The expression and biological activity of IL-2 receptor on a human pancreas cancer cell line

Biotherapy ◽  
1993 ◽  
Vol 6 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Hiroyuki Kawami ◽  
Kazuhiro Yoshida ◽  
Yoshiyuki Yamaguchi ◽  
Toshiaki Saeki ◽  
Tetsuya Toge
Keyword(s):  
Biological Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreas Cancer ◽  
Cancer Cell Line ◽  
Human Pancreas

Antiproliferative Effect of Angelica archangelica Fruits

2004 ◽  
Vol 59 (7-8) ◽  
pp. 523-527 ◽  
Author(s):  
Steinthor Sigurdsson ◽  
Helga M. Ögmundsdottir ◽  
Sigmundur Gudbjarnason
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Antiproliferative Activity ◽  
Pancreas Cancer ◽  
Cancer Cell Line ◽  
Antiproliferative Effect ◽  
Human Pancreas ◽  
Active Components ◽  
Angelica Archangelica ◽  
Dose Dependent

AbstractThe aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 μg/ml. Strong antiproliferative activity resulted from the two most abundant furanocoumarins in the tincture, imperatorin and xanthotoxin. The contribution of terpenes to this activity was insignificant. Imperatorin and xanthotoxin proved to be highly antiproliferative, with EC50 values of 2.7 μg/ml and 3.7 μg/ml, respectively, equivalent to 10 and 17 μm. The results indicate that furanocoumarins account for most of the antiproliferative activity of the tincture.

scholarly journals SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

2017 ◽  
Vol 126 (1B) ◽  
pp. 127
Author(s):  
Duong Quoc Hoan
Keyword(s):  
Biological Activity ◽  
Acetic Anhydride ◽  
Cell Line ◽  
Cancer Cell ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
High Yield ◽  
Curcumin Analog ◽  
Isoxazole Ring ◽  
Activity Evaluation

The acetohydrazides <strong>A5 </strong>containing an isoxazole ring and<strong> B5</strong> containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones <strong>B6</strong> and <strong>B7</strong> were driven from acetohydrazide <strong>B4</strong> by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  <strong>B7</strong> showing moderate reactivity against KB cancer cell line at <em>IC<sub>50</sub></em> = 57 mg/L.

MIA PaCa-2 pancreas cancer cell line – Therapeutic (metabolic radiotherapy and chemotherapy) trials

Pancreatology ◽  
2012 ◽  
Vol 12 (6) ◽  
pp. 548
Author(s):  
R. Gradiz ◽  
A.M. Abrantes ◽  
A.C. Mamede ◽  
M.F. Botelho ◽  
A. Mota-Pinto
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Pancreas Cancer ◽  
Cancer Cell Line ◽  
Metabolic Radiotherapy

MIA PaCa-2 pancreas cancer cell line – Phenotypic and genotypic characterization

Pancreatology ◽  
2012 ◽  
Vol 12 (6) ◽  
pp. 547
Author(s):  
R. Gradiz ◽  
L. Carvalho ◽  
H. Silva ◽  
R.J. Nobre ◽  
M.F. Botelho ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Pancreas Cancer ◽  
Cancer Cell Line ◽  
Genotypic Characterization ◽  
Phenotypic And Genotypic Characterization

scholarly journals The Nutritional Value and Biological Activity of Concentrated Protein Fraction of Potato Juice

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1523 ◽  
Author(s):  
Przemysław Łukasz Kowalczewski ◽  
Anna Olejnik ◽  
Wojciech Białas ◽  
Iga Rybicka ◽  
Magdalena Zielińska-Dawidziak ◽  
...  
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Protein Fraction ◽  
Nutritional Value ◽  
Cancer Cell Line ◽  
Protein Concentrate ◽  
Cytotoxicity Studies

Potato protein is recognized as one of the most valuable nonanimal proteins due to the high content of essential amino acids. So far, it has not been used in human nutrition on a large scale due to technological limitations regarding its acquisition. In this study, the protein fraction of potato juice was concentrated with the use of membrane separation. The obtained potato juice protein concentrate (PJPC) was characterized in terms of nutritional value and biological activity, and the amino acid composition, mineral content, and antioxidant properties were determined. Moreover, in vitro cytotoxic activity against cancer cells of the gastrointestinal tract was investigated. The results of the present study indicate that PJPC is an excellent source of lysine and threonine, while leucine is its limiting amino acid, with an amino acid score (AAS) of 65%. Moreover, PJPC contains substantial amounts of Fe, Mn, K, and Cu. As demonstrated experimentally, PJPC is also characterized by higher antioxidant potential than potato itself. Biological activity, however, is not limited to antioxidant activity alone. Cytotoxicity studies using a gastric cancer cell line (Hs 746T), a colon cancer cell line (HT-29), and human colon normal cells (CCD 841 CoN) proved that PJPC is characterized by selective activity against cancer cells. It can thus be concluded that the developed method of producing protein concentrate from potato juice affords a product with moderate nutritional value and interesting biological activity.

scholarly journals LeyExpression and Procoagulant Activity of Pancreas Cancer Cell Line MIAPaCa -II induced by Apoptosis

1998 ◽  
Vol 31 (10) ◽  
pp. 2181-2181
Author(s):  
Yukihiko Hashimoto ◽  
Haruhiko Inufusa ◽  
Toshiyuki Adachi ◽  
Sadao Funai ◽  
Tsukasa Wakano ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Pancreas Cancer ◽  
Cancer Cell Line ◽  
Procoagulant Activity

scholarly journals SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

2017 ◽  
Vol 126 (1B) ◽  
Author(s):  
Dương Quốc Hoàn
Keyword(s):  
Biological Activity ◽  
Acetic Anhydride ◽  
Cell Line ◽  
Cancer Cell ◽  
Condensation Reaction ◽  
Cancer Cell Line ◽  
High Yield ◽  
Curcumin Analog ◽  
Isoxazole Ring ◽  
Activity Evaluation

The acetohydrazides <strong>A5 </strong>containing an isoxazole ring and<strong> B5</strong> containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones <strong>B6</strong> and <strong>B7</strong> were driven from acetohydrazide <strong>B4</strong> by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones  <strong>B7</strong> showing moderate reactivity against KB cancer cell line at <em>IC<sub>50</sub></em> = 57 mg/L.

Ligation of fas antigen stimulates chemoline secretion in pancreatic cancer cell line PANC-1

2001 ◽  
Vol 120 (5) ◽  
pp. A336-A336
Author(s):  
M SHIMADA ◽  
A ANDOH ◽  
Y ARAKI ◽  
Y FUJIYAMA ◽  
T BAMBA
Keyword(s):  
Pancreatic Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Pancreatic Cancer Cell Line ◽  
Cancer Cell Line ◽  
Fas Antigen
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