Bone quality: A determinant for certain risk factors for bone fragility

1993 ◽  
Vol 53 (S1) ◽  
pp. S27-S31 ◽  
Author(s):  
Christine M. Schnitzler
Keyword(s):  
Risk Factors ◽  
Bone Quality ◽  
Bone Fragility

scholarly journals The survival rates and risk factors of implants in the early stage: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yong Yang ◽  
Huiting Hu ◽  
Mianyan Zeng ◽  
Hongxing Chu ◽  
Zekun Gan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Survival Rate ◽  
Dental Implants ◽  
Bone Quality ◽  
Early Stage ◽  
Survival Rates ◽  
Bone Augmentation ◽  
Early Survival ◽  
Immediate Implantation ◽  
Implant Length

Abstract Background Few large-sample studies in China have focused on the early survival of dental implants. The present study aimed to report the early survival rates of implants and determine the related influencing factors. Methods All patients receiving dental implants at our institution between 2006 and 2017 were included. The endpoint of the study was early survival rates of implants, according to gender, age, maxilla/mandible, dental position, bone augmentation, bone augmentation category, immediate implant, submerged implant category, implant diameter, implant length, implant torque, and other related factors. Initially, SPSS22.0 was used for statistical analysis. The Chi-square test was used to screen all factors, and those with p < 0.05 were further introduced into a multiple logistic regression model to illustrate the risk factors for early survival rates of implants. Results In this study, we included 1078 cases (601 males and 477 females) with 2053 implants. After implantation, 1974 implants were retained, and the early survival rate was 96.15%. Patients aged 30–60 years (OR  2.392), with Class I bone quality (OR  3.689), bone augmentation (OR  1.742), immediate implantation (OR  3.509), and implant length < 10 mm (OR  2.972), were said to possess risk factors conducive to early survival rates. Conclusions The early survival rate of implants in our cohort exceeded 96%, with risk factors including age, tooth position, bone quality, implant length, bone augmentation surgery, and immediate implantation. When the above factors coexist, implant placement should be treated carefully.

scholarly journals Development of diabetes-sensitive fracture resistance analysis using finite element method to predict diabetic bone fragility and bone quality

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100883
Author(s):  
Cemre Yavuz ◽  
Eva Maria Wölfel ◽  
Katharina Jähn-Rickert ◽  
Herbert Mushumba ◽  
Birgit Wulff ◽  
...  
Keyword(s):  
Finite Element Method ◽  
Finite Element ◽  
Bone Quality ◽  
Fracture Resistance ◽  
Bone Fragility ◽  
Resistance Analysis ◽  
Element Method

scholarly journals DIAGNOSIS OF ENDOCRINE DISEASE: Evaluation of bone fragility in endocrine disorders

2019 ◽  
Vol 180 (6) ◽  
pp. R213-R232 ◽  
Author(s):  
Cristina Eller-Vainicher ◽  
Alberto Falchetti ◽  
Luigi Gennari ◽  
Elisa Cairoli ◽  
Francesco Bertoldo ◽  
...  
Keyword(s):  
Bone Density ◽  
Fracture Risk ◽  
Bone Quality ◽  
Risk Estimation ◽  
Underlying Disease ◽  
Bone Fragility ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Endocrine Diseases ◽  
Density Evaluation

An underlying disease affecting bone health is present in up to 40 and 60% of osteoporotic postmenopausal women and men respectively. Among the disorders leading to a secondary form of osteoporosis, the endocrine diseases are highly represented. A frequent finding in patients affected with an endocrine-related forms of bone disease is that the skeletal fragility is partially independent of the bone density, since the fracture risk in these patients is related more to a reduction of bone quality than to a decrease of bone mass. As a consequence, bone mineral density evaluation by dual-X-ray absorptiometry may be inadequate for establishing the risk of fracture in the setting of the endocrine-related forms of osteoporosis. In the recent years, several attempts to non-invasively estimating bone quality have been done. Nowadays, some new tools are available in the clinical practice for optimising the fracture risk estimation in patients with endocrine disorders. The aim of this review is to summarise the evidence regarding the role of the different imaging tools for evaluating bone density and bone quality in the most frequent forms of endocrine-related osteoporosis, such as obesity, diabetes, acromegaly, thyrotoxicosis, primary hyperparathyroidism, hypercortisolism and hypogonadism. For each of these disorders, data regarding both the current available tools and the future possible new techniques for assessing bone fragility in patients with endocrine diseases are reported.

scholarly journals An 11-Year Retrospective Research Study of the Predictive Factors of Peri-Implantitis and Implant Failure: Analytic-Multicentric Study of 1279 Implants in Peru

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Frank Mayta-Tovalino ◽  
Yens Mendoza-Martiarena ◽  
Percy Romero-Tapia ◽  
María Álvarez-Paucar ◽  
Luis Gálvez-Calla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Dental Implants ◽  
Bone Quality ◽  
Private Institutions ◽  
Multivariate Logistic Regression ◽  
Public And Private ◽  
Multicentric Study ◽  
Kaplan Meier ◽  
History Of

Aim. To analyze the risk factors by logistic regression and perform the analysis of the survival rate of osseointegrated dental implants placed in public and private institutions. Methods. An analytic-multicentric study was carried out, where 1279 dental implants that were placed by specialists from January 2006 to October 2017 in public and private institutions (UPCH-SI, HCFAP, CMNAVAL, UPCH-SM, and UPSJB) were evaluated. The variables sex (X1), location (X2), hypertension (X3), antibiotic prophylaxis (X4), diabetes (X5), osteoporosis (X6), bisphosphonates (X7), history of periodontitis (X8), hypercholesterolemia (X9), bone quality (X10), bone quantity (X11), design (X12), smoker (X13), connection (X14), edentulism type (X15), staging (X16), 3D guided surgery (X17), load (X18), bone graft (X19), peri-implantitis (X20), mucositis (X21), and GBR (X22) were collected and analyzed by the Kaplan–Meier survival analysis. The logit analysis was performed among all the variables to choose the best statistical model that explains the true risk factors. The analysis was performed by multivariate logistic regression and the Kaplan–Meier test, at a level of statistical significance of p<0.05. Results. It was found that the failure rate of the 1279 implants evaluated was 17.98% corresponding to only 23 implants lost as they have good longevity over time. When establishing the best multivariate logistic regression model, it was found that the variables that remained stable in relation to their statistically significant value and more stable confidence intervals were age, osteoporosis, bisphosphonates, history of periodontitis, bone quality, bone graft, connection, number of implants, GBR (guided bone regeneration), and follow-up. Conclusions. Dental implants placed by specialists in public and private institutions had a failure rate similar to that in studies previously published in other countries.

scholarly journals Experimental Hyperhomocysteinemia Reduces Bone Quality in Rats

2007 ◽  
Vol 53 (8) ◽  
pp. 1455-1461 ◽  
Author(s):  
Markus Herrmann ◽  
Britt Wildemann ◽  
Lutz Claes ◽  
Stefan Klohs ◽  
Michael Ohnmacht ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Bone Quality ◽  
Distal Femur ◽  
Bone Fragility ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Bone Area ◽  
Bone Formation Marker ◽  
Turnover Markers

Abstract Background: Recently, hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. This study investigated if HHCY is a causal osteoporotic factor in vivo. Methods: We used 3 groups of rats: a control group (n = 20), a moderate HHCY group (induced by a 2.4% methionine-enriched diet, n = 10), and an intermediate HHCY group (induced by a 2% homocystine-enriched diet, n = 10). We measured bone fragility [maximum force of an axial compression test (Fmax)], bone area as percentage of total area (BAr/TAr, histomorphometry), and biochemical bone turnover markers [osteocalcin (OC) and collagen I C-terminal crosslaps (CTx)]. Results: Compared with controls, 3 months of moderate or intermediate HHCY increased mean (SD) bone fragility at the femoral neck by 18% (6%) in methionine-fed (P = 0.001) and 36% (13%) in homocystine-fed rats (P &lt;0.001). Mean (SD) BAr/TAr at the distal femur in methionine and homocystine groups was decreased by 45% (21%; P = 0.001) and 93% (9%; P = 0.001), respectively. At the femoral neck, BAr/TAr was decreased by 19% (11%; P &lt;0.001) and 55% (19%; P &lt;0.001). At the lumbar spine, the reduction of BAr/TAr was 17% (23%; P = 0.099) and 44% (19%; P &lt;0.001). Plasma OC (bone formation marker) was decreased by 23% (20%; P = 0.006) and 34% (21%; P &lt;0.001). Plasma CTx (bone resorption marker) did not differ between groups. Conclusion: Bone quality is consistently decreased in the presence of increased circulating homocysteine. The results provide evidence that HHCY is a causal osteoporotic factor.

scholarly journals Fragility fractures and bone remodeling in type 2 diabetes mellitus

2017 ◽  
Vol 14 (3) ◽  
pp. 11-18 ◽  
Author(s):  
Tatiana O. Yalochkina ◽  
Zhanna E. Belaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Bone Fragility ◽  
Mineral Density ◽  
Severe Diabetes ◽  
Increased Risk

Fracture risk is significantly increased in both type 1 and type 2 diabetes and individuals with diabetes experience worse fracture outcomes compared to normoglycemic individuals. Patients with T1DM have decreased bone mineral density (BMD), whereas patients with T2DM demonstrate increased BMD compared to healthy control. The latest studies show increased incidence of low-traumatic fractures in patients with T2DM instead of high bone mineral density (BMD). The risk of osteoporotic fractures in patients with T2DM can be explained by disease complications and increased risk of falls and consequent trauma. However, the most important cause of bone fragility in T2DM is the deterioration in bone microarchitecture, the mechanism of which is not completely understood. High BMD in patients with T2DM does not allow us to use dual-energy X-ray-absorptiometry as a gold standard test for diagnosticsof osteoporosis. Consequently,new risk factors and diagnostic algorithm as well as treatment strategy should be developed for patients with T2DM. In addition to this, some researchers considered that the group of T2DM is geterogenous and physicians might face patients with osteoporosis and mild diabetes that add very little to bone fragility; patients with osteoporosis and moderate or severe diabetes which also affects bone tissue diabetoosteoporosis; and patients without osteoporosis but severe diabetes which cause bone tissue deterioration with the development of diabetic bone disease. New diagnostic tools and algorithm and new experimental research are needed for better understanding bone deterioration in patients with T2DM. This review summarizes our current knowledge on fracture rate, risk factors for fractures and causes of bone deterioration in subjects with T2DM.

scholarly journals Phenomenon of osteocyte lacunar mineralization: indicator of former osteocyte death and a novel marker of impaired bone quality?

2020 ◽  
Vol 9 (4) ◽  
pp. R70-R80 ◽  
Author(s):  
Petar Milovanovic ◽  
Björn Busse
Keyword(s):  
Bone Quality ◽  
Bone Fractures ◽  
Current Knowledge ◽  
Bone Fragility ◽  
Osteoporotic Bone ◽  
Endocrine Disorders ◽  
Osteocyte Lacunae ◽  
Number Of Patients ◽  
Osteocyte Death ◽  
Osteocyte Lacunar

An increasing number of patients worldwide suffer from bone fractures that occur after low intensity trauma. Such fragility fractures are usually associated with advanced age and osteoporosis but also with long-term immobilization, corticosteroid therapy, diabetes mellitus, and other endocrine disorders. It is important to understand the skeletal origins of increased bone fragility in these conditions for preventive and therapeutic strategies to combat one of the most common health problems of the aged population. This review summarizes current knowledge pertaining to the phenomenon of micropetrosis (osteocyte lacunar mineralization). As an indicator of former osteocyte death, micropetrosis is more common in aged bone and osteoporotic bone. Considering that the number of mineralized osteocyte lacunae per bone area can distinguish healthy, untreated osteoporotic and bisphosphonate-treated osteoporotic patients, it could be regarded as a novel structural marker of impaired bone quality. Further research is needed to clarify the mechanism of lacunar mineralization and to explore whether it could be an additional target for preventing or treating bone fragility related to aging and various endocrine diseases.

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