An immunohistochemical and immunoelectron microscopic study of adhesion molecules in synovial pannus formation in rheumatoid arthritis

Background: Rheumatoid arthritis is a systemic multifactor disease that presented with symmetrical polyarthritis more preferably in small wrist joint and ankle. Synovial pannus cause destruction and deformities in joints. The main reason of this disease in unknown, but past researchesshowed that genetically factor play important role beside environmental factors in susceptibility to this entity. Method:100 patients with rheumatoid arthritis diagnosed upon ACR 2010 criteria enrolled study. 92 healthy patents also enrolled DNA studying. of both group was extracted through DNA extraction kits by blood sampling. HLA-DRB1 typing was done by PCR-SSP method. Results: There were no significant differences in HLADRB1 *04, HLADRB1*08 and HLADRB1*11 alleles presentation between patients and healthy controls. Only there were statically significant correlation between HLA-DRB1*08 and Rheumatoid factor positive patents. (P = 0.025).

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Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients

European Journal of Immunology ◽

10.1002/eji.1830221119 ◽

1992 ◽

Vol 22 (11) ◽

pp. 2879-2885 ◽

Cited By ~ 41

Author(s):

Hiroki Takahashi ◽

Kalle Söderström ◽

Ethel Nilsson ◽

Rolf Kiessling ◽

Manuel Patarroyo

Keyword(s):

Rheumatoid Arthritis ◽

Synovial Fluid ◽

Adhesion Molecules ◽

Peripheral Blood

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Advancement of Natural Compounds as Anti- Rheumatoid Arthritis Agents: Focus on Their Mechanism of Actions

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521666210304112916 ◽

2021 ◽

Vol 21 ◽

Author(s):

Huanghe Yu ◽

Yixing Qiu ◽

Shumaila Tasneem ◽

Muhammad Daniyal ◽

Bin Li ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Molecular Mechanisms ◽

Bone Destruction ◽

Inflammatory Cells ◽

Chronic Inflammatory Disease ◽

Mechanisms Of Action ◽

Pannus Formation ◽

Synovial Hyperplasia ◽

Naturally Occurring ◽

Natural Plants

: Rheumatoid arthritis (RA) is a chronic inflammatory disease categorized by infiltration of inflammatory cells, synovial hyperplasia, pannus formation and bone destruction, leading to disability worldwide. Despite the presence of the commercial availability of anti-RA agent on the market, the application of these drugs is limited due to its side effects. Anti-rheumatic drugs are more effective and safer being investigated by many researchers, especially, natural products with anti-RA have been identified and the underlying molecular mechanisms of action of novel and known compounds have been reported. In this review, we intend to provide a comprehensive view and updated on naturally occurring compounds known and novel that has the effect of anti-RA, and then classify them according to their molecular mechanisms of action in regulating the anti-RA lane main. The safety of compounds from natural plants and western medicine has also been briefly compared. In addition, the clinical trials with anti-RA compounds isolated from natural plants in RA were also summarized in this manuscript.

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