Blood Pressure and Urinary Catecholamine Excretion Vary Inversely with Rate of Weight Gain in Low Birth Weight (LBW) Infants

Abstract Objectives Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight. Results Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs − 0.45 ± 1.47, p = 0.045) and a greater proportion of current obesity (42% vs 2.5%, p < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 34.77, 95%CI 1.814–666.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.

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P2-156 Salivary cortisol and blood pressure response to cold pressor test in very low birth weight infants at

Early Human Development ◽

10.1016/s0378-3782(07)70489-9 ◽

2007 ◽

Vol 83 ◽

pp. S173

Author(s):

L.K. Washburn ◽

P.A. Nixon ◽

T.M. O'Shea ◽

Wake Forest

Keyword(s):

Blood Pressure ◽

Birth Weight ◽

Low Birth Weight ◽

Salivary Cortisol ◽

Very Low Birth Weight ◽

Blood Pressure Response ◽

Cold Pressor Test ◽

Cold Pressor ◽

Low Birth Weight Infants ◽

Pressor Test

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SYSTEMIC HYPERTENSION FOLLOWING OCULAR ADMINISTRATION OF 10% PHENYLEPHRINE IN THE NEONATE

PEDIATRICS ◽

10.1542/peds.51.6.1032 ◽

1973 ◽

Vol 51 (6) ◽

pp. 1032-1036 ◽

Cited By ~ 1

Author(s):

Virginia Borromeo-McGrail ◽

Joseph Bordiuk ◽

Hans Keitel

Keyword(s):

Blood Pressure ◽

Birth Weight ◽

Low Birth Weight ◽

Systemic Blood Pressure ◽

Systemic Effect ◽

Systemic Hypertension ◽

Double Blind Study ◽

Eye Drops ◽

Low Birth Weight Infants ◽

Double Blind

The effect of ophthalmic instillation of 10% phenylephrine on systemic blood pressure in the neonate has not been previously evaluated, despite reports of adverse reactions. The effect of 10% and 2½% phenylephrine eye drops in healthy low birth weight neonates was compared in a double-blind study. Blood pressure showed a rise of 12 to 16 mm Hg in systole and 10 to 14 mm Hg in diastole following administration of 10% phenylephrine. Blood pressure remained stable in infants receiving 2½% phenylephrine. Consistent, although more variable, increases in blood pressure were noted in eight low birth weight infants given 10% phenylephrine eye drops in a nonblind study. Complete mydriasis was achieved with 2½% phenylephrine as well as with 10%. Neither concentration had an effect on pulse or respiratory rates. Cutaneous administration of either 10% or 2½% phenylephrine to abdominal skin produced local blanching but no systemic effect. To avoid potentially dangerous sequelae from iatrogenic hypertension, it is recommended that not more than one drop of 2½% phenylephrine in each eye be administered to neonates for mydriasis.

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High Blood Pressure during Pregnancy is not a Protective Factor for Preterm Infants with Very Low Birth Weight. A Case-Control Study

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0037-1601883 ◽

2017 ◽

Vol 39 (04) ◽

pp. 155-161 ◽

Cited By ~ 1

Author(s):

Annibal Sabino ◽

Eduardo de Souza ◽

Ana Goulart ◽

Adriana Lima ◽

Nelson Sass

Keyword(s):

Blood Pressure ◽

Birth Weight ◽

Low Birth Weight ◽

Protective Factor ◽

Case Control Study ◽

Very Low Birth Weight ◽

Case Control ◽

World Health ◽

Control Group ◽

Control Study

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.

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