Local oral immunisation with synthetic peptides induces a dual mucosal IgG and salivary IgA antibody response and prevents colonisation of Streptococcus mutans

1990 ◽  
pp. 336-339
Author(s):  
L A Bergmeier ◽  
T Lehner ◽  
J Haron
Keyword(s):  
Antibody Response ◽  
Streptococcus Mutans ◽  
Synthetic Peptides ◽  
Salivary Iga ◽  
Oral Immunisation ◽  
Iga Antibody ◽  
Mucosal Igg

scholarly journals Antibody to Glucosyltransferase Induced by Synthetic Peptides Associated with Catalytic Regions of α-Amylases

1999 ◽  
Vol 67 (5) ◽  
pp. 2638-2642 ◽  
Author(s):  
Daniel J. Smith ◽  
Rhonda L. Heschel ◽  
William F. King ◽  
Martin A. Taubman
Keyword(s):  
Catalytic Activity ◽  
Immune Responses ◽  
Streptococcus Mutans ◽  
Immunoglobulin G ◽  
Inhibitory Activity ◽  
Synthetic Peptides ◽  
Serum Immunoglobulin ◽  
Salivary Iga ◽  
Glucan Synthesis

ABSTRACT We examined the immunogenicity and induction of inhibitory activity of 19-mer synthetic peptides which contained putative catalytic regions that were associated with the β5 (EAW) and β7 (HDS) strand elements of the suggested (β,α)8 catalytic barrel domain of Streptococcus mutans glucosyltransferase (GTF). Both peptides readily induced serum immunoglobulin G (IgG) and salivary IgA antipeptide activity which was reactive both with the inciting peptide and with intactS. mutans GTF. Antisera to each peptide construct also inhibited the ability of S. mutans GTF to synthesize glucan. These observations support the existence of catalytic subdomains containing glutamate and tryptophan (EAW) or aspartate and histidine (HDS) residues, each of which have been suggested to be involved with the catalytic activity of GTF. Furthermore, the epitopes defined in these sequences have significant immunogenicity and can induce immune responses which interfere with GTF-mediated glucan synthesis.

scholarly journals Characterization of Salivary Immunoglobulin A Responses in Children Heavily Exposed to the Oral Bacterium Streptococcus mutans: Influence of Specific Antigen Recognition in Infection

2005 ◽  
Vol 73 (9) ◽  
pp. 5675-5684 ◽  
Author(s):  
Ruchele D. Nogueira ◽  
Alessandra C. Alves ◽  
Marcelo H. Napimoga ◽  
Daniel J. Smith ◽  
Renata O. Mattos-Graner
Keyword(s):  
Streptococcus Mutans ◽  
Specific Antigen ◽  
Immunoglobulin A ◽  
Salivary Iga ◽  
Racial Background ◽  
Tooth Surfaces ◽  
Natural Response ◽  
Iga Antibody ◽  
Antibody Specificities ◽  
Salivary Immunoglobulin A

ABSTRACT The initial infection of children by Streptococcus mutans, the main pathogen of dental caries, depends on the ability of S. mutans to adhere and accumulate on tooth surfaces. These processes involve the adhesin antigen I/II (AgI/II), glucosyltransferases (GTF) and glucan-binding protein B (GbpB), each a target for anticaries vaccines. The salivary immunoglobulin A (IgA) antibody responses to S. mutans antigens (Ags) were characterized in 21 pairs of 5- to 13-month-old children. Pairs were constructed with one early S. mutans-infected and one noninfected child matched by age, racial background, number of teeth, and salivary levels of IgA. Specific salivary IgA antibody response and S. mutans infection levels were then measured during a 1-year follow-up. Robust responses to S. mutans were detected from 6 months of age. Salivary IgA antibody to AgI/II and GTF was commonly detected in salivas of all 42 children. However, GbpB-specific IgA antibody was seldom detected in the subset of infected children (38.1% at baseline). In contrast, most of the subset of noninfected children (76.2%) showed GbpB-reactive IgA antibody during the same period. Frequencies of GbpB responses increased with age, but differences in intensities of GbpB-IgA antibody reactions were sustained between the subsets. At baseline, GbpB-reactive IgA antibody accounted for at least half of the total salivary IgA S. mutans-reactive antibody in 33.3 and 9.5% of noninfected and infected children, respectively. This study provides evidence that a robust natural response to S. mutans Ags can be achieved by 1 year of age and that IgA antibody specificities may be critical in modulating initial S. mutans infection.

scholarly journals Salivary IgA antibody responses to Streptococcus mitis and Streptococcus mutans in preterm and fullterm newborn children

2012 ◽  
Vol 57 (6) ◽  
pp. 647-653 ◽  
Author(s):  
Ruchele Dias Nogueira ◽  
Maria Lucia Talarico Sesso ◽  
Mariana Castro Loureiro Borges ◽  
Renata O. Mattos-Graner ◽  
Daniel James Smith ◽  
...  
Keyword(s):  
Streptococcus Mutans ◽  
Antibody Responses ◽  
Streptococcus Mitis ◽  
Salivary Iga ◽  
Iga Antibody ◽  
Newborn Children

scholarly journals Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood

2016 ◽  
Vol 67 ◽  
pp. 22-27 ◽  
Author(s):  
Natália Helena Colombo ◽  
Jesse Augusto Pereira ◽  
Márjully Eduardo Rodrigues da Silva ◽  
Laís Fernanda Fonseca Ribas ◽  
Thaís Manzano Parisotto ◽  
...  
Keyword(s):  
Dental Caries ◽  
Antibody Response ◽  
Streptococcus Mutans ◽  
Iga Antibody

Secretory IgA antibody response against Escherichia coli antigens in infants in relation to exposure

1985 ◽  
Vol 107 (3) ◽  
pp. 430-433 ◽  
Author(s):  
L. Mellander ◽  
B. Carlsson ◽  
Fehmida Jalil ◽  
T. Söderström ◽  
L.Å. Hanson
Keyword(s):  
Escherichia Coli ◽  
Antibody Response ◽  
Secretory Iga ◽  
Iga Antibody

scholarly journals Salivary IgA antibody to Bacteroides gingivalis and Actinobacillus actinomycetemcomitans in patients with adult marginal periodontitis.

1987 ◽  
Vol 37 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Makoto SATO ◽  
Atsushi NAGATA ◽  
Reiko MAEHARA ◽  
Junko ENDO ◽  
Daisuke HINODE ◽  
...  
Keyword(s):  
Actinobacillus Actinomycetemcomitans ◽  
Salivary Iga ◽  
Iga Antibody ◽  
Bacteroides Gingivalis ◽  
Marginal Periodontitis
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