One area of organometallic chemistry that has attracted great interest in recent
years is the syntheses, characterization and study of organometallic complexes conjugated
to biomolecules with different steric and electronic properties as potential therapeutic
agents against cancer and malaria, as antibiotics and as radiopharmaceuticals. This minireview
focuses on the unique structural diversity that has recently been discovered in α-
amino acids and the reactions of metallocene complexes with peptides having different
chemical behavior and potential medical applications. Replacing α-amino acids with metallocene
fragments is an effective way of selectively influencing the physicochemical,
structural, electrochemical and biological properties of the peptides. Consequently, research
in the field of bioorganometallic chemistry offers the opportunity to develop bioactive
metal compounds as an innovative and promising approach in the search for pharmacological control of
different diseases.
Optimized pharmacological control over the AAV-Gene-Switch vector for regulable gene therapy
