SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION  OF SOME DERIVATIVES SYNTHESIZED  FROM CURCUMIN AND CURCUMIN ANALOG

The acetohydrazides A5 containing an isoxazole ring and B5 containing an indazole ring were synthesized from the corresponding acetohydrazide derivatives with acetic anhydride in about 80% high yield. Also, two acetohydrazones B6 and B7 were driven from acetohydrazide B4 by condensation reaction. Bioactivity testes showed that none of them were active against on bacteria except acetohydrazones B7 showing moderate reactivity against KB cancer cell line at IC50 = 57 mg/L.

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SYNTHESIS AND BIOLOGICAL ACTIVITY EVALUATION OF SOME DERIVATIVES SYNTHESIZED FROM CURCUMIN AND CURCUMIN ANALOG

HUE UNIVERSITY JOURNAL OF SCIENCE NATURAL SCIENCE ◽

10.26459/jns.v126i1b.4139 ◽

2017 ◽

Vol 126 (1B) ◽

Author(s):

Dương Quốc Hoàn

Keyword(s):

Biological Activity ◽

Acetic Anhydride ◽

Cell Line ◽

Cancer Cell ◽

Condensation Reaction ◽

Cancer Cell Line ◽

High Yield ◽

Curcumin Analog ◽

Isoxazole Ring ◽

Activity Evaluation

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The Nutritional Value and Biological Activity of Concentrated Protein Fraction of Potato Juice

Nutrients ◽

10.3390/nu11071523 ◽

2019 ◽

Vol 11 (7) ◽

pp. 1523 ◽

Cited By ~ 14

Author(s):

Przemysław Łukasz Kowalczewski ◽

Anna Olejnik ◽

Wojciech Białas ◽

Iga Rybicka ◽

Magdalena Zielińska-Dawidziak ◽

...

Keyword(s):

Biological Activity ◽

Amino Acid ◽

Cancer Cells ◽

Cell Line ◽

Cancer Cell ◽

Protein Fraction ◽

Nutritional Value ◽

Cancer Cell Line ◽

Protein Concentrate ◽

Cytotoxicity Studies

Potato protein is recognized as one of the most valuable nonanimal proteins due to the high content of essential amino acids. So far, it has not been used in human nutrition on a large scale due to technological limitations regarding its acquisition. In this study, the protein fraction of potato juice was concentrated with the use of membrane separation. The obtained potato juice protein concentrate (PJPC) was characterized in terms of nutritional value and biological activity, and the amino acid composition, mineral content, and antioxidant properties were determined. Moreover, in vitro cytotoxic activity against cancer cells of the gastrointestinal tract was investigated. The results of the present study indicate that PJPC is an excellent source of lysine and threonine, while leucine is its limiting amino acid, with an amino acid score (AAS) of 65%. Moreover, PJPC contains substantial amounts of Fe, Mn, K, and Cu. As demonstrated experimentally, PJPC is also characterized by higher antioxidant potential than potato itself. Biological activity, however, is not limited to antioxidant activity alone. Cytotoxicity studies using a gastric cancer cell line (Hs 746T), a colon cancer cell line (HT-29), and human colon normal cells (CCD 841 CoN) proved that PJPC is characterized by selective activity against cancer cells. It can thus be concluded that the developed method of producing protein concentrate from potato juice affords a product with moderate nutritional value and interesting biological activity.

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Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

Molecules ◽

10.3390/molecules23020279 ◽

2018 ◽

Vol 23 (2) ◽

pp. 279 ◽

Cited By ~ 8

Author(s):

Gabriel Silva ◽

Felipe Teixeira Lima ◽

Viviane Seba ◽

Ana Mendes Lourenço ◽

Thaise Lucas ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Line ◽

Cancer Cell ◽

Gastric Cancer Cell ◽

Gastric Cancer Cell Line ◽

Cancer Cell Line ◽

Migration And Invasion ◽

Human Gastric Cancer ◽

Curcumin Analog ◽

Human Gastric Cancer Cell

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Assessment of the Biological Activity of New Polycyclic Aromatic Hydrocarbons, on Aeromonas hydrophila and Cancer Cell Line

Egyptian Journal of Chemistry ◽

10.21608/ejchem.2021.95986.4500 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Fatima Rammadan Abdul ◽

Khetam Rasool ◽

Maysoon Abbas

Keyword(s):

Biological Activity ◽

Polycyclic Aromatic Hydrocarbons ◽

Cell Line ◽

Cancer Cell ◽

Aromatic Hydrocarbons ◽

Aeromonas Hydrophila ◽

Cancer Cell Line ◽

Polycyclic Aromatic

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Synthesis, Biological Evaluation and Docking Study of Etodolac-Triazole Conjugate

Chemical Science International Journal ◽

10.9734/csji/2020/v29i930204 ◽

2020 ◽

pp. 35-51

Author(s):

Papigani Neeraja ◽

Suryapeta Srinivas ◽

Venkanna Banothu ◽

Khagga Mukkanti ◽

Pramod Kumar Dubey ◽

...

Keyword(s):

Cell Line ◽

Cancer Cell ◽

Cancer Cell Line ◽

Triazole Ring ◽

Docking Study ◽

Biological Evaluation ◽

Lung Cancer Cell Line ◽

Human Lung Cancer ◽

High Yield ◽

Diffusion Method

A new set of 15 compounds containing etodolac moiety and triazole ring were prepared by CuAAC reaction in moderate to high yield. All the synthesized compounds were purified by chromatographic techniques and characterized by spectral data IR, 1H and 13C NMR and mass spectrometry. The newly derived compounds were screened for their anti-bacterial activities against one gram-positive (S. aureus) and two gram-negative (E. coli, K. pneumoniae) bacteria using an agar-well diffusion method. Most of the compounds showed good to moderate antibacterial activities. Especially compound 4e having good activities against all the strains. The compound 4e displayed signiﬁcant inhibitory potential with MIC 25 µg/mL against all the strains. The potential DNA gyrase inhibitory activity of this compound was investigated by using molecular docking studies carried out using Autodock Vina software. The compound 4e showed the lowest ΔGbind results (-7.7 Kcal/mol, -7.9Kcal/mol). The cytotoxic activity of the obtained compounds was determined using A549 cancer cell line by a MTT assay. They displayed promising activity against the human lung cancer cell line. Especially 4o, 4b, 4d shown lowest IC50 values.

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