Graded activity in cognitieve gedragstherapie bij chronische pijnpatiënten

Pijn Info ◽  
2004 ◽  
pp. 527-533
Author(s):  
R. Maiori ◽  
A. J. A. Köke ◽  
M. Geilen ◽  
J. Van Zundert ◽  
K. C. P. Vissers
Keyword(s):  
Cognitieve Gedragstherapie ◽  
Graded Activity

scholarly journals Interpretation of the Repetitive Firing of Nerve Cells

1962 ◽  
Vol 45 (6) ◽  
pp. 1163-1179 ◽  
Author(s):  
M. G. F. Fuortes ◽  
Francoise Mantegazzini
Keyword(s):  
Nerve Cells ◽  
Principal Factor ◽  
Current Intensity ◽  
Moderate Intensity ◽  
Repetitive Firing ◽  
Important Process ◽  
Current Step ◽  
After Effects ◽  
Graded Activity ◽  
A Current

Eccentric cells of Limulus respond with repetitive firing to sustained depolarizing currents. Following stimulation with a step of current, latency is shorter than first interval and later intervals increase progressively. A shock of intensity twice threshold can evoke firing 25 msec. after an impulse. But in the same cell, a current step twice rheobase evokes a second impulse more than 50 msec. after the first, and current intensity must be raised to over five times rheobase to obtain a first interval of about 25 msec. Repetitive firing was evoked by means of trains of shocks. With stimuli of moderate intensity, firing was evoked by only some of the shocks and intervals between successive impulses increased with time. This is ascribed to accumulation of refractoriness with successive impulses. Higher frequencies of firing are obtained with shocks of intensity n x threshold than with constant currents of intensity n x rheobase. It is concluded that prolonged currents depress the processes leading to excitation and that (in the cells studied) repetitive firing is controlled both by the after-effects of firing (refractoriness) and by the depressant effects of sustained stimuli (accommodation). Development of subthreshold "graded activity" is an important process leading to excitation of eccentric cells, but is not the principal factor determining frequency of firing in response to constant currents.

scholarly journals The cost effectiveness of behavioural graded activity in patients with osteoarthritis of hip and/or knee

2006 ◽  
Vol 66 (2) ◽  
pp. 215-221 ◽  
Author(s):  
V. M H Coupe ◽  
C. Veenhof ◽  
M. W van Tulder ◽  
J. Dekker ◽  
J. W J Bijlsma ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Graded Activity ◽  
The Cost ◽  
Osteoarthritis Of Hip

Op mindfulness gebaseerde cognitieve gedragstherapie

2010 ◽  
Vol 2 (3) ◽  
pp. 17-19 ◽  
Author(s):  
Monique Hulsbergen
Keyword(s):  
Cognitieve Gedragstherapie

Specification of the embryonic limb primordium by graded activity of Decapentaplegic

Development ◽  
1997 ◽  
Vol 124 (1) ◽  
pp. 125-132 ◽  
Author(s):  
S. Goto ◽  
S. Hayashi
Keyword(s):  
Imaginal Disc ◽  
Egf Receptor ◽  
Lateral Position ◽  
Negative Control ◽  
Dependent Manner ◽  
Additional Cell ◽  
Embryonic Limb ◽  
Graded Activity ◽  
Limb Pattern ◽  
Late Function

Two thoracic limbs of Drosophila, the leg and the wing, originate from a common cluster of cells that include the source of two secreted signaling molecules, Decapentaplegic and Wingless. We show that Wingless, but not Decapentaplegic, is responsible for initial specification of the limb primordia with a distal identity. Limb formation is restricted to the lateral position of the embryo by negative control of the early function of Decapentaplegic and the EGF receptor homolog that determine the global dorsoventral pattern. Late function of Decapentaplegic locally determines two additional cell identities in a dosage dependent manner. Loss of Decapentaplegic activity results in a deletion of the proximal structures of the limb, which is in contrast to the consequence of decapentaplegic mutations in the imaginal disc, which cause a deletion of distal structures. The results indicate that the limb pattern elements are added in a distal to proximal direction in the embryo, which is opposite to what is happening in the growing imaginal disc. We propose that Wingless and Decapentaplegic act sequentially to initiate the proximodistal axis.

EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

Development ◽  
1996 ◽  
Vol 122 (11) ◽  
pp. 3355-3362 ◽  
Author(s):  
L. Gabay ◽  
H. Scholz ◽  
M. Golembo ◽  
A. Klaes ◽  
B.Z. Shilo ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Target Genes ◽  
Egf Receptor ◽  
Protein A ◽  
Drosophila Embryo ◽  
Cell Fates ◽  
Secondary Target ◽  
Graded Activity ◽  
Definition Of

The induction of different cell fates along the dorsoventral axis of the Drosophila embryo requires a graded activity of the EGF receptor tyrosine kinase (DER). Here we have identified primary and secondary target genes of DER, which mediate the determination of discrete ventral cell fates. High levels of DER activation in the ventralmost cells trigger expression of the transcription factors encoded by ventral nervous system defective (vnd) and pointed P1 (pntPl). Concomitant with the induction of pntP1, high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan. The simultaneous effects of the DER pathway on pntP1 induction and Yan inactivation may contribute to the definition of the border of the ventralmost cell fates.

scholarly journals Phosphoregulation of the intracellular termini of K+-Cl− cotransporter 2 (KCC2) enables flexible control of its activity

2018 ◽  
Vol 293 (44) ◽  
pp. 16984-16993 ◽  
Author(s):  
Antje Cordshagen ◽  
Wiebke Busch ◽  
Michael Winklhofer ◽  
Hans Gerd Nothwang ◽  
Anna-Maria Hartmann
Keyword(s):  
Intrinsic Activity ◽  
Hek 293 ◽  
Flexible Control ◽  
Mediated Effects ◽  
293 Cells ◽  
Bona Fide ◽  
Graded Activity ◽  
First Time ◽  
Increased Activity

The pivotal role of K+-Cl− cotransporter 2 (KCC2) in inhibitory neurotransmission and severe human diseases fosters interest in understanding posttranslational regulatory mechanisms such as (de)phosphorylation. Here, the regulatory role of the five bona fide phosphosites Ser31, Thr34, Ser932, Thr999, and Thr1008 was investigated by the use of alanine and aspartate mutants. Tl+-based flux analyses in HEK-293 cells demonstrated increased transport activity for S932D (mimicking phosphorylation) and T1008A (mimicking dephosphorylation), albeit to a different extent. Increased activity was due to changes in intrinsic activity, as it was not caused by increased cell-surface abundance. Substitutions of Ser31, Thr34, or Thr999 had no effect. Additionally, we show that the indirect actions of the known KCC2 activators staurosporine and N-ethylmaleimide (NEM) involved multiple phosphosites. S31D, T34A, S932A/D, T999A, or T1008A/D abrogated staurosporine mediated stimulation, and S31A, T34D, or S932D abolished NEM-mediated stimulation. This demonstrates for the first time differential effects of staurosporine and NEM on KCC2. In addition, the staurosporine-mediated effects involved both KCC2 phosphorylation and dephosphorylation with Ser932 and Thr1008 being bona fide target sites. In summary, our data reveal a complex phosphoregulation of KCC2 that provides the transporter with a toolbox for graded activity and integration of different signaling pathways.

Which patientswith osteoarthritis of hip and/or knee benefit most from behavioral graded activity?

2007 ◽  
Vol 14 (2) ◽  
pp. 86-91 ◽  
Author(s):  
Cindy Veenhof ◽  
Cornelia HM Van den Ende ◽  
Joost Dekker ◽  
Albère Ja. Köke ◽  
Rob A Oostendorp ◽  
...  
Keyword(s):  
Graded Activity ◽  
Osteoarthritis Of Hip

Cardiovascular responses to graded activity in the lizards Varanus and Iguana

1980 ◽  
Vol 239 (1) ◽  
pp. R174-R179 ◽  
Author(s):  
T. T. Gleeson ◽  
G. S. Mitchell ◽  
A. F. Bennett
Keyword(s):  
Cardiovascular Responses ◽  
Graded Activity

scholarly journals Graded Activity and Graded Exposure for Persistent Nonspecific Low Back Pain: A Systematic Review

2010 ◽  
Vol 90 (6) ◽  
pp. 860-879 ◽  
Author(s):  
Luciana G. Macedo ◽  
Rob J.E.M. Smeets ◽  
Christopher G. Maher ◽  
Jane Latimer ◽  
James H. McAuley
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Confidence Intervals ◽  
Controlled Trials ◽  
Low Back ◽  
Short Term ◽  
Minimal Intervention ◽  
Randomized Controlled ◽  
Graded Exposure ◽  
Graded Activity

Background Graded activity and graded exposure are increasingly being used in the management of persistent low back pain; however, their effectiveness remains poorly understood. Purpose The aim of this study was to systematically review randomized controlled trials that evaluated the effectiveness of graded activity or graded exposure for persistent (>6 weeks in duration or recurrent) low back pain. Data Sources Trials were electronically searched and rated for quality by use of the PEDro scale (values of 0–10). Study Selection Randomized controlled trials of graded activity or graded exposure that included pain, disability, global perceived effect, or work status outcomes were included in the study. Data Extraction Outcomes were converted to a scale from 0 to 100. Trials were pooled with software used for preparing and maintaining Cochrane reviews. Results are presented as weighted mean differences with 95% confidence intervals. Data Synthesis Fifteen trials with 1,654 patients were included. The trials had a median quality score of 6 (range=3–9). Pooled effects from 6 trials comparing graded activity with a minimal intervention or no treatment favored graded activity, with 4 contrasts being statistically significant: mean values (95% confidence intervals) for pain in the short term, pain in the intermediate term, disability in the short term, and disability in the intermediate term were −6.2 (−9.4 to −3.0), −5.5 (−9.9 to −1.0), −6.5 (−10.1 to −3.0), and −3.9 (−7.4 to −0.4), respectively. None of the pooled effects from 6 trials comparing graded activity with another form of exercise, from 4 trials comparing graded activity with graded exposure, and from 2 trials comparing graded exposure with a waiting list were statistically significant. Limitations Limitations of this review include the low quality of the studies, primarily those that evaluated graded exposure; the use of various types of outome measures; and differences in the implementation of the interventions, adding to the heterogeneity of the studies. Conclusions The available evidence suggests that graded activity in the short term and intermediate term is slightly more effective than a minimal intervention but not more effective than other forms of exercise for persistent low back pain. The limited evidence suggests that graded exposure is as effective as minimal treatment or graded activity for persistent low back pain.

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