Association Between Nuclear Receptor Coactivator 1 and Stem Cell Signaling Pathway and Identification of Natural NCOA1 Inhibitors: An in-silico Study

2019 ◽  
pp. 545-564
Author(s):  
Pushpendra Singh ◽  
Prem P. Kushwaha ◽  
Atul K. Singh ◽  
Shashank Kumar
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathway ◽  
Nuclear Receptor ◽  
In Silico ◽  
Nuclear Receptor Coactivator ◽  
Cell Signaling Pathway ◽  
In Silico Study

scholarly journals New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation

2019 ◽  
Vol 234 (12) ◽  
pp. 21642-21661 ◽  
Author(s):  
Marjan Aghajani ◽  
Behzad Mansoori ◽  
Ali Mohammadi ◽  
Zahra Asadzadeh ◽  
Behzad Baradaran
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathway ◽  
Mirna Regulation ◽  
Cell Signaling Pathway

scholarly journals Mesenchymal Stem Cell Signaling Pathway and Interaction Factors

Experimed ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 120-129
Author(s):  
Gulsemin Cicek ◽  
◽  
Selcuk Duman ◽  
Tahsin Murad Aktan ◽  
◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathway ◽  
Cell Signaling Pathway ◽  
Interaction Factors

scholarly journals CLV3 Is Localized to the Extracellular Space, Where It Activates the Arabidopsis CLAVATA Stem Cell Signaling Pathway

2002 ◽  
Vol 14 (5) ◽  
pp. 969-977 ◽  
Author(s):  
Enrique Rojo ◽  
Vijay K. Sharma ◽  
Valentina Kovaleva ◽  
Natasha V. Raikhel ◽  
Jennifer C. Fletcher
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathway ◽  
Extracellular Space ◽  
Cell Signaling Pathway

scholarly journals Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis

2021 ◽  
Vol 118 (8) ◽  
pp. e2021864118
Author(s):  
Mi Cheong Cheong ◽  
Zhu Wang ◽  
Tegegn G. Jaleta ◽  
Xinshe Li ◽  
James B. Lok ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Nuclear Receptor ◽  
Transcriptional Activity ◽  
Strongyloides Stercoralis ◽  
Parasite Development ◽  
Binding Motif ◽  
Nuclear Receptor Coactivator ◽  
Interacting Protein ◽  
Third Stage ◽  
Infectious Stage

DAF-12 is nematode-specific nuclear receptor that has been proposed to govern development of the infectious stage of parasitic species, including Strongyloides stercoralis. Here, we identified a parasite-specific coactivator, called DAF-12 interacting protein-1 (DIP-1), that is required for DAF-12 ligand-dependent transcriptional activity. DIP-1 is found only in Strongyloides spp. and selectively interacts with DAF-12 through an atypical receptor binding motif. Using CRISPR/Cas9-directed mutagenesis, we demonstrate that DAF-12 is required for the requisite developmental arrest and the ligand-dependent reactivation of infectious S. stercoralis infective third-stage larvae, and that these effects require the DIP-1 coactivator. These studies reveal the existence of a distinct nuclear receptor/coactivator signaling pathway that governs parasite development.

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