Overview of Placenta Pathology

Abstract Introduction/Objective Stillbirth is defined as fetal death that occurs at gestational age of ≥28 weeks. In our setting clinical assessment is the only method used to determine cause of stillbirths, with no reported proportion of unknown clinical diagnosis. Studies showed that unknown cause of stillbirths can be reduced by examination of placenta. Causal identification aids in the mourning process and identifying recurrence risks. The study aimed to describe pathological changes in the placentas of stillbirths which have risk to cause fetal death Methods A descriptive cross-sectional study done for the period of 6 months, it involved examination of 80 placentas of stillbirths born at gestational age of ≥ 28 weeks, placentas were fixed in 10% neutral buffered formalin for 8–12 hours. Grossing and interpretation of placenta pathology was according to Amsterdam Placental Workshop Group Consensus Statement. Results Out of 80 stillbirths, 32(40%) had unknown clinical diagnosis. Majority of stillbirth placentas 71(91%) found with either one or combined pathologies with the risk to cause stillbirth. Maternal vascular malperfusion was the commonest pathology and was significantly associated with preterm stillbirths. Maternal floor infarction, a placenta pathology with risk to cause fetal death and high risk of recurrence was among the pathologies found, was seen in 4(5%) of stillbirth placentas. Conclusion Findings in this study clearly indicated the importance of pathological examination of placenta in determining cause of stillbirth. Placenta examination in stillbirths can identify more pathology related to stillbirths than clinical assessment alone.

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The use of placenta pathology to identify women at high-risk of cardiovascular disease following preeclampsia

Canadian Journal of Cardiology ◽

10.1016/j.cjca.2020.02.010 ◽

2021 ◽

Vol 37 (2) ◽

pp. e3

Author(s):

E. Mery ◽

S. Benton ◽

G. Smith ◽

D. Grynspan ◽

S. Bainbridge

Keyword(s):

Cardiovascular Disease ◽

High Risk ◽

Placenta Pathology

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THE ROLE OF PLACENTAL DISORDERS AMONG RISK FACTORS IN THE FORMATION OF ISOLATED HYPOSPADIAS

Russian Journal of Pediatric Surgery ◽

10.18821/1560-9510-2018-22-6-288-291 ◽

2018 ◽

Vol 22 (6) ◽

pp. 288-291

Author(s):

V. V. Nikolaev ◽

Yury N. Solontsov ◽

A. A. Protasov

Keyword(s):

Risk Factors ◽

First Trimester ◽

Reproductive Organs ◽

Premature Births ◽

The Family ◽

Male Line ◽

First Trimester Of Pregnancy ◽

Placenta Pathology ◽

Retrospective Questionnaire

Aim of the study. The incidence of hypospadias increased by 2-3 times within the last 50 years. Changes in the frequency occurred mostly due to the gain of the distal isolated forms. The etiology of the majority of cases of the isolated hypospadias isn’t clear. The study of the origin hypospadias is at a stage of the search and assessment of the value of risk factors. The multifactorial pathology is supposed to be caused by changes in an organism of the mother, a placenta and environment factors. Our research is devoted to the assessment of placental factors in the formation of hypospadias. Material and Methods. We have performed a retrospective questionnaire among parents of 99 children with the isolated forms of hypospadias. The special attention was paid to the collecting of the family anamnesis, including data on diseases of reproductive organs, both at parents and at the immediate family in the male line and also data on a occupation, addictions (smoking) of parents. Information was also collected about the peculiarities of the course of the prenatal period and the outcome of childbirth. On the basis of the obtained data, an assessment of the influence of various “parental” factors on the formation of the isolated hypospadias forms in their sons is given. Results. In 4 out of 99 cases, the origin of isolated hypospadias has been caused by genetic deviations. Primary diseases of reproductive organs in parents have been noted as follow: in fathers in 18 of 95 cases, and in mothers in 12 cases. Most often the placenta pathology in the first trimester of pregnancy was shown by the threat of a spontaneous miscarriage (in 35 cases from 95). Placental disturbances during all pregnancy were accompanied by premature births in 25 cases. In 22 cases placental disorders were shown by a fetus arrest of development. Conclusions. In our research placental disturbances were the most frequent risk factors in the formation of the isolated hypospadias.

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Impact of standardized review of placenta pathology

Placenta ◽

10.1016/j.placenta.2019.06.061 ◽

2019 ◽

Vol 83 ◽

pp. e17-e18

Author(s):

Parastou Tizro ◽

Julia Jiaqi O'Reilly ◽

Anna Penn ◽

Stephanie Barak

Keyword(s):

Placenta Pathology

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P13.09: Which uteroplacental Doppler compartment is related to a worse neonatal outcome and placenta pathology?

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.21005 ◽

2019 ◽

Vol 54 (S1) ◽

pp. 197-197

Author(s):

V. Schiffer ◽

L. Reijerse ◽

C. Severens‐Rijvers ◽

S. Al Nasiry

Keyword(s):

Neonatal Outcome ◽

Placenta Pathology

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Recurrent Intrauterine Growth Restriction (rIUGR): is the placenta pathology the key to the conundrum?

Placenta ◽

10.1016/j.placenta.2017.07.332 ◽

2017 ◽

Vol 57 ◽

pp. 330-331

Author(s):

Keren Rotshenker-Olshinka ◽

Sveta Terlezky ◽

Letizia Shreiber ◽

Rivka Farkash ◽

Arnon Samueloff ◽

...

Keyword(s):

Intrauterine Growth Restriction ◽

Growth Restriction ◽

Intrauterine Growth ◽

Placenta Pathology

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Pregnancy and myeloproliferative neoplasms : A retrospective monocentric cohort

Obstetric Medicine ◽

10.1177/1753495x17708896 ◽

2017 ◽

Vol 10 (4) ◽

pp. 165-169 ◽

Cited By ~ 4

Author(s):

Mathieu Puyade ◽

Emilie Cayssials ◽

Fabrice Pierre ◽

Olivier Pourrat

Keyword(s):

Essential Thrombocythemia ◽

Gestational Age ◽

Small For Gestational Age ◽

Fetal Death ◽

Myeloproliferative Neoplasms ◽

Myelogenous Leukemia ◽

Intrauterine Fetal Death ◽

Recurrent Miscarriages ◽

Fetal Complications ◽

Placenta Pathology

Background The most frequent myeloproliferative neoplasms are essential thrombocythemia and chronic myelogenous leukemia, which usually manifests with thrombocytosis. Only essential thrombocythemia is associated with morbidity during pregnancy (recurrent miscarriages, intrauterine fetal death, small for gestational age and preeclampsia). The aim of this paper is to describe outcomes of pregnancy in women with myeloproliferative neoplasms seen at a single academic institution. Methods Data were collected retrospectively from 2002 to 2015. Descriptive analyses were performed. Results Eighteen pregnancies in 13 patients and 17 births were identified. One patient had recurrent miscarriages. There were two intrauterine fetal deaths, three small for gestational age linked to vascular placenta pathology and one preeclampsia. All of these mothers harbored JAK2V617F mutation. Two out of three patients with small for gestational age developed a venous thrombosis in the two years following delivery. Conclusion Thrombocytosis associated with myeloproliferative neoplasms should be considered as a risk factor for maternal and fetal complications.

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