Immune Response and Oxidative Stress in Obesity-Induced Cancer

2021 ◽  
pp. 109-128
Author(s):  
Pradip Kumar Jaiswara ◽  
Pratishtha Sonker ◽  
Ajay Kumar
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
And Oxidative Stress

scholarly journals Effects of pyrene exposure on immune response and oxidative stress in the pearl oyster, Pinctada martensii

2017 ◽  
Vol 63 ◽  
pp. 237-244 ◽  
Author(s):  
Jia Xie ◽  
Chunfeng Zhao ◽  
Qian Han ◽  
Hailong Zhou ◽  
Qingxiao Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Pearl Oyster ◽  
Pinctada Martensii ◽  
And Oxidative Stress

scholarly journals Biochemical and immunological investigation of fascioliasis in cattle in Egypt

2020 ◽  
Vol 13 (5) ◽  
pp. 923-930
Author(s):  
Nani Nasreldin ◽  
Rania Samir Zaki
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Meat Quality ◽  
Stress Factors ◽  
Postmortem Changes ◽  
Immunological Parameters ◽  
Serum Biochemical ◽  
Fasciola Spp ◽  
Glutamyl Transferase ◽  
And Oxidative Stress

Background and Aim: Fasciola hepatica and Fasciola gigantica are two commonly reported liver flukes that cause fascioliasis in ruminants. Among the members of the genus Fasciola, F. hepatica was identified in the study area. Fascioliasis is a major disease that affects the production of livestock by causing liver damage. F. hepatica has developed advanced mechanisms to trick, elude, and alter the host immune response, similar to an extrinsic stressor. These mechanisms consequently affect the animals' physiological and metabolic functions in vivo and postmortem changes, which have significant influences on animal welfare and meat quality development. Therefore, this study aimed to determine the current prevalence of cattle fascioliasis at abattoirs in El-Kharga city, New Valley Governorate, Egypt, and to investigate the changes in serum biochemical and immunological parameters and oxidative stress factors due to Fasciola spp. infection in terms of meat quality and immune response. Materials and Methods: A total of 226 cattle were inspected for the presence of Fasciola spp. The liver of each cattle was examined by making several incisions for detecting adult Fasciola spp. in El- Kharga . The blood samples were collected to analyze the changes in serum biochemical and immunological parameters and oxidative stress factors. Results: Of the 226 cattle, 38 (16.81%) were positive for F. hepatica at the postmortem examination. Cattle infected with F. hepatica had highly elevated serum alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase, γ-glutamyl transferase, urea, and creatinine levels. Immunological cytokine profiles showed significantly increased serum interleukin (IL)-4, IL-10, and transforming growth factor-beta levels and a significantly decreased interferon-γ level. Furthermore, oxidative stress profiles showed significantly increased serum malondialdehyde and nitric oxide levels and significantly decreased total antioxidant capacity and reduced glutathione level. Conclusion: This study demonstrated that F. hepatica infection alone is an oxidative stress factor that affects slaughtered animals, leading to biochemical and metabolic alterations in the early postmortem period.

Avian model to mitigate gut-derived immune response and oxidative stress during heat

Biosystems ◽  
2019 ◽  
Vol 178 ◽  
pp. 10-15 ◽  
Author(s):  
A. Slawinska ◽  
S. Mendes ◽  
A. Dunislawska ◽  
M. Siwek ◽  
M. Zampiga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
And Oxidative Stress

scholarly journals Immunomodulation and Oxidative Stress in Denim Sandblasting Workers: Changes Caused by Silica Exposure

2013 ◽  
Vol 64 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Saziye Sezin Palabiyik ◽  
Gözde Girgin ◽  
Engin Tutkun ◽  
Ömer Hinc Yilmaz ◽  
Terken Baydar
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Cellular Immune Response ◽  
Antioxidant Defense System ◽  
Sod Activity ◽  
Indoleamine 2 ◽  
Silica Exposure ◽  
Tryptophan Degradation ◽  
Cellular Immune ◽  
And Oxidative Stress

Abstract Workers in denim sandblasting are at a high risk of developing silicosis, an occupational lung disease caused by inhaling crystalline silica dust. The development and progress of silicosis is associated with the activation of the immune system and oxidative stress. In the former, interferon-gamma induces both neopterin release and the enzyme indoleamine [2, 3]-dioxygenase (IDO) in various cells. The determination of the kynurenine-to-tryptophan ratio and neopterin concentration has proven to be an efficient method to monitor the activation status of IDO and cellular immunity. The present study aimed to investigate whether occupational silica exposure leads to any alterations in neopterin levels, tryptophan degradation, and activities of superoxide dismutase (SOD) and catalase (CAT), agents in the antioxidant defense system. Fifty-five male denim sandblasting workers and twenty-two healthy men as controls were included. Mean neopterin and kynurenine levels, kynurenine-to-tryptophan ratio, and SOD activity were higher in subjects with silicosis compared to non-exposed controls (all, p<0.05). Neopterin levels and kynurenine-totryptophan ratios were positively correlated (p<0.05); however, no correlation was observed between length of employment and the measured parameters. Some of the measured parameters were significantly affected by the severity of the pathology. Our results suggest that silica exposure activates the cellular immune response. The increased neopterin levels and tryptophan degradation confirm the possibility of their use as an indicator of cellular immune response.

scholarly journals The effects of some microelements supplementation - selenium, zinc and copper into dairy cows feeds on their health and reproductive performances

2016 ◽  
Vol 32 (2) ◽  
pp. 101-110 ◽  
Author(s):  
Mirjana Joksimovic-Todorovic ◽  
Vesna Davidovic ◽  
Mirjana Bojanic-Rasovic
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Dairy Cows ◽  
Health State ◽  
Improve Quality ◽  
Biological Availability ◽  
Quality Of Products ◽  
Positive Effect ◽  
And Oxidative Stress

Microelements such as selenium, zinc and copper are indispensable nutrients for preserving major physiological functions, improving reproductive characteristics and overall health state. By their adequate use different ailments are prevented, while at the same time they have a positive effect on fertility and resistance. Insufficient quantities of these microelements, inadequate absorption and interaction with other microelements may lead to the impairment of the immune response due to metabolic and oxidative stress. In recent years, mainly organic forms of microelements have been administered to animals because they show better biological availability and can be retained longer in the organism. Besides, organic forms improve quality of products for human nutrition. Antioxidants should be added in optimal quantities in food for dairy cows with the aim of maximizing immune function and protection of tissues.

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