Persistent Infection of Mice with Lymphocytic Choriomeningitis Virus

1988 ◽  
pp. 69-83 ◽  
Author(s):  
F. Lehmann-Grube
Keyword(s):  
Persistent Infection ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus

Infectious Lymphocytes in Mice Persistently Infected with Lymphocytic Choriomeningitis Virus

1977 ◽  
Vol 32 (11-12) ◽  
pp. 1026-1028 ◽  
Author(s):  
Mircea Popescu ◽  
Jürgen Löhler ◽  
Fritz Lehmann-Grube
Keyword(s):  
Persistent Infection ◽  
Viral Antigen ◽  
Infectious Virus ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Mononuclear Phagocytes ◽  
Infectious Process ◽  
Persistently Infected ◽  
Infected Cells ◽  
Virus Carrier

Abstract During persistent infection of mice with the lymphocytic choriomeningitis (LCM) virus approximately 3% of leukocytes were found to contain viral antigen and to produce infectious virus. Morphologically, infected cells were shown not to be lymphoblasts and their numbers were not reduced by removal of mononuclear phagocytes. We conclude that in LCM virus carrier mice true lymphocytes participate in the infectious process.

scholarly journals Altered Central Nervous System Gene Expression Caused by Congenitally Acquired Persistent Infection with Lymphocytic Choriomeningitis Virus

2006 ◽  
Vol 80 (18) ◽  
pp. 9082-9092 ◽  
Author(s):  
Stefan Kunz ◽  
Jillian M. Rojek ◽  
Amanda J. Roberts ◽  
Dorian B. McGavern ◽  
Michael B. A. Oldstone ◽  
...  
Keyword(s):  
Gene Expression ◽  
Central Nervous System ◽  
Nervous System ◽  
Persistent Infection ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Cns Infection ◽  
Mouse Strains ◽  
Viral Spread ◽  
The Impact

ABSTRACT Neonatal infection of most mouse strains with lymphocytic choriomeningitis virus (LCMV) leads to a life-long persistent infection characterized by high virus loads in the central nervous system (CNS) in the absence of inflammation and tissue destruction. These mice, however, exhibit impaired learning and memory. The occurrence of cognitive defects in the absence of overt CNS pathology led us to the hypothesis that chronic virus infection may contribute to neuronal dysfunction by altering the host's gene expression profile. To test this hypothesis, we examined the impact of LCMV persistence on host gene expression in the CNS. To model the natural route of human congenital CNS infection observed with a variety of viruses, we established a persistently infected mouse colony where the virus was maintained via vertical transmission from infected mothers to offspring (LCMV-cgPi). LCMV-cgPi mice exhibited a lifelong persistent infection involving the CNS; the infection was associated with impaired spatial-temporal learning. Despite high viral loads in neurons of the brains of adult LCMV-cgPi mice, we detected changes in the host's CNS gene expression for only 75 genes, 56 and 19 being significantly induced and reduced, respectively. The majority of the genes induced in the brain of LCMV-cgPi mice were interferon (IFN)-stimulated genes (ISGs) and included the transcription factors STAT1 and IRF9, the ISG15 protease UBP43, and the glucocorticoid attenuated-response genes GARG16 and GARG49. Based on their crucial role in antiviral defense, these ISGs may play an important role in limiting viral spread and replication. However, since IFNs have also been implicated in adverse effects on neuronal function, the chronic induction of some ISGs may also contribute to the observed cognitive impairment.

scholarly journals Hypoxic marker CA IX and adhesion mediator β-catenin are downregulated by lymphocytic choriomeningitis virus persistent infection

Oncotarget ◽  
2018 ◽  
Vol 9 (16) ◽  
pp. 12879-12893
Author(s):  
Andrea Fabianova ◽  
Monika Barathova ◽  
Lucia Csaderova ◽  
Veronika Simko ◽  
Miriam Zatovicova ◽  
...  
Keyword(s):  
Persistent Infection ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Ca Ix

Enhanced resistance to arboviruses of mice with persistent lymphocytic choriomeningitis virus infection

1969 ◽  
Vol 15 (12) ◽  
pp. 1468-1469 ◽  
Author(s):  
Vester Lewis ◽  
Diane Clayton
Keyword(s):  
Public Health ◽  
Virus Infection ◽  
Persistent Infection ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Enhanced Resistance ◽  
Public Health Significance ◽  
Health Significance ◽  
Lymphocytic Choriomeningitis Virus Infection

Mice with persistent infection by lymphocytic choriomeningitis virus were shown to be slightly more resistant than uninfected mice to three arboviruses of public health significance.

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