Intracellular Calcium Concentration Following Length Changes in Mammalian Cardiac Muscle

1988 ◽  
pp. 28-42 ◽  
Author(s):  
D. G. Allen ◽  
G. L. Smith ◽  
C. G. Nichols
Keyword(s):  
Intracellular Calcium ◽  
Cardiac Muscle ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration ◽  
Length Changes

Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells

Phytomedicine ◽  
2010 ◽  
Vol 17 (12) ◽  
pp. 980-986 ◽  
Author(s):  
A.P. Simões-Wüst ◽  
M. Grãos ◽  
C.B. Duarte ◽  
R. Brenneisen ◽  
M. Hamburger ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration ◽  
Myometrial Cells ◽  
Bryophyllum Pinnatum

β-Amyloid-induced increase in the resting intracellular calcium concentration gives support to tell Alzheimer lymphocytes from control ones

2002 ◽  
Vol 58 (2) ◽  
pp. 203-205 ◽  
Author(s):  
András Palotás ◽  
János Kálmán ◽  
Miklós Palotás ◽  
Anna Juhász ◽  
Zoltán Janka ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration ◽  
Β Amyloid

Effects of low level laser irradiation on cell cycle and intracellular calcium concentration of osteoblastic cells under mechanical strain

2015 ◽  
Vol 23 (7) ◽  
pp. 1984-1989
Author(s):  
史瑞新 SHI Rui-xin ◽  
周延民 ZHOU Yan-min ◽  
胡敏 HU Min ◽  
陈远萍 CHEN Yuan-ping ◽  
庄金良 ZHUANG Jin-liang
Keyword(s):  
Cell Cycle ◽  
Intracellular Calcium ◽  
Laser Irradiation ◽  
Calcium Concentration ◽  
Mechanical Strain ◽  
Intracellular Calcium Concentration ◽  
Osteoblastic Cells ◽  
Low Level Laser ◽  
Level Laser ◽  
Low Level Laser Irradiation

Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the millimolar range

1995 ◽  
Vol 74 (6) ◽  
pp. 2625-2637 ◽  
Author(s):  
N. E. Ziv ◽  
M. E. Spira
Keyword(s):  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration ◽  
Concentration Gradients ◽  
Fura 2 ◽  
Direct Demonstration ◽  
Free Intracellular Calcium ◽  
Axonal Transection ◽  
Transient Elevation

1. Axonal transection triggers a cascade of pathological processes that frequently lead to the degeneration of the injured neuron. It is generally believed that the degenerative process is triggered by an overwhelming influx of calcium through the cut end of the axon. 2. Theoretical considerations and indirect observations suggest that axotomy is followed by an increase in the free intracellular calcium concentration ([Ca2+]i) to the millimolar level. In contrast, only relatively modest and transient elevation in [Ca2+]i to the micromolar level was revealed by recent fura-2 studies. 3. In the current study we used the low-affinity Ca2+ indicator mag-fura-2 to reexamine the spatiotemporal distribution pattern of Ca2+ after axotomy and to map the free intracellular Mg2+ concentration gradients. 4. We report that axotomy elevates [Ca2+]i well beyond the "physiological" range of calcium concentrations, to levels > 1 mM near the tip of the cut axon and to hundreds of micromolars along the axon further away from the cut end. Nevertheless, [Ca2+]i recovers to the control levels within 2-3 min after the resealing of the cut end. 5. A comparison of the behavior of fura-2 and mag-fura-2 in the cytosol of the axotomized neurons reveals that the determination of [Ca2+]i by fura-2 largely underestimates the actual intracellular Ca2+ concentrations. 6. Experiments in which one branch of a bifurcated axon was transected revealed that the elevation in [Ca2+]i is confined to the transected axonal branch and does not spread beyond the bifurcation point. 7. After axotomy, the intracellular Mg2+ concentration equilibrates rapidly with the external concentration and then recovers at a rate somewhat slower than that of [Ca2+]i. 8. To the best of our knowledge, this study is the first direct demonstration that axotomy elevates [Ca2+]i to the millimolar range and that neurons are able to recover from these extreme calcium concentrations.

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