Age-dependent expression of osteoblastic phenotypic markers in normal human osteoblasts cultured long term in the presence of dexamethasone

In order to determine possible trends in the dynamics and characterological structure of personality in the General population caused by the COVID-19 pandemic, which is a long-term strong stressful effect and clinically and psychopathologically comparable to chronic personality changes after experiencing a disaster, the conditions predisposing to personal transformation, including clinical and prognostic patterns, are analyzed. The age-dependent nature of these changes is shown, and a number of features identified for different age groups are discussed.

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Specialized systems for the processing of mnemonic information within the primate frontal cortex

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.1996.0130 ◽

1996 ◽

Vol 351 (1346) ◽

pp. 1455-1462 ◽

Cited By ~ 229

Keyword(s):

Frontal Cortex ◽

Specific Activity ◽

Human Subjects ◽

Long Term Memory ◽

Executive Processing ◽

Severe Impairment ◽

Normal Human ◽

Short And Long Term ◽

Cortical Association Areas

The lateral frontal cortex is involved in various aspects of executive processing within short- and long-term memory. It is argued that the different parts of the lateral frontal cortex make distinct contributions to memory that differ in terms of the level of executive processing that is carried out in interaction with posterior cortical systems. According to this hypothesis, the mid-dorsolateral frontal cortex (areas 46 and 9) is a specialized system for the monitoring and manipulation of information within working memory, whereas the mid-ventrolateral frontal cortex (areas 47/12 and 45) is involved in the active retrieval of information from the posterior cortical association areas. Data are presented which support this two-level hypothesis that posits two distinct levels of interaction of the lateral frontal cortex with posterior cortical association areas. Functional activation studies with normal human subjects have demonstrated specific activity within the mid-dorsolateral region of the frontal cortex during the performance of tasks requiring monitoring of self-generated and externally generated sequences of responses. In the monkey, lesions restricted to this region of the frontal cortex yield a severe impairment in performance of the above tasks, this impairment appearing against a background of normal performance on several basic mnemonic tasks. By contrast, a more severe impairment follows damage to the mid-ventrolateral frontal region and functional activation studies have demonstrated specific changes in activity in this region in relation to the active retrieval of information from memory.

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Study on the Postprandial Blood Glucose Suppression Effect ofD-Psicose in Borderline Diabetes and the Safety of Long-Term Ingestion by Normal Human Subjects

Bioscience Biotechnology and Biochemistry ◽

10.1271/bbb.90707 ◽

2010 ◽

Vol 74 (3) ◽

pp. 510-519 ◽

Cited By ~ 85

Author(s):

Noriko HAYASHI ◽

Tetsuo IIDA ◽

Takako YAMADA ◽

Kazuhiro OKUMA ◽

Isao TAKEHARA ◽

...

Keyword(s):

Blood Glucose ◽

Human Subjects ◽

Postprandial Blood Glucose ◽

Suppression Effect ◽

Normal Human ◽

Borderline Diabetes

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Effect of long-term treatment with L-deprenyl on the age-dependent microanatomical changes in the rat hippocampus

Mechanisms of Ageing and Development ◽

10.1016/0047-6374(94)01559-5 ◽

1995 ◽

Vol 79 (2-3) ◽

pp. 169-185 ◽

Cited By ~ 18

Author(s):

Yong-Chun Zeng ◽

Stefano Bongrani ◽

Elena Bronzetti ◽

Sandro Cadel ◽

Alberto Ricci ◽

...

Keyword(s):

Term Treatment ◽

Rat Hippocampus ◽

Long Term Treatment ◽

Age Dependent

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Seizure induced synthesis of fibronectin is rapid and age dependent: implications for long-term potentiation and sprouting

Brain Research ◽

10.1016/s0006-8993(98)00727-6 ◽

1998 ◽

Vol 812 (1-2) ◽

pp. 209-215 ◽

Cited By ~ 34

Author(s):

Keith B Hoffman ◽

Jason K Pinkstaff ◽

Christine M Gall ◽

Gary Lynch

Keyword(s):

Long Term Potentiation ◽

Term Potentiation ◽

Age Dependent

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The effects of As(III), Cu(II) and Hg(II) on the expression of MRP-transporters in long-term cultures of normal human bronchial epithelial cells

Toxicology Letters ◽

10.1016/j.toxlet.2006.06.031 ◽

2006 ◽

Vol 164 ◽

pp. S12-S13

Author(s):

Felix Glahn ◽

Michaela Jambor ◽

Abdel W Torky ◽

Ekkehard Stehfest ◽

Stefan Hofmann ◽

...

Keyword(s):

Epithelial Cells ◽

Bronchial Epithelial Cells ◽

Normal Human Bronchial Epithelial ◽

Human Bronchial Epithelial Cells ◽

Bronchial Epithelial ◽

Normal Human

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PLA-Based Hybrid and Composite Electrospun Fibrous Scaffolds as Potential Materials for Tissue Engineering

Journal of Nanomaterials ◽

10.1155/2017/9246802 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 9

Author(s):

Anna Magiera ◽

Jarosław Markowski ◽

Elzbieta Menaszek ◽

Jan Pilch ◽

Stanislaw Blazewicz

Keyword(s):

Tissue Engineering ◽

Mechanical Tests ◽

Hybrid Structures ◽

Poly Lactic Acid ◽

Electrospinning Technique ◽

Water Contact ◽

Human Osteoblasts ◽

Angle Measurements ◽

Contact Angle Measurements ◽

Normal Human

The aim of the study was to manufacture poly(lactic acid)- (PLA-) based nanofibrous nonwovens that were modified using two types of modifiers, namely, gelatin- (GEL-) based nanofibres and carbon nanotubes (CNT). Hybrid nonwovens consisting of PLA and GEL nanofibres (PLA/GEL), as well as CNT-modified PLA nanofibres with GEL nanofibres (PLA + CNT/GEL), in the form of mats, were manufactured using concurrent-electrospinning technique (co-ES). The ability of such hybrid structures as potential scaffolds for tissue engineering was studied. Both types of hybrid samples and one-component PLA and CNTs-modified PLA mats were investigated using scanning electron microscopy (SEM), water contact angle measurements, and biological and mechanical tests. The morphology, microstructure, and selected properties of the materials were analyzed. Biocompatibility and bioactivity in contact with normal human osteoblasts (NHOst) were studied. The coelectrospun PLA and GEL nanofibres retained their structures in hybrid samples. Both types of hybrid nonwovens were not cytotoxic and showed better osteoinductivity in comparison to scaffolds made from pure PLA. These samples also showed significantly reduced hydrophobicity compared to one-component PLA nonwovens. The CNT-contained PLA nanofibres improved mechanical properties of hybrid samples and such a 3D system appears to be interesting for potential application as a tissue engineering scaffold.

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