Transcriptional Control of Lymphatic Endothelial Cell Type Specification

2013 ◽  
pp. 5-22 ◽  
Author(s):  
Ying Yang ◽  
Guillermo Oliver
Keyword(s):  
Endothelial Cell ◽  
Transcriptional Control ◽  
Lymphatic Endothelial Cell ◽  
Cell Type ◽  
Type Specification ◽  
Endothelial Cell Type

scholarly journals Primary aortic intimal sarcoma of the endothelial cell type with long-term survival

1998 ◽  
Vol 27 (3) ◽  
pp. 555-558 ◽  
Author(s):  
James Majeski ◽  
E.Stanley Crawford ◽  
Elizabeth I. Majeski ◽  
John R. Duttenhaver
Keyword(s):  
Endothelial Cell ◽  
Cell Type ◽  
Term Survival ◽  
Long Term Survival ◽  
Intimal Sarcoma ◽  
Endothelial Cell Type

scholarly journals Establishment and Characterization of a Novel Gill Cell Line, LG-1, from Atlantic Lumpfish (Cyclopterus lumpus L.)

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2442
Author(s):  
Hilde Sindre ◽  
Mona C. Gjessing ◽  
Johanna Hol Fosse ◽  
Lene C. Hermansen ◽  
Inger Böckerman ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Cell Function ◽  
Fish Farming ◽  
Viral Hemorrhagic Septicemia Virus ◽  
Cell Type ◽  
Gill Cell ◽  
Cyclopterus Lumpus ◽  
Endothelial Cell Type

The use of lumpfish (Cyclopterus lumpus) as a cleaner fish to fight sea lice infestation in farmed Atlantic salmon has become increasingly common. Still, tools to increase our knowledge about lumpfish biology are lacking. Here, we successfully established and characterized the first Lumpfish Gill cell line (LG-1). LG-1 are adherent, homogenous and have a flat, stretched-out and almost transparent appearance. Transmission electron microscopy revealed cellular protrusions and desmosome-like structures that, together with their ability to generate a transcellular epithelial/endothelial resistance, suggest an epithelial or endothelial cell type. Furthermore, the cells exert Cytochrome P450 1A activity. LG-1 supported the propagation of several viruses that may lead to severe infectious diseases with high mortalities in fish farming, including viral hemorrhagic septicemia virus (VHSV) and infectious hematopoietic necrosis virus (IHNV). Altogether, our data indicate that the LG-1 cell line originates from an epithelial or endothelial cell type and will be a valuable in vitro research tool to study gill cell function as well as host-pathogen interactions in lumpfish.

Blood Platelet Plasminogen Activator Inhibitor: Two Different Pools of Endothelial Cell Type Plasminogen Activator Inhibitor in Human Blood

1986 ◽  
Vol 55 (03) ◽  
pp. 325-329 ◽  
Author(s):  
E D Sprengers ◽  
J W N Akkerman ◽  
B G Jansen
Keyword(s):  
Endothelial Cell ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Blood Platelet ◽  
Healthy Population ◽  
Cell Type ◽  
High Turnover ◽  
Type Plasminogen Activator ◽  
Activator Inhibitor ◽  
Endothelial Cell Type

SummaryAn assay for plasminogen activator inhibitor in human platelets is described. With this assay we find an average value of 6.8 × 10−8 IU/platelet (S.D. = 3.0 × 10−8; n = 20) in a healthy population. We characterized the PA-inhibitor from platelets and identified it as endothelial cell type plasminogen activator inhibitor, by its immunologic and functional properties. Besides the plasma pool of plasminogen activator inhibitor with a very high turnover rate, platelets constitute a second pool of plasminogen activator inhibitor in the circulation of the same order of magnitude. The two different pools of plasminogen activator inhibitor might have a different physiologic function.

A Sensitive Assay, Specific for Endothelial Cell Type Plasminogen Activator Inhibitor in Blood Plasma

1986 ◽  
Vol 55 (01) ◽  
pp. 074-077 ◽  
Author(s):  
E D Sprengers
Keyword(s):  
Endothelial Cell ◽  
Blood Plasma ◽  
Plasminogen Activator ◽  
Inhibitory Activity ◽  
Plasminogen Activator Inhibitor ◽  
Cell Type ◽  
Inhibitory Component ◽  
Type Plasminogen Activator ◽  
Endothelial Cell Type ◽  
In Blood Plasma

SummaryA polyclonal antibody raised against plasminogen activator (PA-)inhibitor from endothelial cells fully precipitates the PA-inhibitor in endothelial cell conditioned medium but only a part of the PA-inhibitory activity in blood plasma. This indicates that the PA-inhibitory activity in blood plasma is not due to a single inhibitory component. Performing the assay for PA-inhibitory activity in plasma both in the presence and absence of saturating concentrations of anti-endothelial cell PA-inhibitor antibodies, allows the determination of endothelial cell type PA-inhibitor in plasma. The assay gives a linear dose-response curve of amount of plasma added versus t-PA neutralised.Values for endothelial cell type PA-inhibitor in plasma of a group of 20 healthy individuals are in the range of 0.0-16.8 IU/ml and are not normally distributed (median value 3.0 IU/ml).This method also reveals a second, so far unidentified, PA-inhibitory component in human plasma.

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