Characteristic motor activity of the gastrointestinal tract in fasted conscious dogs measured by implanted force transducers

1978 ◽  
Vol 23 (3) ◽  
pp. 229-238 ◽  
Author(s):  
Zen Itoh ◽  
Shinjin Takeuchi ◽  
Isamu Aizawa ◽  
Ryuichi Takayanagi
Keyword(s):  
Gastrointestinal Tract ◽  
Motor Activity ◽  
Conscious Dogs ◽  
Force Transducers ◽  
Characteristic Motor

Interdigestive motor activity of Heidenhain pouches in relation to main stomach in conscious dogs.

1978 ◽  
Vol 234 (3) ◽  
pp. E333
Author(s):  
Z Itoh ◽  
R Takayanagi ◽  
S Takeuchi ◽  
S Isshiki
Keyword(s):  
Nervous System ◽  
Motor Activity ◽  
Parasympathetic Nervous System ◽  
Contractile Activity ◽  
Secretory Activity ◽  
Conscious Dogs ◽  
Heidenhain Pouch ◽  
Long Period ◽  
Force Transducers

A great number of studies using Heidenhain pouches have been reported, but most of them have been concerned with secretory activity. Studies on the motor activity of the pouch are few, and our knowledge about it is rather limited. In the present study, therefore, long-term changes in contractile activity of the Heidenhain pouches were recorded simultaneously with those of the main stomach in conscious dogs by means of chronically implanted force transducers. It was found that during the interdigestive state Heidenhain pouches contracted precisely in association with the main stomach. During this time a series of strong contractions arose simultaneously in the Heidenhain pouch and the main stomach, lasted for 24.2 +/- 1.90 min, and then ceased abruptly. Such strong contractions were followed by a long period of motor quiescence lasting for 86.9 +/- 6.06 min. These characteristic recurring episodes in the Heidenhain pouch and the main stomach lasted during the interdigestive state but were inhibited by the ingestion of food or intravenous administration of pentagastrin. These findings indicate that the interdigestive motor activity of the stomach is strongly controlled by a humoral factor(s) rather than the parasympathetic nervous system; however, we also propose a possible role for the sympathetic nervous system for coordinated occurrence of the interdigestive contractions between the Heidenhain pouch and the main stomach.

scholarly journals Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs.

1995 ◽  
Vol 176 (1) ◽  
pp. 53-60 ◽  
Author(s):  
CHIKASHI SHIBATA ◽  
IWAO SASAKI ◽  
HIROO NAITO ◽  
MICHINAGA TAKAHASHI ◽  
TAKASHI DOI ◽  
...  
Keyword(s):  
Motor Activity ◽  
Conscious Dogs ◽  
Colonic Motor ◽  
Colonic Motor Activity

Effect of vagotomy on the acid response to gastric distension

1970 ◽  
Vol 48 (10) ◽  
pp. 670-674 ◽  
Author(s):  
R. M. Preshaw
Keyword(s):  
Motor Activity ◽  
Gastric Acid ◽  
Motor Response ◽  
Acid Output ◽  
The Body ◽  
Conscious Dogs ◽  
Truncal Vagotomy ◽  
Gastric Distension ◽  
Gastric Acid Output

Distension of the body of the stomach, in conscious dogs with vagally innervated antral pouches, caused an increase in gastric acid output, and an increase in antral motor activity. Truncal vagotomy inhibited the acid response to distension, but had no effect on the antral motor response. Denervation of the antral pouch by separating it from the main stomach caused little further diminution in the response.

Intragastric monosodium l-glutamate stimulates motility of upper gut via vagus nerve in conscious dogs

2010 ◽  
Vol 298 (4) ◽  
pp. R1125-R1135 ◽  
Author(s):  
Yoshitaka Toyomasu ◽  
Erito Mochiki ◽  
Mitsuhiro Yanai ◽  
Kyoichi Ogata ◽  
Yuichi Tabe ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Vagus Nerve ◽  
Contractile Response ◽  
Conscious Dogs ◽  
Gut Motility ◽  
Umami Taste ◽  
Force Transducers ◽  
Postprandial Motility ◽  
Gastric Corpus ◽  
Pavlov Pouch

Monosodium l-glutamate (MSG) is a substance known to produce the umami taste. Recent studies indicate that MSG also stimulates a variety of activities in the gastrointestinal tract through its receptor in the gut, but no study has reported the activity in conscious large experimental animals. The aim of our study was to investigate whether direct intragastric MSG stimulates gut motility and to identify the mechanism in conscious dogs. Contractile response to intraluminal injection of MSG was studied in the fed and fasted states by means of chronically implanted force transducers. MSG (5, 15, 45, and 90 mM/kg) dissolved in water was injected into the stomach and duodenum in normal and vagotomized dogs. MSG solution was administered into the stomach before feeding, and gastric emptying was evaluated. Several inhibitors of gastrointestinal motility (atropine, hexamethonium, and granisetron) were injected intravenously before MSG administration to the stomach. The effect of MSG was investigated in Pavlov (vagally innervated corpus pouch), Heidenhain (vagally denervated corpus pouch), and antral pouch (vagally innervated) dogs. Upper gut motility was significantly increased by intragastric MSG but not significantly stimulated by intraduodenal MSG. Intragastric MSG (45 mM/kg) stimulated postprandial motility and accelerated gastric emptying. MSG-induced contractions were inhibited by truncal vagotomy, atropine, hexamethonium, and granisetron. Gut motility was increased by intrapouch injection of MSG in the Pavlov pouch, but it was not affected in the Heidenhain or antral pouch dogs. We conclude that intragastric MSG stimulates upper gut motility and accelerates gastric emptying. The sensory structure of MSG is present in the gastric corpus, and the signal is mediated by the vagus nerve.

Pyloric contribution to antroduodenal resistance to flow in the conscious dog

1987 ◽  
Vol 253 (1) ◽  
pp. G72-G78 ◽  
Author(s):  
F. Mearin ◽  
F. Azpiroz ◽  
J. R. Malagelada
Keyword(s):  
Motor Activity ◽  
Phase I ◽  
Conscious Dogs ◽  
Phase Iii ◽  
Control Group ◽  
Conscious Dog ◽  
Motor Cycle ◽  
Interdigestive Motility ◽  
Specific Contribution

We have developed a pneumatic resistometer to monitor antroduodenal resistance to flow for prolonged periods of time in conscious dogs. To investigate the specific contribution of the pylorus to antroduodenal resistance we compared resistance during fasting in four control dogs and in four dogs with extramucosal pyloric myotomy (1.5 cm long). After pyloric myotomy, as in controls, resistance to flow changed cyclically, being lowest during phase I and highest during phase III of the interdigestive motor cycle. Pyloric myotomy decreased resistance during phase III. Atropine (0.1 mg X kg-1 X h-1) administered during motor quiescence (phase I) reduced resistance in the control group (P less than 0.05) but not in myotomized animals. Bethanechol(0.2 mg X kg-1 X h-1) significantly increased resistance in both groups (P less than 0.05). We conclude that antroduodenal resistance to flow is related to cyclic interdigestive motility. The pylorus is the predominant determinant of antroduodenal resistance during motor quiescence, but its contribution diminishes markedly during motor activity.

scholarly journals Effect of JCM 102, a novel bisacodyl enteric seamless soft capsule, on colonic motor activity in conscious dogs

1998 ◽  
Vol 76 ◽  
pp. 292
Author(s):  
Kyoji Chaki ◽  
Shoichi Inui ◽  
Takeshi Ishii ◽  
Hidetsugu Ishida ◽  
Nobuyasu Chatani ◽  
...  
Keyword(s):  
Motor Activity ◽  
Conscious Dogs ◽  
Colonic Motor ◽  
Colonic Motor Activity

Interdigestive contractile patterns of the ileum in dogs

1987 ◽  
Vol 253 (4) ◽  
pp. G452-G460 ◽  
Author(s):  
M. L. Siegle ◽  
H. J. Ehrlein
Keyword(s):  
Strain Gauge ◽  
Propagation Velocity ◽  
Conscious Dogs ◽  
Phase Iii ◽  
Computerized Analysis ◽  
Force Transducers ◽  
Sequential Movement ◽  
Complex Patterns

The aim of this study is to elucidate the nature of ileal interdigestive contractile patterns by the computerized analysis of the contraction spread and by videofluoroscopy. Conscious dogs equipped with closely spaced strain-gauge force transducers were used. Two patterns of repetitive, phasic contractions were recorded, migrating clusters and phase IIIs; both patterns consisted of repetitive, propagated contractions. Both patterns migrated aborad by sequential movement of contraction waves down the bowel. Consequently, the rate of migration of either of the entire patterns was slower than the propagation velocity of constituent, individual contraction waves. Both patterns differed in several parameters, especially the propagated contractions of the clusters spread over shorter distances (1.47 +/- 0.4 cm) than those of phase III (4.65 +/- 0.99 cm). Compared with these complex patterns, propagating power contractions represented single contractions that propagated aborad at the same velocity as the contraction waves of the complex patterns. All three patterns propelled luminal contents distally.

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