scholarly journals Holotomography: Refractive Index as an Intrinsic Imaging Contrast for 3-D Label-Free Live Cell Imaging

Author(s):  
Doyeon Kim ◽  
Sangyun Lee ◽  
Moosung Lee ◽  
Juntaek Oh ◽  
Su-A Yang ◽  
...  
2017 ◽  
Author(s):  
Doyeon Kim ◽  
SangYun Lee ◽  
Moosung Lee ◽  
JunTaek Oh ◽  
Su-A Yang ◽  
...  

AbstractLive cell imaging provides essential information in the investigation of cell biology and related pathophysiology. Refractive index (RI) can serve as intrinsic optical imaging contrast for 3-D label-free and quantitative live cell imaging, and provide invaluable information to understand various dynamics of cells and tissues for the study of numerous fields. Recently significant advances have been made in imaging methods and analysis approaches utilizing RI, which are now being transferred to biological and medical research fields, providing novel approaches to investigate the pathophysiology of cells. To provide insight how RI can be used as an imaging contrast for imaging of biological specimens, here we provide the basic principle of RI-based imaging techniques and summarize recent progress on applications, ranging from microbiology, hematology, infectious diseases, hematology, and histopathology.


2012 ◽  
Vol 102 (2) ◽  
pp. 360-368 ◽  
Author(s):  
Katharina Klein ◽  
Alexander M. Gigler ◽  
Thomas Aschenbrenner ◽  
Roberto Monetti ◽  
Wolfram Bunk ◽  
...  

2018 ◽  
Vol 9 (10) ◽  
pp. 2690-2697 ◽  
Author(s):  
Jin-Sung Park ◽  
Il-Buem Lee ◽  
Hyeon-Min Moon ◽  
Jong-Hyeon Joo ◽  
Kyoung-Hoon Kim ◽  
...  

Despite recent remarkable advances in microscopic techniques, it still remains very challenging to directly observe the complex structure of cytoplasmic organelles in live cells without a fluorescent label.


Author(s):  
Raji Atchudan ◽  
Thomas Nesakumar Jebakumar Immanuel Edison ◽  
Suguna Perumal ◽  
N. Clament Sagaya Selvam ◽  
Yong Rok Lee

2019 ◽  
Author(s):  
B. Kemper ◽  
A. Bauwens ◽  
D. Bettenworth ◽  
M. Götte ◽  
B. Greve ◽  
...  

2016 ◽  
Vol 12 (1) ◽  
pp. 1600037 ◽  
Author(s):  
Batirtze Prats Mateu ◽  
Eva Harreither ◽  
Markus Schosserer ◽  
Verena Puxbaum ◽  
Elisabeth Gludovacz ◽  
...  

2021 ◽  
Author(s):  
Gillian F. Lovell ◽  
Daniel A. Porto ◽  
Timothy R. Jackson ◽  
Jasmine Trigg ◽  
Nicola Bevan ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56690 ◽  
Author(s):  
Sebastian Weber ◽  
María L. Fernández-Cachón ◽  
Juliana M. Nascimento ◽  
Steffen Knauer ◽  
Barbara Offermann ◽  
...  

2017 ◽  
Author(s):  
C. Seniya ◽  
C. E. Towers ◽  
D. P. Towers

2010 ◽  
Author(s):  
Oleksandra V. Lyulko ◽  
Gerhard Randers-Pehrson ◽  
David J. Brenner

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