Cancer Cells Survive Chemoradiotherapy Through Upregulation of a Stem Cell Signaling Pathway, Sonic Hedgehog, and Render Multi-Drug Resistance

2007 ◽  
Vol 69 (3) ◽  
pp. S41
Author(s):  
J. Sims-Mourtada ◽  
J. Izzo ◽  
J. Ajani ◽  
K. Chao
Keyword(s):  
Drug Resistance ◽  
Stem Cell ◽  
Cell Signaling ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Multi Drug Resistance ◽  
Cell Signaling Pathway

scholarly journals Aniridia-related Keratopathy Relevant Cell Signaling Pathways in Human Fetal Corneas

2021 ◽  
Author(s):  
Marta Sloniecka ◽  
Andre Vicente ◽  
Berit Bystrom ◽  
Jingxia Liu ◽  
Fatima Pedrosa-Domellof
Keyword(s):  
Gene Expression ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Cell Signaling Pathway ◽  
Human Adult ◽  
Pathway Activation ◽  
Normal Human ◽  
Cell Signaling Pathways

Background: To study aniridia-related keratopathy (ARK) relevant cell signaling pathways (Notch1, Wnt/β-catenin, Sonic hedgehog (SHH) and mTOR) in normal human fetal corneas in comparison with normal human adult corneas. Results: 20 wg fetal and normal adult corneas showed similar staining patterns for Notch1, however 10-11 wg fetal corneas showed increased presence of Notch1. Numb and Dlk1 had an enhanced presence in the fetal corneas compared to the adult corneas. Fetal corneas showed stronger immunolabeling with antibodies against β-catenin, Wnt5a and Wnt7a, Gli1, Hes1, p-rpS6, and mTOR when compared to the adult corneas. Gene expression of Notch1, Wnt5A, Wnt7A, β-catenin, Hes1, mTOR and rps6 was higher in the 9-12 wg fetal corneas when compared to adult corneas. Conclusions: The cell signaling pathway differences found between human fetal and adult corneas were similar to those previously found in ARK corneas with the exception of Notch1. Analogous profiles of cell signaling pathway activation between human fetal corneas and ARK corneas suggests that there is a less differentiated host milieu in ARK.

scholarly journals New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation

2019 ◽  
Vol 234 (12) ◽  
pp. 21642-21661 ◽  
Author(s):  
Marjan Aghajani ◽  
Behzad Mansoori ◽  
Ali Mohammadi ◽  
Zahra Asadzadeh ◽  
Behzad Baradaran
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Signaling ◽  
Signaling Pathway ◽  
Mirna Regulation ◽  
Cell Signaling Pathway
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