Selenium deficiency and fulvic acid supplementation induces fibrosis of cartilage and disturbs subchondral ossification in knee joints of mice: An animal model study of Kashin-Beck disease

1993 ◽  
Vol 423 (6) ◽  
pp. 483-491 ◽  
Author(s):  
Chunlin Yang ◽  
Eduard Wolf ◽  
Kerstin Röser ◽  
Günter Delling ◽  
Peter K. Müller
Keyword(s):  
Animal Model ◽  
Fulvic Acid ◽  
Selenium Deficiency ◽  
Knee Joints ◽  
Acid Supplementation ◽  
Model Study ◽  
Animal Model Study ◽  
Beck Disease

scholarly journals Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue. An animal model to study the molecular defects of Kashin-Beck disease

1993 ◽  
Vol 289 (3) ◽  
pp. 829-835 ◽  
Author(s):  
C Yang ◽  
C Niu ◽  
M Bodo ◽  
E Gabriel ◽  
H Notbohm ◽  
...  
Keyword(s):  
Animal Model ◽  
Fulvic Acid ◽  
Structural Integrity ◽  
Selenium Deficiency ◽  
Collagen I ◽  
Bone Collagen ◽  
Deficient Diet ◽  
Skeletal Tissue ◽  
Collagen Ii ◽  
Beck Disease

High concentrations of fulvic acid and selenium deficiency are the main causative factors of Kashin-Beck disease, an endemic, chronic and degenerative osteoarticular disorder found in China. In the search for an animal model of this disease, mice were exposed to these pathogenetic conditions for two generations and the collagen types from skin, bone and cartilage were analysed. The growth of the treated mice was slightly retarded, and the rate of reproduction was lower in animals maintained on a fulvic acid-supplemented and/or selenium-deficient diet. Irregular bone formation was seen by radiography and morphometry. Biochemical analysis indicated that lysine residues in collagen I from bone and in collagen II from cartilage were overmodified. The values of Hyl/(Hyl+Lys) in bone collagen alpha 1(I) chains from treated mice were about 0.434-0.484, i.e. substantially higher than that of the control (0.277). The values of this parameter for collagen II were 0.482 for control and 0.546-0.566 for treated mice. The melting temperature of collagen I from bones of treated mice was 1 degrees C lower than that of control collagen, indicating decreased thermal stability. The breakage point of the tibiae of treated mice occurred at a lower preload force than for controls, suggesting that the overmodified and thermally less stable collagen molecules are causally related to a lower mechanical strength of bones.

Recent advances in animal model experimentation in autism research

2013 ◽  
Vol 26 (5) ◽  
pp. 264-271 ◽  
Author(s):  
Mousumi Tania ◽  
Md. Asaduzzaman Khan ◽  
Kun Xia
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Human Condition ◽  
Behavioral Alterations ◽  
Important Place ◽  
Adult Mice ◽  
Recent Advances ◽  
Model Study ◽  
Disease Biology ◽  
Animal Model Study

ObjectiveAutism, a lifelong neuro-developmental disorder is a uniquely human condition. Animal models are not the perfect tools for the full understanding of human development and behavior, but they can be an important place to start. This review focused on the recent updates of animal model research in autism.MethodsWe have reviewed the publications over the last three decades, which are related to animal model study in autism.ResultsAnimal models are important because they allow researchers to study the underlying neurobiology in a way that is not possible in humans. Improving the availability of better animal models will help the field to increase the development of medicines that can relieve disabling symptoms. Results from the therapeutic approaches are encouraging remarkably, since some behavioral alterations could be reversed even when treatment was performed on adult mice. Finding an animal model system with similar behavioral tendencies as humans is thus vital for understanding the brain mechanisms, supporting social motivation and attention, and the manner in which these mechanisms break down in autism. The ongoing studies should therefore increase the understanding of the biological alterations associated with autism as well as the development of knowledge-based treatments therapy for those struggling with autism.ConclusionIn this review, we have presented recent advances in research based on animal models of autism, raising hope for understanding the disease biology for potential therapeutic intervention to improve the quality of life of autism individuals.

Mangosteen Can Improve Steatohepatitis through Modulating Inflammatory and Autophagy/Apoptosis Cell Injury: An Animal Model Study

2021 ◽  
Vol 55 (5) ◽  
pp. 480-490
Author(s):  
S. M. Mohamed ◽  
D. S. Mohammed ◽  
N. G. Abd Elhaliem ◽  
M. I. Elbadry ◽  
E. E. Abu-Dief
Keyword(s):  
Animal Model ◽  
Cell Injury ◽  
Model Study ◽  
Animal Model Study

Activators of SIRT1 in wound repair: an animal model study

2019 ◽  
Vol 311 (3) ◽  
pp. 193-201 ◽  
Author(s):  
Ana Cristina Christovam ◽  
Viviane Theodoro ◽  
Fernanda Aparecida Sampaio Mendonça ◽  
Marcelo Augusto Marretto Esquisatto ◽  
Gláucia Maria Tech dos Santos ◽  
...  
Keyword(s):  
Animal Model ◽  
Wound Repair ◽  
Model Study ◽  
Animal Model Study

scholarly journals Endoscopic detachable auxiliary manipulator in endoscopic submucosal dissection: Animal model studY

2018 ◽  
Vol 29 ◽  
pp. v36
Author(s):  
H. Jeon ◽  
H. Chun ◽  
B. Keum ◽  
J. Lee ◽  
S. Choi ◽  
...  
Keyword(s):  
Animal Model ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Model Study ◽  
Animal Model Study

scholarly journals Systemic administration of curcumin nanoparticles protects ischemia-reperfusion injury in ovaries: An animal model study

2018 ◽  
Vol 64 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Tahereh Behroozi-Lak ◽  
Malahat Ebrahimpour ◽  
Leila Zarei ◽  
Masoumeh Pourjabali ◽  
Negin Farhad ◽  
...  
Keyword(s):  
Animal Model ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Systemic Administration ◽  
Curcumin Nanoparticles ◽  
Model Study ◽  
Animal Model Study
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