Delayed Clot Removal and Experimental Vasospasm

2001 ◽  
pp. 33-35 ◽  
Author(s):  
Z.-D. Zhang ◽  
B. Yamini ◽  
T. Komuro ◽  
S. Ono ◽  
L. Johns ◽  
...  
Keyword(s):  
Clot Removal

scholarly journals Prehospital triage for endovascular clot removal in acute stroke patients

2016 ◽  
Vol 4 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Yu Suzuki ◽  
Yasuhiro Hasegawa ◽  
Kohtaro Tsumura ◽  
Toshihiro Ueda ◽  
Kazunari Suzuki ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Stroke Patients ◽  
Clot Removal ◽  
Prehospital Triage

Aggressive intraoperative cisternal clot removal after clipping aneurismal subarachnoid hemorrhage in elderly patients

2020 ◽  
Author(s):  
Tsutomu Yoshikane ◽  
Takeshi Miyazaki ◽  
Shinichi Yasuda ◽  
Masahiro Uchimura ◽  
Yuta Fujiwara ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Elderly Patients ◽  
Clot Removal

scholarly journals When the Blood Hits Your Brain: The Neurotoxicity of Extravasated Blood

2021 ◽  
Vol 22 (10) ◽  
pp. 5132
Author(s):  
Jesse A. Stokum ◽  
Gregory J. Cannarsa ◽  
Aaron P. Wessell ◽  
Phelan Shea ◽  
Nicole Wenger ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Surgical Intervention ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Critical Factor ◽  
Mass Effect ◽  
Direct Role ◽  
Scientific Curiosity ◽  
Clot Removal ◽  
Clinical Literature ◽  
The Central Nervous System

Hemorrhage in the central nervous system (CNS), including intracerebral hemorrhage (ICH), intraventricular hemorrhage (IVH), and aneurysmal subarachnoid hemorrhage (aSAH), remains highly morbid. Trials of medical management for these conditions over recent decades have been largely unsuccessful in improving outcome and reducing mortality. Beyond its role in creating mass effect, the presence of extravasated blood in patients with CNS hemorrhage is generally overlooked. Since trials of surgical intervention to remove CNS hemorrhage have been generally unsuccessful, the potent neurotoxicity of blood is generally viewed as a basic scientific curiosity rather than a clinically meaningful factor. In this review, we evaluate the direct role of blood as a neurotoxin and its subsequent clinical relevance. We first describe the molecular mechanisms of blood neurotoxicity. We then evaluate the clinical literature that directly relates to the evacuation of CNS hemorrhage. We posit that the efficacy of clot removal is a critical factor in outcome following surgical intervention. Future interventions for CNS hemorrhage should be guided by the principle that blood is exquisitely toxic to the brain.

scholarly journals Feasibility of Crosslinked Acrylic Shape Memory Polymer for a Thrombectomy Device

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Andrea D. Muschenborn ◽  
Keith Hearon ◽  
Brent L. Volk ◽  
Jordan W. Conway ◽  
Duncan J. Maitland
Keyword(s):  
Crosslink Density ◽  
Blood Clot ◽  
Shape Memory Polymer ◽  
Thermomechanical Properties ◽  
Recovery Stress ◽  
Element Analysis ◽  
Clot Removal ◽  
Acrylic Copolymers ◽  
Thrombectomy Device ◽  
And Performance

Purpose. To evaluate the feasibility of utilizing a system of SMP acrylates for a thrombectomy device by determining an optimal crosslink density that provides both adequate recovery stress for blood clot removal and sufficient strain capacity to enable catheter delivery. Methods. Four thermoset acrylic copolymers containing benzyl methacrylate (BzMA) and bisphenol A ethoxylate diacrylate (Mn∼512, BPA) were designed with differing thermomechanical properties. Finite element analysis (FEA) was performed to ensure that the materials were able to undergo the strains imposed by crimping, and fabricated devices were subjected to force-monitored crimping, constrained recovery, and bench-top thrombectomy. Results. Devices with 25 and 35 mole% BPA exhibited the highest recovery stress and the highest brittle response as they broke upon constrained recovery. On the contrary, the 15 mole% BPA devices endured all testing and their recovery stress (5 kPa) enabled successful bench-top thrombectomy in 2/3 times, compared to 0/3 for the devices with the lowest BPA content. Conclusion. While the 15 mole% BPA devices provided the best trade-off between device integrity and performance, other SMP systems that offer recovery stresses above 5 kPa without increasing brittleness to the point of causing device failure would be more suitable for this application.

Hybrid Magnetic Force and Torque Actuation of Miniature Helical Robots Using Mobile Coils to Accelerate Blood Clot Removal

2021 ◽  
Author(s):  
Lidong Yang ◽  
Moqiu Zhang ◽  
Haojin Yang ◽  
Zhengxin Yang ◽  
Li Zhang
Keyword(s):  
Magnetic Force ◽  
Blood Clot ◽  
Clot Removal

Endovascular

2016 ◽  
pp. 47-60
Author(s):  
Badih Daou ◽  
Pascal Jabbour
Keyword(s):  
Arteriovenous Malformations ◽  
Recombinant Tissue Plasminogen Activator ◽  
Primary Treatment ◽  
Therapeutic Window ◽  
Endovascular Management ◽  
Endovascular Interventions ◽  
Clot Removal ◽  
Endovascular Approach ◽  
Aneurysm Coiling

Endovascular neurosurgery has evolved dramatically since the first description of aneurysm coiling in 1991 and is now employed as a primary treatment strategy for managing a multitude of cerebrovascular pathologies, including aneurysms, arteriovenous malformations (AVMs), and acute ischemic stroke. The endovascular approach offers an attractive, minimally invasive alternative for aneurysm treatment with low procedure-related morbidity and mortality. The durability and long-term efficacy of endovascular interventions is continuously evolving, especially with the introduction of newer coils, stents, and flow-diversion techniques. Endovascular management of AVMs can be used for presurgical embolization, preradiosurgical intervention, or palliative embolization or as a primary treatment for curative embolization, depending on the characteristics of the lesion. Advances in endovascular management of acute stroke have further increased the therapeutic window of recombinant tissue plasminogen activator administration using the intraarterial route and have led to the introduction of new devices for clot removal and vessel recanalization.

scholarly journals A novel approach to oesophageal clot removal

2010 ◽  
Vol 92 (1) ◽  
pp. 75-76 ◽  
Author(s):  
C Abbott ◽  
A J Botha
Keyword(s):  
Clot Removal ◽  
Novel Approach

scholarly journals Predictors of Successful First-Pass Thrombectomy with a Balloon Guide Catheter: Results of a Decision Tree Analysis

2020 ◽  
Vol 11 (5) ◽  
pp. 900-909 ◽  
Author(s):  
Aglaé Velasco Gonzalez ◽  
Dennis Görlich ◽  
Boris Buerke ◽  
Nico Münnich ◽  
Cristina Sauerland ◽  
...  
Keyword(s):  
Decision Tree ◽  
Internal Carotid ◽  
Primary Objective ◽  
Supervised Machine Learning ◽  
Anterior Circulation ◽  
Clot Removal ◽  
Guide Catheter ◽  
First Pass ◽  
Distal Internal Carotid Artery ◽  
The One

Abstract Complete recanalization after a single retrieval maneuver is an interventional goal in acute ischemic stroke and an independent factor for good clinical outcome. Anatomical biomarkers for predicting clot removal difficulties have not been comprehensively analyzed and await unused. We retrospectively evaluated 200 consecutive patients who suffered acute stroke and occlusion of the anterior circulation and were treated with mechanical thrombectomy through a balloon guide catheter (BGC). The primary objective was to evaluate the influence of carotid tortuosity and BGC positioning on the one-pass Modified Thrombolysis in Cerebral Infarction Scale (mTICI) 3 rate, and secondarily, the influence of communicating arteries on the angiographic results. After the first-pass mTICI 3, recanalization fell from 51 to 13%. The regression models and decision tree (supervised machine learning) results concurred: carotid tortuosity was the main constraint on efficacy, reducing the likelihood of mTICI 3 after one pass to 30%. BGC positioning was relevant only in carotid arteries without elongation: BGCs located in the distal internal carotid artery (ICA) had a 70% probability of complete recanalization after one pass, dropping to 43% if located in the proximal ICA. These findings demonstrate that first-pass mTICI 3 is influenced by anatomical and interventional factors capable of being anticipated, enabling the BGC technique to be adapted to patient’s anatomy to enhance effectivity.

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