Determination of anti-Aspergillus activity of antifungal agents based on the dynamic growth rate of a single hypha

1993 ◽  
Vol 39 (3) ◽  
Author(s):  
Kibong Oh ◽  
Hideaki Matsuoka ◽  
Yasuyuki Nemoto ◽  
Osao Sumita ◽  
Kosuke Takatori ◽  
...  
2021 ◽  
Author(s):  
Lars Witting

I use the North American Breeding Bird Survey (Sauer et al. 2017) to construct 462 population trajectories with about 50 yearly abundance estimates each. Applying AIC model-selection, I find that selection-regulated population dynamics is 25,000 (95%:0.42-1.7e17) times more probable than density-regulated growth. Selection is essential in 94% of the best models explaining 82% of the population dynamics variance across the North American continent. Similar results are obtained for 111, 215, and 420 populations of British birds (BTO 2020), Danish birds (DOF 2020), and birds and mammals in the Global Population Dynamic Database (GPDD 2010). The traditional paradigm---that the population dynamic growth rate is a function of the environment, with maximal per-capita growth at low population densities, and sub-optimal reproduction from famine at carrying capacities with strong competition for limited resources---is not supported. Selection regulation generates a new paradigm where the world is green and individuals are selected to survive and reproduce at optimal levels at population dynamic equilibria with sufficient resources. It is only the acceleration of the population dynamic growth rate, and not the growth rate itself, that is determined by the density-dependent environment, with maximal growth occurring at the densities of the population dynamic equilibrium.


Nano Letters ◽  
2003 ◽  
Vol 3 (6) ◽  
pp. 863-865 ◽  
Author(s):  
Do-Hyung Kim ◽  
Hoon-Sik Jang ◽  
Chang-Duk Kim ◽  
Dong-Soo Cho ◽  
Hee-Sun Yang ◽  
...  

2019 ◽  
Vol 286 ◽  
pp. 169-177
Author(s):  
Kang-In Lee ◽  
Hyun-Taek Lee ◽  
Ki-Hwan Jang ◽  
Sung-Hoon Ahn

2017 ◽  
Vol 50 ◽  
pp. 41-47 ◽  
Author(s):  
Martin Egblewogbe ◽  
Garu Gebreyesus ◽  
Samuel A. Atarah

Powders consisting of nanoparticles of zinc peroxide were prepared via a simple hydrothermal process using zinc acetate dihydrate and hydrogen peroxide precursors. The size of the crystallites was determined using x-ray powder diffraction. Over a period of 5 hours the crystallite radius increased from 4 nm – 9 nm at a temperature of 68 °C ± 5 °C, with growth rate constant of 0.23 nm3 min−1 calculated using the Lifshitz, Slyozov, and Wagner model. The powders were further characterised with High Resolution Transmission Electron Microscopy, Energy Dispersive X-ray analysis, and Small Angle X-ray Scattering, showing well-crystallised ZnO2 nanoparticles.


1998 ◽  
Vol 42 (8) ◽  
pp. 1900-1905 ◽  
Author(s):  
George S. Baillie ◽  
L. Julia Douglas

ABSTRACT A perfused biofilm fermentor, which allows growth-rate control of adherent microbial populations, was used to assess whether the susceptibility of Candida albicans biofilms to antifungal agents is dependent on growth rate. Biofilms were generated under conditions of glucose limitation and were perfused with drugs at a high concentration (20 times the MIC). Amphotericin B produced a greater reduction in the number of daughter cells in biofilm eluates than ketoconazole, fluconazole, or flucytosine. Similar decreases in daughter cell counts were observed when biofilms growing at three different rates were perfused with amphotericin B. In a separate series of experiments, intact biofilms, resuspended biofilm cells, and newly formed daughter cells were removed from the fermentor and were exposed to a lower concentration of amphotericin B for 1 h. The susceptibility profiles over a range of growth rates were then compared with those obtained for planktonic cells grown at the same rates under glucose limitation in a chemostat. Intact biofilms were resistant to amphotericin B at all growth rates tested, whereas planktonic cells were resistant only at low growth rates (≤0.13 h−1). Cells resuspended from biofilms were less resistant than intact biofilm populations but more resistant than daughter cells; the susceptibilities of both these cell types were largely independent of growth rate. Our findings indicate that the amphotericin B resistance of C. albicans biofilms is not simply due to a low growth rate but depends on some other feature of the biofilm mode of growth.


2016 ◽  
pp. 77-98
Author(s):  
Nenad Rankovic ◽  
Jelena Nedeljkovic ◽  
Zoran Poduska ◽  
Dragan Nonic

This study examines the influence of some climate elements on the collected quantities of two commercially most significant types of mushrooms in Serbia (porcini and chanterelle). The main objective of the research is to determine the extent of the collected quantity of porcini and chanterelle, which can be expected in different scenarios of climate change (?1Bmin, ?1Bmax, A2min ? A2max), based on forecasts of temperature and rainfall changes. The general (dialectical) and specific (modelling methods) are used in the research, as well as the classical scientific methods of reasoning. The calculation of the average annual exponential growth rate (IS) was carried out by forming exponential regression models of the trend of porcini and chanterelle collected quantities. In the research it was found that, according to the data related to the period up to 2014, one can expect a decrease in the movement of both porcini and chanterelle IS, and thus a decrease in the collected quantities. On the other hand, according to the data related to the period up to 2040, in both cases one can expect some fluctuation (increase and decrease) in the movement of IS. According to the data related to periods after 2041 (especially for the period until 2100), in both cases, one can expect a decrease in the collected quantities, as a result of changes in T and P, caused by the assumed climate change.


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