Influence of oral contraceptive treatment on blood pressure and 24-hour urinary catecholamine excretion in smoking as compared with non-smoking women

Androgen-dependent dermopathy, as well as premenstrual syndrome of varying severity in young women, can cause emotional depression, difficulties in social adaptation and even depressive disorders. The aim of the study was to study the safety and efficacy of using a combined oral contraceptive (COC) Dimia® containing 20 μg ethinyl estradiol and 3 mg drospirenone in young women, as well as its therapeutic effects in androgen-dependent dermopathy. Materials and methods. The study included 57 young women aged 23.1±2.2 years with signs of androgen-dependent dermopathy. The evaluation of the change in the character of menstrual bleeding, the anthropometric parameters (body weight, waist circumference and hips), the therapeutic effect of the drug on the symptoms of androgen-dependent dermopathy, as well as the dynamics of arterial pressure, hemoglobin level, serum iron have been studied. The psycho-emotional state was assessed using the SAN questionnaire (well-being-activity-mood). Results. During 6 months of observation, there was no significant change in the body mass index, waist circumference, and hips, and the drug did not affect the blood pressure numbers. Against the background of taking the drug, there was an increase in the parameters of iron metabolism (hemoglobin content, serum iron). After 3 months of taking the contraceptive with drospirenone, the number of patients with a complaint about the abundance of menstruation decreased more than twofold (from 22.8 to 10.5%), and after 6 months of taking the drug no patient noted the profuse nature of menstruation. Before the start of taking COC with drospirenone, 57.9% of women reported painful menstrual bleeding. Against the background of taking the contraceptive within 3 months, this complaint was stopped in all patients. Sufficient efficacy of treatment of androgen dependent dermopathy in young women with the help of a microdosed drospirenone-containing combined oral contraceptive is estimated from the dermatological acne index. The analysis of the SAN questionnaire made it possible to reveal the improvement in the psychoemotional state of patients on the background of taking the drug. The conclusion. The results obtained proved the effectiveness and safety of the microclinized COC Dimia®. The drug has no significant effect on body weight, blood pressure, provides reliable control of the cycle and a decrease in menstrual bleeding, which results in stabilization of iron metabolism in the body. Dimia® is effective in the treatment of androgen-dependent dermopathy and can be recommended to young women for starting contraception.

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URINARY CATECHOLAMINE EXCRETION BY HEALTHY CHILDREN

PEDIATRICS ◽

10.1542/peds.39.2.252 ◽

1967 ◽

Vol 39 (2) ◽

pp. 252-257

Author(s):

Mary L. Voorhess

Keyword(s):

Urinary Excretion ◽

Surface Area ◽

Body Surface Area ◽

Body Surface ◽

Age Groups ◽

Healthy Children ◽

Urinary Catecholamine ◽

Catecholamine Excretion ◽

Daily Output ◽

The Mean

There is increase in the daily urinary excretion of dopamine (DA), norepinephrine (NE), epinephrine (E), and 3-methoxy-4-hydroxymandelic acid (VMA) with age. The mean output in micrograms per 24 hours for various age groups is as follows: birth to 1 year-DA 60.9 (± 24.3), NE 10.6 (± 3.4), E 1.3 (± 1.2), VMA 569 (± 309); 1 through 5 years—DA 124.1 (± 40.7), NE (18.8 ± 7.0), E 3.2 (± 2.7), VMA 1348 (± 433); 6 through 15 years—DA 169.3 (± 72.6), NE 37.4 (± 16.6), E 4.8 (± 2.4), VMA 2373 (± 698); over 15 years—DA 249.1 (± 74.9), NE 50.7 (± 15.7), E 7.1 (± 3.3), VMA 3192 (± 699). The studies suggest that the daily output of these compounds in the various age groups is similar when related to body surface area after infancy.

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Catecholamine Excretion and Circadian Blood Pressure Profile in Patients with Pheochromocytoma

Annals of the New York Academy of Sciences ◽

10.1196/annals.1353.008 ◽

2006 ◽

Vol 1073 (1) ◽

pp. 79-85 ◽

Cited By ~ 2

Author(s):

E. DABROWSKA ◽

J. LEWANDOWSKI ◽

P. JEDRUSIK ◽

B. SYMONIDES ◽

B. WOCIAL ◽

...

Keyword(s):

Blood Pressure ◽

Pressure Profile ◽

Catecholamine Excretion ◽

Circadian Blood Pressure ◽

Blood Pressure Profile ◽

Circadian Blood Pressure Profile

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Urinary Catecholamine Excretion and Severity of PTSD Symptoms in Vietnam Combat Veterans

The Journal of Nervous and Mental Disease ◽

10.1097/00005053-199205000-00006 ◽

1992 ◽

Vol 180 (5) ◽

pp. 321-325 ◽

Cited By ~ 196

Author(s):

RACHEL YEHUDA ◽

STEVEN SOUTHWICK ◽

EARL L. GILLER ◽

&NA; XIAOWAN ◽

JOHN W. MASON

Keyword(s):

Combat Veterans ◽

Ptsd Symptoms ◽

Urinary Catecholamine ◽

Catecholamine Excretion ◽

Vietnam Combat Veterans

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Pattern of Fasting Blood Sugar, Blood Pressure and Body Mass Index among Combined Oral Contraceptive (COC) Pills Users in Chencha, Southern Ethiopia: a cross-sectional study

10.21203/rs.2.19624/v1 ◽

2019 ◽

Author(s):

Zelalem Kofole ◽

Diresbachew Haile ◽

Yerukneh Solomon ◽

Eyayu Girma

Keyword(s):

Blood Pressure ◽

Body Mass Index ◽

Oral Contraceptive ◽

Blood Sugar ◽

Arterial Blood Pressure ◽

Body Mass ◽

Mean Arterial Blood Pressure ◽

Fasting Blood Sugar ◽

Cross Sectional ◽

Arterial Blood

Abstract Background: The use of contraceptives has become prevalent among women in Ethiopia. Oral contraceptive use has been suggested to trigger changes in glucose metabolism, energy expenditure, blood pressure, and body weight, among the various populations and ethnic groups. Objective: To elucidate the pattern of fasting blood sugar (FBS), blood pressure and body mass index (BMI) among combined oral contraceptive (COC) pills users, taking into account other confounding factors including socioeconomic conditions and physical activity status. Methods: An institution based cross-sectional study design was employed. A total of 110 healthy women using pills were recruited as cases. Another 110 healthy women not using any hormonal contraceptives were recruited as matched controls. A study was conducted between October 2018 and January 2019. Fasting Capillary blood sample was collected from the study participants for the estimation of the FBS level. Systolic and diastolic blood pressures were measured and means arterial blood pressure was calculated for each participant. Body weight and height were measured to compute body mass index. Data obtained was entered and analyzed using IBM SPSS version 23 software packages. Results: FBS level in users was significantly increased compared to controls (88.55 ± 7.89 vs. 86.00 ± 9.85 in users and controls respectively, P = 0.025). There was a significant difference in mean arterial blood pressure of users compared to controls (88.2 ± 8.48 vs. 86.0 ± 6.74 respectively, P=0.04). The mean weight and body mass index of users were significantly increased (P = 0.03 and P = 0.003, respectively). Changes in mean fasting blood sugar level and mean weight of users were independent (P = 0.27 and P = 0.46) to the duration of use (3-12, 13-24 and ≥ 25 months). On the other hand, changes in mean body mass index and mean arterial blood pressure of users were dependent of the duration of use (P = 0.03 and P = 0.000 respectively). Conclusions: Overall, oral contraceptive pills use appears to cause a 2.9% increase in fasting blood glucose level, a 2.5% increase in mean arterial blood pressure and a 3.9% increase in body mass index among the users.

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Ovulatory potential of preovulatory sized follicles during oral contraceptive treatment

Contraception ◽

10.1016/s0010-7824(99)00094-3 ◽

1999 ◽

Vol 60 (5) ◽

pp. 275-279 ◽

Cited By ~ 12

Author(s):

Kaisa Elomaa ◽

Pekka Lähteenmäki

Keyword(s):

Oral Contraceptive ◽

Contraceptive Treatment

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THE VALUE OF SERIAL CATECHOLAMINE DETERMINATIONS IN CHILDREN WITH NEUROBLASTOMA

PEDIATRICS ◽

10.1542/peds.30.2.241 ◽

1962 ◽

Vol 30 (2) ◽

pp. 241-246

Author(s):

Mary L. Voorhess ◽

Lytt I. Gardner

Keyword(s):

Clinical Evidence ◽

Recurrent Disease ◽

Surgical Removal ◽

Urinary Catecholamine ◽

Urinary Catecholamines ◽

Surgical Exploration ◽

Catecholamine Excretion ◽

Urinary Dopamine ◽

The Right ◽

Superior Pole

Urinary catecholamine excretion was measured in a 4-year-old child with neuroblastoma arising from the right adrenal. Initially urinary dopamine and norepinephrine output was high. Because the tumor was inoperable a course of radiation therapy and chemotherapy was given. Following this treatment catecholamine excretion decreased but never reached normal levels. Although there was no clinical evidence of persistent tumor, the elevated urinary output of dopamine and norepinephrine indicated residual neuroblastoma. Therefore surgical exploration was performed and tumor was found overlying the superior pole of the right kidney. After removal of this persistent neuroblastoma the urinary excretion of catecholamines returned to normal and remained at this level. The child has no evidence of recurrent disease and appears healthy. To our knowledge this represents the first reported case wherein the indication for surgical removal of residual neuroblastoma was based solely on elevated output of urinary catecholamines.

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