early detection. This study aimed to report the outcomes of that campaign. Methods: The campaign took the form of biannual events conducted at a tertiary care centre and in public malls in Muscat, Oman from April 2015 to July 2019. Data were collected from participants using the Head and Neck Cancer Alliance screening form. Otolaryngologists and oral maxillofacial surgeons performed a thorough physical evaluation of the head and neck region. Results: Of the 1,500 individuals visiting the hospital and malls during the campaign events, a total of 509 agreed to undergo screening (response rate: 33.9%). Of these, 12.8% had positive screening results and 5.9% required further evaluation. However, none of the cases with suspicious findings were found to be malignant after a thorough evaluation. Overall, 16.9% of the participants were aware of the early signs of HNC; in addition, 5.5% knew how to perform an oral self-examination. Conclusion: Screening is a simple and safe method for the prevention and early detection of HNC. Mass screening and public awareness programmes may help to reduce the burden of this disease in Oman.Keywords: Head and Neck Cancer; Early Detection of Cancer; Mass Screening; Knowledge; Health Risk Behaviors; Oman.


2003 ◽  
Vol 45 (2) ◽  
pp. 142-149 ◽  
Author(s):  
Junko Yoshida ◽  
Masami Tsuchiya ◽  
Noriko Tatsuma ◽  
Mutsumi Murakami

1988 ◽  
Vol 77 (11) ◽  
pp. 1671-1674 ◽  
Author(s):  
Yutaka YOSHIDA

Author(s):  
Michio Kimura ◽  
Kohichi Yoshida ◽  
Akio Ohuchi ◽  
Noriaki Ohuchi ◽  
Ken-ichi Shiiba ◽  
...  

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