CDK-related protein kinases in plants

2000 ◽  
pp. 63-76 ◽  
Author(s):  
Jérôme Joubès ◽  
Christian Chevalier ◽  
Denes Dudits ◽  
Erwin Heberle-Bors ◽  
Dirk Inzé ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Related Protein

scholarly journals The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

Oncogene ◽  
1998 ◽  
Vol 17 (15) ◽  
pp. 1893-1901 ◽  
Author(s):  
Wolf Oehrl ◽  
Christian Kardinal ◽  
Sandra Ruf ◽  
Knut Adermann ◽  
John Groffen ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Germinal Center ◽  
Adapter Proteins ◽  
Related Protein ◽  
Signal Transducers

scholarly journals SNF1-related Protein Kinases 2 Are Negatively Regulated by a Plant-specific Calcium Sensor

2010 ◽  
Vol 286 (5) ◽  
pp. 3429-3441 ◽  
Author(s):  
Maria Bucholc ◽  
Arkadiusz Ciesielski ◽  
Grażyna Goch ◽  
Anna Anielska-Mazur ◽  
Anna Kulik ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Calcium Sensor ◽  
Related Protein

Cell Cycle-Related Protein Kinases and T Cell Death

1995 ◽  
pp. 247-258 ◽  
Author(s):  
Jill M. Lahti ◽  
Jialing Xiang ◽  
Vincent J. Kidd
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
T Cell ◽  
Protein Kinases ◽  
Related Protein

scholarly journals Targeting autophagy-related protein kinases for potential therapeutic purpose

2020 ◽  
Vol 10 (4) ◽  
pp. 569-581 ◽  
Author(s):  
Honggang Xiang ◽  
Jifa Zhang ◽  
Congcong Lin ◽  
Lan Zhang ◽  
Bo Liu ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Related Protein ◽  
Therapeutic Purpose

Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors

MedChemComm ◽  
2016 ◽  
Vol 7 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Maud Antoine ◽  
Tilmann Schuster ◽  
Irene Seipelt ◽  
Babette Aicher ◽  
Michael Teifel ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinases ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
Related Protein ◽  
Efficient Synthesis ◽  
Aniline Derivatives

Urea and aniline derivatives were active at low micromomolar IC50 values against a panel of seven cancer-related protein kinases.

The Sucrose Non-Fermenting 1-Related Protein Kinase 2 (SnRK2) Genes Are Multifaceted Players in Plant Growth, Development and Response to Environmental Stimuli

2019 ◽  
Vol 61 (2) ◽  
pp. 225-242 ◽  
Author(s):  
Xinguo Mao ◽  
Yuying Li ◽  
Shoaib Ur Rehman ◽  
Lili Miao ◽  
Yanfei Zhang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinases ◽  
Specific Protein ◽  
Regulatory Mechanisms ◽  
Biological Processes ◽  
Related Protein ◽  
Biological Functions ◽  
Reversible Protein Phosphorylation ◽  
Growth Development ◽  
Regulatory Event

Abstract Reversible protein phosphorylation orchestrated by protein kinases and phosphatases is a major regulatory event in plants and animals. The SnRK2 subfamily consists of plant-specific protein kinases in the Ser/Thr protein kinase superfamily. Early observations indicated that SnRK2s are mainly involved in response to abiotic stress. Recent evidence shows that SnRK2s are multifarious players in a variety of biological processes. Here, we summarize the considerable knowledge of SnRK2s, including evolution, classification, biological functions and regulatory mechanisms at the epigenetic, post-transcriptional and post-translation levels.

scholarly journals The Snf1‐related protein kinases SnRK2.4 and SnRK2.10 are involved in maintenance of root system architecture during salt stress

2012 ◽  
Vol 72 (3) ◽  
pp. 436-449 ◽  
Author(s):  
Fionn McLoughlin ◽  
Carlos S. Galvan‐Ampudia ◽  
Magdalena M. Julkowska ◽  
Lotte Caarls ◽  
Dieuwertje van der Does ◽  
...  
Keyword(s):  
Salt Stress ◽  
Root System ◽  
Protein Kinases ◽  
System Architecture ◽  
Root System Architecture ◽  
Related Protein

scholarly journals Activation of Extracellular Signal-Related Protein Kinases 1 and 2 of the Mitogen-Activated Protein Kinase Family by Lipopolysaccharide Requires Plasma in Neutrophils from Adults and Newborns

2001 ◽  
Vol 69 (5) ◽  
pp. 3143-3149 ◽  
Author(s):  
S. Bonner ◽  
S. R. Yan ◽  
D. M. Byers ◽  
R. Bortolussi
Keyword(s):  
Protein Kinase ◽  
Protein Kinases ◽  
Oxidative Burst ◽  
Mitogen Activated Protein Kinase ◽  
Related Protein ◽  
Extracellular Signal ◽  
Oxidative Response ◽  
Mitogen Activated Protein ◽  
Mediated Priming

ABSTRACT Neutrophils exposed to low concentrations of gram-negative lipopolysaccharide (LPS) become primed and have an increased oxidative response to a second stimulus (e.g., formyl-methionyl-leucyl-phenylalanine [fMLP]). In studies aimed at understanding newborn sepsis, we have shown that neutrophils of newborns are not primed in response to LPS. To further understand the processes involved in LPS-mediated priming of neutrophils, we explored the role of extracellular signal-related protein kinases (ERK 1 and 2) of the mitogen-activated protein kinase family. We found that LPS activated ERK 1 and 2 in cells of both adults and newborns and that activation was plasma dependent (maximal at ≥5%) through LPS-binding protein. Although fibronectin in plasma is required for LPS-mediated priming of neutrophils of adults assessed by fMLP-triggered oxidative burst, it was not required for LPS-mediated activation of ERK 1 and 2. LPS-mediated activation was dose and time dependent; maximal activation occurred with approximately 5 ng of LPS per ml and at 10 to 40 min. We used the inhibitor PD 98059 to study the role of ERK 1 and 2 in the LPS-primed fMLP-triggered oxidative burst. While Western blotting showed that 100 μM PD 98059 completely inhibited LPS-mediated ERK activation, oxidative response to fMLP by a chemiluminescence assay revealed that the same concentration inhibited the LPS-primed oxidative burst by only 40%. We conclude that in neutrophils, LPS-mediated activation of ERK 1 and 2 requires plasma and that this activation is not dependent on fibronectin. In addition, we found that the ERK pathway is not responsible for the lack of LPS priming in neutrophils of newborns but may be required for 40% of the LPS-primed fMLP-triggered oxidative burst in cells of adults.

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