scholarly journals Rearrangement, amplification, and assortment of mitochondrial DNA molecules in cultured cells of Brassica campestris

1989 ◽  
Vol 77 (1) ◽  
pp. 17-25 ◽  
Author(s):  
M. Shirzadegan ◽  
M. Christey ◽  
E. D. Earle ◽  
J. D. Palmer
Keyword(s):  
Mitochondrial Dna ◽  
Brassica Campestris ◽  
Cultured Cells ◽  
Dna Molecules

scholarly journals Patterns of mitochondrial DNA instability in Brassica campestris cultured cells

1991 ◽  
Vol 16 (1) ◽  
pp. 21-37 ◽  
Author(s):  
Magid Shirzadegan ◽  
Jeffrey D. Palmer ◽  
Mary Christey ◽  
Elizabeth D. Earle
Keyword(s):  
Mitochondrial Dna ◽  
Brassica Campestris ◽  
Cultured Cells ◽  
Dna Instability ◽  
Mitochondrial Dna Instability

scholarly journals Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

2021 ◽  
Author(s):  
Hans-Georg Sprenger ◽  
Thomas MacVicar ◽  
Amir Bahat ◽  
Kai Uwe Fiedler ◽  
Steffen Hermans ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cultured Cells ◽  
De Novo ◽  
Metabolic Response ◽  
Interferon Response ◽  
Type I ◽  
Nucleotide Synthesis ◽  
Pyrimidine Synthesis ◽  
Pyrimidine Nucleotide ◽  
De Novo Pyrimidine Synthesis

AbstractCytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that mtDNA-dependent immune signalling via the cyclic GMP–AMP synthase‒stimulator of interferon genes‒TANK-binding kinase 1 (cGAS–STING–TBK1) pathway is under metabolic control and is induced by cellular pyrimidine deficiency. The mitochondrial protease YME1L preserves pyrimidine pools by supporting de novo nucleotide synthesis and by proteolysis of the pyrimidine nucleotide carrier SLC25A33. Deficiency of YME1L causes inflammation in mouse retinas and in cultured cells. It drives the release of mtDNA and a cGAS–STING–TBK1-dependent inflammatory response, which requires SLC25A33 and is suppressed upon replenishment of cellular pyrimidine pools. Overexpression of SLC25A33 is sufficient to induce immune signalling by mtDNA. Similarly, depletion of cytosolic nucleotides upon inhibition of de novo pyrimidine synthesis triggers mtDNA-dependent immune responses in wild-type cells. Our results thus identify mtDNA release and innate immune signalling as a metabolic response to cellular pyrimidine deficiencies.

Small mitochondrial DNA molecules of wild abortive cytoplasm in rice are not necessarily associated with CMS

1989 ◽  
Vol 77 (5) ◽  
pp. 617-619 ◽  
Author(s):  
N. M. Saleh ◽  
B. J. Mulligan ◽  
E. C. Cocking ◽  
H. S. Gupta
Keyword(s):  
Mitochondrial Dna ◽  
Dna Molecules ◽  
Wild Abortive Cytoplasm
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