Design and Performance of a Pilot Scale High-Gradient Magnetic Filter Using a Mandhala Magnet and Its Application for Soy–Whey Protein Purification

Abstract Background Large (48-g), isonitrogenous doses of rice and whey protein have previously been shown to stimulate similar adaptations to resistance training, but the impact of consuming smaller doses has yet to be compared. We evaluated the ability of 24-g doses of rice or whey protein concentrate to augment adaptations following 8 weeks of resistance training. Methods Healthy resistance-trained males (n = 24, 32.8 ± 6.7 years, 179.3 ± 8.5 cm, 87.4 ± 8.5 kg, 27.2 ± 1.9 kg/m2, 27.8 ± 6.0% fat) were randomly assigned and matched according to fat-free mass to consume 24-g doses of rice (n = 12, Growing Naturals, LLC) or whey (n = 12, NutraBio Labs, Inc.) protein concentrate for 8 weeks while completing a standardized resistance training program. Body composition (DXA), muscular strength (one-repetition maximum [1RM]) and endurance (repetitions to fatigue [RTF] at 80% 1RM) using bench press (BP) and leg press (LP) exercises along with anaerobic capacity (Wingate) were assessed before and after the intervention. Subjects were asked to maintain regular dietary habits and record dietary intake every 2 weeks. Outcomes were assessed using 2 × 2 mixed (group x time) factorial ANOVA with repeated measures on time and independent samples t-tests using the change scores from baseline. A p-value of 0.05 and 95% confidence intervals on the changes between groups were used to determine outcomes. Results No baseline differences (p > 0.05) were found for key body composition and performance outcomes. No changes (p > 0.05) in dietary status occurred within or between groups (34 ± 4 kcal/kg/day, 3.7 ± 0.77 g/kg/day, 1.31 ± 0.28 g/kg/day, 1.87 ± 0.23 g/kg/day) throughout the study for daily relative energy (34 ± 4 kcals/kg/day), carbohydrate (3.7 ± 0.77 g/kg/day), fat (1.31 ± 0.28 g/kg/day), and protein (1.87 ± 0.23 g/kg/day) intake. Significant main effects for time were revealed for body mass (p = 0.02), total body water (p = 0.01), lean mass (p = 0.008), fat-free mass (p = 0.007), BP 1RM (p = 0.02), BP volume (p = 0.04), and LP 1RM (p = 0.01). Changes between groups were similar for body mass (− 0.88, 2.03 kg, p = 0.42), fat-free mass (− 0.68, 1.99 kg, p = 0.32), lean mass (− 0.73, 1.91 kg, p = 0.37), fat mass (− 0.48, 1.02 kg, p = 0.46), and % fat (− 0.63, 0.71%, p = 0.90). No significant between group differences were seen for BP 1RM (− 13.8, 7.1 kg, p = 0.51), LP 1RM (− 38.8, 49.6 kg, p = 0.80), BP RTF (− 2.02, 0.35 reps, p = 0.16), LP RTF (− 1.7, 3.3 reps, p = 0.50), and Wingate peak power (− 72.5, 53.4 watts, p = 0.76) following the eight-week supplementation period. Conclusions Eight weeks of daily isonitrogenous 24-g doses of rice or whey protein in combination with an eight-week resistance training program led to similar changes in body composition and performance outcomes. Retroactively registered on as NCT04411173.

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Sustaining open innovation through a “Center of Excellence”

Strategy and Leadership ◽

10.1108/sl-02-2019-0031 ◽

2019 ◽

Vol 47 (3) ◽

pp. 19-26 ◽

Cited By ~ 1

Author(s):

Elizabeth E. Richard ◽

Jeffrey R. Davis ◽

Jin H. Paik ◽

Karim R. Lakhani

Keyword(s):

Open Innovation ◽

Business Strategy ◽

Pilot Scale ◽

Lessons Learned ◽

Cultural Issues ◽

Content Type ◽

Center Of Excellence ◽

And Performance ◽

Time Required ◽

The Right

Purpose This paper presents NASA’s experience using a Center of Excellence (CoE) to scale and sustain an open innovation program as an effective problem-solving tool and includes strategic management recommendations for other organizations based on lessons learned. Design/methodology/approach This paper defines four phases of implementing an open innovation program: Learn, Pilot, Scale and Sustain. It provides guidance on the time required for each phase and recommendations for how to utilize a CoE to succeed. Recommendations are based upon the experience of NASA’s Human Health and Performance Directorate, and experience at the Laboratory for Innovation Science at Harvard running hundreds of challenges with research and development organizations. Findings Lessons learned include the importance of grounding innovation initiatives in the business strategy, assessing the portfolio of work to select problems most amenable to solving via crowdsourcing methodology, framing problems that external parties can solve, thinking strategically about early wins, selecting the right platforms, developing criteria for evaluation, and advancing a culture of innovation. Establishing a CoE provides an effective infrastructure to address both technical and cultural issues. Originality/value The NASA experience spanned more than seven years from initial learnings about open innovation concepts to the successful scaling and sustaining of an open innovation program; this paper provides recommendations on how to decrease this timeline to three years.

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Enzyme inactivation and drying technologies influencing the vasorelaxant activity of a whey protein hydrolysate in semi-pilot scale

International Dairy Journal ◽

10.1016/j.idairyj.2019.01.016 ◽

2019 ◽

Vol 93 ◽

pp. 11-14 ◽

Cited By ~ 3

Author(s):

Luísa Ozorio ◽

Nariana R. Pereira ◽

José E. da Silva-Santos ◽

Ana I.S. Brígida ◽

Caroline Mellinger-Silva ◽

...

Keyword(s):

Whey Protein ◽

Protein Hydrolysate ◽

Pilot Scale ◽

Enzyme Inactivation ◽

Vasorelaxant Activity ◽

Whey Protein Hydrolysate

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Pilot Plant Studies on Filtration of Raw Sewage Using Floating Filter Media and Multiple Filter Column Inlets

Water Science & Technology ◽

10.2166/wst.1993.0155 ◽

1993 ◽

Vol 28 (7) ◽

pp. 143-151 ◽

Cited By ~ 6

Author(s):

Mitsuo Mouri ◽

Chiaki Niwa

Keyword(s):

Filtration Rate ◽

Pilot Scale ◽

Primary Treatment ◽

Medium Size ◽

Filter Surface ◽

And Performance ◽

Run Lengths ◽

Solid Liquid ◽

Solid Liquid Separation ◽

Soluble Components

The characteristics and performance of solid-liquid separation of raw sewage using floating media and multiple inlets were studied using pilot-scale equipment. Particles over 7 µm, representing approximately 80% of SS and 50% of BOD in raw sewage were efficiently removed. Smaller particles and soluble components, comprising a large part of total BOD, were difficult to remove by filtration. The maximum SS removal ratio (SSRR) and SS quantity removed per unit filter surface (SSR) was achieved using a medium size of 5.5 mm and a filtration rate of 150 µm/d. Inlet switching to a lower position significantly extended the filter run lengths and increased the total SS removed by filtration. Using 5.5 mm filter particles and a 150 m/d filtration rate, 80-89% of SS was removed, 38-42 kg of SS was removed per unit filter sectional area, and filter runs were 55-65 hours. The backwash-filtrate ratio was around 2%. The space requirement of this system will be significantly smaller than the ordinary primary treatment system judging from the trial design of a prototype plant.

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