Treatment of Post-hemorrhagic Cerebral Vasospasm: Role of Endovascular Therapy

2011 ◽  
pp. 127-132 ◽  
Author(s):  
Andrew Grande ◽  
Christopher Nichols ◽  
Usman Khan ◽  
Gail Pyne-Geithman ◽  
Todd Abruzzo ◽  
...  
Keyword(s):  
Cerebral Vasospasm ◽  
Endovascular Therapy

Endovascular Management of Cerebral Vasospasm

Neurosurgery ◽  
2006 ◽  
Vol 59 (suppl_5) ◽  
pp. S3-139-S3-147 ◽  
Author(s):  
Marike Zwienenberg-Lee ◽  
Jonathan Hartman ◽  
Nancy Rudisill ◽  
Jan Paul Muizelaar
Keyword(s):  
Clinical Significance ◽  
Cerebral Vasospasm ◽  
Endovascular Therapy ◽  
Balloon Angioplasty ◽  
Cerebral Aneurysms ◽  
Endovascular Management ◽  
Endovascular Techniques ◽  
Arterial Infusion ◽  
The Past

Abstract CEREBRAL VASOSPASM REMAINS a leading cause of death and disability in patients with ruptured cerebral aneurysms. The development of endovascular intervention in the past two decades has shown promising results in the treatment of vasospasm. Endovascular techniques that have been used in humans include intra-arterial infusion of vasorelaxants and direct mechanical dilation with transluminal balloon angioplasty. This article reviews the current indications and role of endovascular therapy in the management of cerebral vasospasm, its clinical significance, and potential future therapies.

scholarly journals Spontaneous Middle Cerebral Artery (MCA) dissection and stenosis: Role of vessel wall imaging and 3D-RA endoluminal view as adjunct diagnostic tools in endovascular therapy

2021 ◽  
Vol 25 ◽  
pp. 101170
Author(s):  
Mohd Fandi Al Khafiz Kamis ◽  
Mohd Naim Mohd Yaakob ◽  
Ezamin Abdul Rahim ◽  
Ahmad Sobri Muda ◽  
Mohamad Syafeeq Faeez Md Noh
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Endovascular Therapy ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Diagnostic Tools ◽  
Wall Imaging

The role of elevated levels of microRNA-155-5p and microRNA-124-5p in hyperuricemia and acute ischemic stroke

2021 ◽  
Vol 11 (10) ◽  
pp. 1674-1680
Author(s):  
Yuan Yao ◽  
Jun Yuan ◽  
Yanju Ma ◽  
Runxiu Zhu ◽  
Yong Ma
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Application ◽  
Cerebral Vasospasm ◽  
Rat Model ◽  
Inner Mongolia ◽  
Neuronal Apoptosis ◽  
Projection Neuron ◽  
Neuron Differentiation

Hyperuricemia is closely related to acute ischemic stroke (AIS). In our study, we investigated the pattern of miRNA-155-5p and miRNA-124-5p expressions along with its clinical application in AIS and hyperuricemia patients and in a hyperuricemia rat model by RT-qPCR. The hyperuricemia rat model was established, and we found that the levels of miRNA-155-5p and miRNA-124-5p were increased in the serum, brain and kidney tissues compared with those in the normal rats. We proved that the levels of miRNA-155-5p and miRNA-124-5p were also elevated in AIS, hyperuricemia and AIS accompanied with hyperuricemia patients enrolled from the department of neurology in Inner Mongolia People’s Hospital (IMPH). The miRNA-155-5p and miRNA-124-5p were mainly associated with neuronal apoptosis, cerebral vasospasm, neuron projection, neuron projection morphogenesis, neuron differentiation and exocytosis. The above results might provide clues for the study the pathogenesis of AIS and hyperuricemia.

scholarly journals Effects of cervical sympathectomy on vasospasm induced by meningeal haemorrhage in rabbits

2006 ◽  
Vol 64 (3a) ◽  
pp. 572-574 ◽  
Author(s):  
Antônio Tadeu de Souza Faleiros ◽  
Francisco Humberto de Abreu Maffei ◽  
Luiz Antonio de Lima Resende
Keyword(s):  
Cerebral Vasospasm ◽  
Basilar Artery ◽  
Sympathetic Ganglion ◽  
Cervical Sympathectomy

This study investigates the role of cervical sympathectomy in the prevention of acute vasospasm induced by meningeal haemorrhage in rabbits. Sixteen adult English Norfolk rabbits were divided into 2 experimental groups: bilateral cervical sympathectomy of the superior sympathetic ganglion (SSSG, n=8), and bilateral SSSG and sympathectomy of the inferior sympathetic ganglion (SISG, n=8). Other 24 animals were used as controls. Basilar artery diameter was evaluated by angiography. SSSG protected the animals against developing cerebral vasospasm; SSSG associated with SISG did not increase this effect.

scholarly journals Haemodynamic and anaesthetic management of patients undergoing endovascular therapy for cerebral vasospasm

2014 ◽  
Vol 01 (03) ◽  
pp. 204-209
Author(s):  
Audrey Tan ◽  
Suresh Tharmaradinam ◽  
Ramamani Mariappan ◽  
Pirjo Manninen ◽  
Lakshmi Venkatraghavan
Keyword(s):  
Blood Pressure ◽  
Endovascular Treatment ◽  
Cerebral Vasospasm ◽  
Endovascular Therapy ◽  
Anaesthetic Management ◽  
Rehabilitation Centre ◽  
Endovascular Interventions ◽  
Anaesthetic Care ◽  
Hospital To Home ◽  
Hypertensive Therapy

Abstract Background: Cerebral vasospasm is a common and devastating complication after a subarachnoid haemorrhage (SAH). Current guidelines for treatment recommend hypertension with euvolaemia. Endovascular therapy with cerebral angioplasty and possible administration of intra-arterial vasodilators is indicated in patients who fail medical treatment. The objective of our study was to review the haemodynamic management and anaesthetic care of patients undergoing endovascular therapy for cerebral vasospasm in our institution. Materials and Methods: The medical records of all patients who underwent endovascular therapy for cerebral vasospasm between, April 2006 and September 2012, were reviewed retrospectively. Patients with clinical vasospasm were treated initially by inducing hypertension to systolic pressures of 140 to 170 mmHg; Endovascular treatment was performed, if there was no clinical improvement. Data was collected on blood pressure measurements, anaesthetic management, duration and complications of hypertensive therapy and outcome. The differences in the pre- and post-angioplasty systolic blood pressure were statistically analysed. Results: A total of 45 patients had 47 endovascular interventions, with balloon angioplasty for proximal vessel spasm and 16 (34%) patients had additional intra-arterial injection of a vasodilator agent. Onset of vasospasm was 7 days (range 2-15 days) after SAH. Vasospasm was usually seen in multiple vessels in the same patient regardless of the site of ruptured aneurysm and was present unilaterally in 80% of the patients. All patients had a general anaesthesia for the procedure. Prior to endovascular treatment 68.9% patients required vasopressors, but post angioplasty 93.3% required them. Norepinephrine was the most commonly used (66.2%). Angioplasty was successful in reversing the cerebral vasospasm as assessed by angiography in all patients with no intra-procedure complications. Overall 80% of patients were discharged from hospital to home or to a rehabilitation centre. Conclusion: Cerebral vasospasm affects multiple vessels in the same patient. Despite endovascular therapy being a successful intervention for proximal vessel spasm, most patients still required induced hypertension with even higher levels post angioplasty compared to pre angioplasty.

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