Intra-tissue low-dose and high-dose radiation therapy of soft tissue sarcomas: Approaches to planning and clinical results

1992 ◽  
Vol 26 (6) ◽  
pp. 319-319
Author(s):  
M. A. Sushchikhina ◽  
G. R. Tsikhiseli
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Low Dose ◽  
Soft Tissue Sarcomas ◽  
Clinical Results ◽  
High Dose ◽  
Dose Radiation

Low-Dose Versus High-Dose Radiation Therapy for the Palliation of Dysphagia From Esophageal Cancer: A Multicenter Retrospective Cohort Study

2020 ◽  
Vol 10 (4) ◽  
pp. e255-e263 ◽  
Author(s):  
Bram D. Vermeulen ◽  
Paul M. Jeene ◽  
Jasmijn Sijben ◽  
Robin Krol ◽  
Heidi Rütten ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Low Dose ◽  
High Dose ◽  
Dose Radiation

scholarly journals Trabectedin with concurrent low-dose of radiation therapy for metastatic soft tissue sarcomas: A phase II trial of Spanish, French and Italian sarcoma groups

2019 ◽  
Vol 30 ◽  
pp. v686-v687
Author(s):  
J Martin Broto ◽  
A. Italiano ◽  
R M Alvarez Alvarez ◽  
I. Rincon ◽  
J. Peinado ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Phase Ii ◽  
Low Dose ◽  
Phase Ii Trial ◽  
Soft Tissue Sarcomas

Low Dose Versus High Dose Radiation Therapy for Indolent Primary Cutaneous B-Cell Lymphomas

2015 ◽  
Vol 93 (3) ◽  
pp. E455
Author(s):  
A. Goyal ◽  
J. Carter ◽  
I.M. Pashtan ◽  
S. Gallotto ◽  
A. Niemierko ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
B Cell ◽  
Low Dose ◽  
High Dose ◽  
B Cell Lymphomas ◽  
Dose Radiation

scholarly journals Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments

Dose-Response ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 155932582110561
Author(s):  
Alexandra Jameus ◽  
Allison E. Kennedy ◽  
Christopher Thome
Keyword(s):  
Radiation Therapy ◽  
Low Dose ◽  
Standard Of Care ◽  
Limiting Factors ◽  
High Dose ◽  
Hematologic Toxicity ◽  
Low Dose Radiation ◽  
Current Standard ◽  
Hematological Changes ◽  
Dose Radiation

Cancer is the second leading cause of mortality worldwide accounting for almost 10 million deaths in 2020. Current standard of care treatment varies depending on the type and stage of disease, but commonly includes surgery, chemotherapy, and/or radiation therapy. There is evidence that whole- and half-body exposure to low dose ionizing radiation can also be an effective therapeutic due to its stimulation of anti-cancer immunity. One of the limiting factors for past clinical trials using low dose radiation therapy has been adverse hematological events. However, similar hematological changes are also frequently reported following standard of care treatments in oncology. This review summarizes the effects of various cancer therapies on hematologic toxicity through the evaluation of complete blood count reports. The reviewed literature elucidates hematological trends in patients undergoing chemotherapy, and both high and low dose radiation therapy. In general, high dose radiation and chemotherapy can result in widespread changes in blood counts, with the most severe effects related to leukopenia. Overall, compared to standard of care treatments, low dose radiation results in similar, yet more mild hematological changes. Taken together, hematological toxicities should not be a limiting factor in the applicability of low dose radiation as a cancer therapeutic.

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