In vivo measurement of tumor blood oxygenation by near-infrared spectroscopy: Immediate effects of pentobarbital overdose or carmustine treatment

1994 ◽  
Vol 22 (3) ◽  
pp. 209-220 ◽  
Author(s):  
R. Grant Steen ◽  
Keiko Kitagishi ◽  
Kenneth Morgan
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Blood Oxygenation ◽  
In Vivo Measurement

Simulation and in vivo investigation of light-emitting diode, near infrared Gaussian beam profiles

2019 ◽  
Vol 28 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Mahya Mirbagheri ◽  
Naser Hakimi ◽  
Elias Ebrahimzadeh ◽  
S Kamaledin Setarehdan
Keyword(s):  
Infrared Spectroscopy ◽  
Penetration Depth ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Light Emitting Diode ◽  
Low Cost ◽  
Blood Oxygenation ◽  
Stress Assessment ◽  
Depth Sensitivity

Near infrared spectroscopy is an optical imaging technique which offers a non-invasive, portable, and low-cost method for continuously measuring the oxygenation of tissues. In particular, it can provide the brain activation through measuring the blood oxygenation and blood volume in the cortex. Understanding and then improving the spatial and depth sensitivity of near infrared spectroscopy measurements to brain tissue are essential for designing experiments as well as interpreting research findings. In this study, we investigate the effect of applying two common light beam profiles including Uniform and Gaussian on the penetration depth of an LED-based near infrared spectroscopy. In this regard, two Gaussian profiles were produced by adjusting plano-convex and bi-convex lenses and the Uniform profile was provided by applying a flat lens. Two experiments were conducted in this study. First, a simulation experiment was carried out based on scanning the intra space of a liquid phantom by using static and pulsating absorbers to compare the penetration depth of the configurations applied on the LED-based near infrared spectroscopy with that of a laser-based near infrared spectroscopy. Second, to show the feasibility of the best proposed configuration applied, an in vivo experiment of stress assessment has been performed and its results have been compared with that results obtained by laser one. The results showed that the LED-based near infrared spectroscopy equipped with bi-convex lens provides a penetration depth and hence quality measurements of near infrared spectroscopy and its extracted heart rate variability signals as well as laser-based near infrared spectroscopy especially in the application of stress assessment.

scholarly journals A Versatile Setup for Time-Resolved Functional Near Infrared Spectroscopy Based on Fast-Gated Single-Photon Avalanche Diode and on Four-Wave Mixing Laser

2019 ◽  
Vol 9 (11) ◽  
pp. 2366 ◽  
Author(s):  
Laura Di Sieno ◽  
Alberto Dalla Mora ◽  
Alessandro Torricelli ◽  
Lorenzo Spinelli ◽  
Rebecca Re ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Single Photon ◽  
Wave Mixing ◽  
Functional Near Infrared Spectroscopy ◽  
Time Resolved ◽  
Diffusive Medium ◽  
Spectroscopy System

In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation.

scholarly journals Functional Near-Infrared Spectroscopy for the Classification of Motor-Related Brain Activity on the Sensor-Level

Sensors ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. 2362 ◽  
Author(s):  
Alexander E. Hramov ◽  
Vadim Grubov ◽  
Artem Badarin ◽  
Vladimir A. Maksimenko ◽  
Alexander N. Pisarchik
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
High Efficiency ◽  
Brain Activity ◽  
Blood Oxygenation ◽  
Hemispheric Lateralization ◽  
Motor Execution ◽  
Functional Near Infrared Spectroscopy

Sensor-level human brain activity is studied during real and imaginary motor execution using functional near-infrared spectroscopy (fNIRS). Blood oxygenation and deoxygenation spatial dynamics exhibit pronounced hemispheric lateralization when performing motor tasks with the left and right hands. This fact allowed us to reveal biomarkers of hemodynamical response of the motor cortex on the motor execution, and use them for designing a sensing method for classification of the type of movement. The recognition accuracy of real movements is close to 100%, while the classification accuracy of imaginary movements is lower but quite high (at the level of 90%). The advantage of the proposed method is its ability to classify real and imaginary movements with sufficiently high efficiency without the need for recalculating parameters. The proposed system can serve as a sensor of motor activity to be used for neurorehabilitation after severe brain injuries, including traumas and strokes.

In vivo detection of reduced scattering coefficient of C6 glioma in rat brain tissue by near-infrared spectroscopy

2008 ◽  
Vol 13 (4) ◽  
pp. 044003 ◽  
Author(s):  
Lijuan Dai ◽  
Zhiyu Qian ◽  
Kuanzheng Li ◽  
Tianming Yang ◽  
Huinan Wang
Keyword(s):  
Infrared Spectroscopy ◽  
Rat Brain ◽  
Brain Tissue ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
C6 Glioma ◽  
Scattering Coefficient ◽  
In Vivo Detection ◽  
Rat Brain Tissue
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