Secondary Brain Injury Mechanism of Hypothalamus—Pituitary—Adrenal Axis Neurohormonal Activation in Severely Brain-Injured Patients

2004 ◽  
pp. 55-67
Author(s):  
Nariyuki Hayashi ◽  
Dalton W. Dietrich
Keyword(s):  
Brain Injury ◽  
Injury Mechanism ◽  
Secondary Brain Injury ◽  
Neurohormonal Activation ◽  
Adrenal Axis ◽  
Brain Injured ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Injured Patients ◽  
Pituitary Adrenal Axis

Deciphering the Association Between Hypothalamus‐Pituitary‐Adrenal Axis Activity and Obesity: A Meta‐Analysis

Obesity ◽  
2021 ◽  
Author(s):  
Giada Ostinelli ◽  
Anaïs Scovronec ◽  
Sylvain Iceta ◽  
Anne‐Sophie Ouellette ◽  
Simone Lemieux ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Adrenal Axis ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

Contribution of Growth Arrest-Specific 5/miR-674 to the Hypothalamus Pituitary Adrenal Axis Regulation Effect by Electroacupuncture following Trauma

2021 ◽  
pp. 1-13
Author(s):  
Jing Zhu ◽  
Chunxia Guo ◽  
Pingping Lu ◽  
Shuijin Shao ◽  
Bing Tu
Keyword(s):  
Hpa Axis ◽  
Interleukin 1 ◽  
Growth Arrest ◽  
Luciferase Assay ◽  
Function Evaluation ◽  
Protein Levels ◽  
Adrenal Axis ◽  
Post Surgery ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

<b><i>Background:</i></b> Electroacupuncture (EA) can improve trauma-induced hypothalamus pituitary adrenal axis (HPA) hyperactivity. However, the mechanism underlying the EA effect has not been fully understood. <b><i>Methods and Study Design:</i></b> This study was undertaken to explore the role of hypothalamic growth arrest-specific 5 (Gas5) in the regulation of EA on HPA axis function post-surgery. Paraventricular nuclear Gas5 levels were upregulated in rats using an intracerebroventricular injection of pAAV-Gas5. Primary hypothalamic neurons and 293T cells were cultured for miRNA and siRNAs detection. Radioimmunoassay, PCR, Western blot, and immunohistochemistry were used for HPA axis function evaluation. <b><i>Results:</i></b> The overexpression of Gas5 abolished the effect of EA on the regulation of trauma-induced HPA axis hyperactivity. Using a bioinformatics analysis and dual luciferase assay, we determined that miRNA-674 was a target of Gas5. Additionally, miRNA-674 levels were found to have decreased in trauma rats, and this effect was reversed after EA intervention. TargetScan analysis showed that serum and glucocorticoid inducible kinase 1 (SGK1) were targets of miR-674. Moreover, we found that SGK1 protein levels increased in trauma rats and SGK1 expression inhibition alleviated HPA axis abnormality post-surgery. EA could improve the number of hypothalamus iba-1 positive cells and hypothalamic interleukin 1 beta protein expression. <b><i>Conclusions:</i></b> Our study demonstrated the involvement of the hypothalamic Gas5/miRNA-674/SGK1 signaling pathway in EA regulation of HPA axis function after trauma.

The function of hypothalamus–pituitary–adrenal axis in children with ADHD

2011 ◽  
Vol 1368 ◽  
pp. 159-162 ◽  
Author(s):  
Liang Ma ◽  
Yan-Hui Chen ◽  
Hui Chen ◽  
Yan-Yan Liu ◽  
Yan-Xia Wang
Keyword(s):  
Children With Adhd ◽  
Adrenal Axis ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Association of IL-6, Hypothalamus-Pituitary-Adrenal Axis Function, and Depression in Patients With Cancer

2010 ◽  
Vol 9 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Christian Friedrich Jehn ◽  
Dagmar Kühnhardt ◽  
Andrea Bartholomae ◽  
Sebastian Pfeiffer ◽  
Peter Schmid ◽  
...  
Keyword(s):  
Patients With Cancer ◽  
Adrenal Axis ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis

Impact of Childhood Trauma on Hypothalamus-Pituitary-Adrenal Axis Activity in Alcohol-Dependent Patients

2010 ◽  
Vol 16 (2) ◽  
pp. 108-114 ◽  
Author(s):  
Ingo Schäfer ◽  
Lisa Teske ◽  
Juliane Schulze-Thüsing ◽  
Katrin Homann ◽  
Jens Reimer ◽  
...  
Keyword(s):  
Childhood Trauma ◽  
Adrenal Axis ◽  
Hypothalamus Pituitary Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Alcohol Dependent
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