Production of antitumor sera by immunizing animals with tumor cells freed from connective tissue stroma

1965 ◽  
Vol 60 (2) ◽  
pp. 942-944
Author(s):  
Ya. A. Umanskii
Author(s):  
E. J. Kollar

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.


2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Ramalingam Suganya ◽  
Narasimhan Malathi ◽  
Subramani Vijaya Nirmala ◽  
Chinnaswami Ravindran ◽  
Harikrishnan Thamizhchelvan

Choristomas are rare entities which are aggregates of microscopically normal cells or tissues in aberrant locations. They are a “heterotopic” rest of cells, as they appear as a tumor-like mass. Herein we report a case of cartilaginous choristoma in a 54-year-old male who presented with a swelling on right lower gingiva. The histopathological examination revealed features of a well circumscribed mass of mature cartilage in a dense fibrous connective tissue stroma.


2002 ◽  
Vol 39 (2) ◽  
pp. 266-268 ◽  
Author(s):  
B. Sanchez ◽  
A. Nieto ◽  
M. A. Ruiz de Leon ◽  
J. Rodríguez ◽  
J. Flores

A lymphangiosarcoma with metastases was found in a horse that presented with respiratory distress and edema in the ventral thorax and abdomen. The necropsy revealed diffuse edema in the subcutaneous connective tissue. Mediastinal, mesenteric, iliac, and renal lymph nodes were enlarged and white with soft, yellowish necrotic areas. Histologic examination revealed numerous channels and disorganized vessels lined by large polyhedral, polymorphic cells. Tumor metastases were observed in the spleen, lungs, and kidneys. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for factor VIII, vimentin, and keratin. Laminin was scarce, and collagen IV staining was negative, consistent with a discontinuous or absent basement membrane.


1968 ◽  
Vol 41 (3) ◽  
pp. 363-371 ◽  
Author(s):  
L. MARTIN ◽  
C. A. FINN

SUMMARY Progesterone treatment significantly altered the response of the mouse uterus to oestradiol-17β. Oestradiol given alone produced many mitoses in the luminal and glandular epithelia but not in the connective tissue stroma. After treatment with progesterone this pattern was reversed and oestradiol produced many mitoses in the stroma but few in the epithelia. Production of stromal cell division was influenced by the dose of progesterone and by the period of treatment; a single day of treatment greatly reduced the numbers of epithelial mitoses produced by oestradiol but did not greatly increase stromal mitosis. At least 3 days' treatment was necessary for a maximal stromal response. Doses of oestradiol sufficient to inhibit implantation and deciduomata production did not reverse the stromal response but did overcome, in part, the progestational suppression of epithelial mitosis, producing large numbers of mitoses in the luminal but not in the glandular epithelium.


2009 ◽  
Vol 8 (1(2)) ◽  
pp. 69-71
Author(s):  
T. N. Slynko ◽  
M. Ya. Velikorodova ◽  
N. N. Zarechnova

Study of the pancreas of the rats at different periods deadaptation to valley, after 60 day adaptations to mountain has revealled significant change, which at the first periods of the study (7, 15 day) were concluded in edema stroma, inflammatory round cells, plethora container and grousing connective tissue between share and around acinus. At late periods of the study dominated change, expressing grousing connective tissue stroma ferrics with atrophy acinus parenchyma and dystrophic change acinous hutches (picnosis, vacuolization of cytoplasm). Deadaption has found the weakening an compensatory reaction with prevalence destruction processes in pancreas.


1975 ◽  
Vol 23 (2) ◽  
pp. 151 ◽  
Author(s):  
CHS Watts

The gross and microscopical anatomy of the neck glands of Notomys alexis, N. mitchellii, N. cervinus and N. fuscus is described. In N. alexis, N. mitchellii and N. fuscus the glandular area was composed of a sheet of sebaceous-type glands supported by a small amount of connective tissue. The gross morphology of the glandular area varied between these three species, being simplest in N. mitchellii and most complex in N. fuscus. N. cervinus had no neck gland, but males had a gland made up of a mass of lobules separately embedded in a connective tissue stroma in the sternal region. In all species the glandular area was active in all adult males, but in females only during pregnancy and lactation. It is considered that territorial marking and marking of group members, including newborn young, are among the most likely uses of the glands.


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