Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications

2012 ◽  
pp. 187-205
Author(s):  
Luis Martí-Bonmatí ◽  
A. Alberich-Bayarri
Keyword(s):  
Mr Spectroscopy ◽  
Clinical Applications ◽  
Disease Biomarkers

scholarly journals Current Status and Future Prospects of Proton MR Spectroscopy of the Breast with a 1.5T MR Unit

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Mitsuhiro Tozaki ◽  
Katsuya Maruyama
Keyword(s):  
Mammary Gland ◽  
Clinical Practice ◽  
Clinical Data ◽  
Mr Spectroscopy ◽  
Basic Research ◽  
Clinical Applications ◽  
Current Status ◽  
Future Prospects ◽  
Proton Mr Spectroscopy ◽  
Malignant Lesions

Proton MR spectroscopy of the mammary gland area is used to be considered in the realm of basic research, but as a result of the advances in MR techniques, it is now being performed in ordinary clinical practice. It is particularly noteworthy that useful clinical data are now being accumulated with 1.5T MR units, which are the standard units. We think that, at this point, it is very important to systematically review the techniques, clinical applications, and future prospects of proton MR spectroscopy. We have performed proton MR spectroscopy with a 1.5T MR unit in over 3000 cases at our hospital. In this paper, we will comment on the current status of proton MR spectroscopy of the breast, primarily in regard to differentiation between benign and malignant lesions and prediction of the efficacy of chemotherapy while describing the data obtained at our hospital.

scholarly journals Proton MR spectroscopy in the breast: Technical innovations and clinical applications

2019 ◽  
Vol 50 (4) ◽  
pp. 1033-1046 ◽  
Author(s):  
Reza Fardanesh ◽  
Maria Adele Marino ◽  
Daly Avendano ◽  
Doris Leithner ◽  
Katja Pinker ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Clinical Applications ◽  
Proton Mr Spectroscopy ◽  
Technical Innovations

scholarly journals Clinical applications of proton MR spectroscopy in the diagnosis of brain tumours

2004 ◽  
Vol 18 (2) ◽  
pp. 143-153 ◽  
Author(s):  
Nail Bulakbasi
Keyword(s):  
Mr Spectroscopy ◽  
Brain Tumours ◽  
Radiation Necrosis ◽  
Signal To Noise Ratio ◽  
Brain Parenchyma ◽  
Clinical Applications ◽  
Exact Nature ◽  
Physiological Changes ◽  
Definition Of ◽  
The Brain

There are few but important problems in magnetic resonance (MR) diagnosis of the brain tumours such as predicting the grade, exact definition of the tumour borders, differentiation of the cystic tumours from abscess, the tumoral core from peritumoral oedema, and the tumour recurrence from radiation necrosis. MR spectroscopy (MRS) can add more information to MR imaging (MRI) in solving many of these problems. Widespread usage of faster MRS applications with higher signal‒to‒noise ratio (SNR) and spatial resolution, allows us to detect functional metabolic changes, which provides more data to understand the exact nature of the tumour and the morphological and physiological changes occurring in the surrounding brain parenchyma.

MR spectroscopy: Clinical applications and techniques

Radiography ◽  
1996 ◽  
Vol 2 (1) ◽  
pp. 77-78 ◽  
Author(s):  
S.J. Blackband
Keyword(s):  
Mr Spectroscopy ◽  
Clinical Applications

Non-invasive quantification of lactate by proton MR spectroscopy and its clinical applications

2005 ◽  
Vol 107 (5) ◽  
pp. 379-384 ◽  
Author(s):  
Akira Matsumura ◽  
Tomonori Isobe ◽  
Shingo Takano ◽  
Hiraku Kawamura ◽  
Izumi Anno
Keyword(s):  
Mr Spectroscopy ◽  
Clinical Applications ◽  
Proton Mr Spectroscopy ◽  
Non Invasive

scholarly journals Small Extracellular Vesicles: Functions and Potential Clinical Applications as Cancer Biomarkers

Life ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1044
Author(s):  
Yi Wang ◽  
Ruichen Zhao ◽  
Xueqiao Jiao ◽  
Longyuan Wu ◽  
Yuxuan Wei ◽  
...  
Keyword(s):  
Public Health ◽  
Extracellular Vesicles ◽  
Cancer Biomarkers ◽  
Clinical Applications ◽  
Dynamic Monitoring ◽  
Health Concern ◽  
Public Health Concern ◽  
Disease Biomarkers ◽  
Potential Applications ◽  
Protein Nucleic Acid

Cancer, as the second leading cause of death worldwide, is a major public health concern that imposes a heavy social and economic burden. Effective approaches for either diagnosis or therapy of most cancers are still lacking. Dynamic monitoring and personalized therapy are the main directions for cancer research. Cancer-derived extracellular vesicles (EVs) are potential disease biomarkers. Cancer EVs, including small EVs (sEVs), contain unique biomolecules (protein, nucleic acid, and lipids) at various stages of carcinogenesis. In this review, we discuss the biogenesis of sEVs, and their functions in cancer, revealing the potential applications of sEVs as cancer biomarkers.

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