The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart

Various pathologies, in particular hypertension, accompany violation of the processes of free radical oxidation. The state of the system lipid peroxidation – antioxidant protection can be assessed only by a complex of biochemical methods. The chemiluminescent method is used to obtain a faster result. The method has a number of advantages: measurement of chemiluminescence parameters is carried out in natural conditions and does not require sample preparation, is highly selective, it can be used to identify the presence of free radical pathology, analysis of the intensity of lipid peroxidation processes, the effectiveness of treatment with antioxidant medicament. The aim of the research was to study the lipid peroxidation under hypertension and stress by chemiluminescence. The experiment was conducted on male rats of the ISIAH line. The experiment consisted of 2 stages: stage of alarm and stage of chronic stress. We found that, depending on the type of stress, the state of the system lipid peroxidation-antioxidant protection differed. The role of stress in violation of the processes of lipoperoxidation in hypertension was established. The efficacy of the chemiluminescence method as an alternative to a complex of biochemical methods is shown. Express assessment of pro- and antioxidant status is possible for patients with hypertension.

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The Role of Lipid Peroxidation in the Myocardium in Stress and Antioxidant Protection of the Heart

Oxygen Radicals in the Pathophysiology of Heart Disease - Developments in Cardiovascular Medicine ◽

10.1007/978-1-4613-1743-2_19 ◽

1988 ◽

pp. 285-301

Author(s):

F. Z. Meerson

Keyword(s):

Lipid Peroxidation ◽

Antioxidant Protection

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Ischemic damage to the sarcoplasmic reticulum of skeletal muscles: The role of lipid peroxidation

Bulletin of Experimental Biology and Medicine ◽

10.1007/bf00798881 ◽

1977 ◽

Vol 83 (6) ◽

pp. 810-813 ◽

Cited By ~ 8

Author(s):

Yu. V. Arkhipenko ◽

M. V. Bilenko ◽

S. K. Dobrina ◽

V. E. Kagan ◽

Yu. P. Kozlov ◽

...

Keyword(s):

Lipid Peroxidation ◽

Sarcoplasmic Reticulum ◽

Skeletal Muscles ◽

Ischemic Damage

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The role of lipid peroxidation and antioxidant protection in skin in the development of experimental contact dermatitis

Journal of Education, Health and Sport ◽

10.12775/jehs.2020.10.12.006 ◽

2020 ◽

Vol 10 (12) ◽

pp. 56

Author(s):

M. M. Regeda-Furdychko

Keyword(s):

Lipid Peroxidation ◽

Contact Dermatitis ◽

Antioxidant Protection

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Features of antioxidant system in patients with obstructive jaundice of benign and malignant origin in dynamics

Kazan medical journal ◽

10.17816/kmj2018-919 ◽

2018 ◽

Vol 99 (6) ◽

pp. 919-923

Author(s):

N G Elmanova

Keyword(s):

Lipid Peroxidation ◽

Superoxide Dismutase ◽

Antioxidant Enzymes ◽

Antioxidant System ◽

Surgical Intervention ◽

Reduced Glutathione ◽

Malonic Dialdehyde ◽

Antioxidant Protection ◽

High Level

Aim. Study of the features of changes of antioxidant protection in patients with mechanical jaundice of benign and malignant origin in dynamics. Methods. The author studied the role of antioxidant system in the progression of mechanical jaundice of various origins in 104 patients. Groups of patients with a syndrome of mechanical jaundice of benign (62 patients) and malignant origin (42 patients) were isolated. The material of the study was blood from the ulnar vein, which was taken in the morning on an empty stomach before surgery. In the dynamics (on the 7th day after the operation), 53 patients were examined. To assess the state of antioxidant protection, a spectrophotometric method of investigation was used. Results. A high level of malonic dialdehyde, the product of lipid peroxidation, was determined in all patients regardless of origin. There was also a depression of the enzymatic link of antioxidant protection (a decrease in the activity of superoxide dismutase and catalase). After surgical intervention in patients with mechanical jaundice of benign origin, correction of the level of reduced glutathione was observed. In patients with mechanical jaundice of malignant origin in dynamics, the activity of antioxidant enzymes did not differ significantly from the norm (p1-3 = 0,23; p1-3 = 311). Conclusion. After surgical intervention, partial improvement of the condition of patients with mechanical jaundice of benign origin was observed, and dysfunction of antioxidant protection persisted in patients with mechanical jaundice of malignant origin.

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THE ROLE OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION FOR DEVELOPMENT PATHOGENESIS OF EXPERIMENTAL BRONCHIAL ASTHMA AND ADRENALINE MYOCARDIAL DAMAGE

Medical and Clinical Chemistry ◽

10.11603/mcch.2410-681x.2016.v0.i2.6673 ◽

2016 ◽

Author(s):

M. S. Reheda ◽

N. M. Nebelyuk M. Nebelyuk

Keyword(s):

Lipid Peroxidation ◽

Superoxide Dismutase ◽

Glutathione Reductase ◽

Bronchial Asthma ◽

Guinea Pigs ◽

Myocardial Damage ◽

Antioxidant Protection ◽

Diene Conjugates ◽

Lipid Peroxidation Products

The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the miocardium of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Analyses were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development of EA with AMD increased content of lipid peroxidation products (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the miocardium, followed by reduction in their on the 18th and 25th day.

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Antioxidant and prooxidant systems in patients with ischemic insult

Reviews on Clinical Pharmacology and Drug Therapy ◽

10.17816/rcf193281-290 ◽

2021 ◽

Vol 19 (3) ◽

pp. 281-290

Author(s):

Svetlana G. Belokoskova ◽

Sergey G. Tsikunov

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Ischemic Stroke ◽

Affective Disorders ◽

Ischemia Reperfusion ◽

Antioxidant Systems ◽

Antioxidant Protection ◽

Residual Symptoms ◽

Brain Functions

The literature review presents current information on the role of oxidative stress in the pathogenesis of cerebral ischemia / reperfusion. In patients with ischemic stroke, activation of enzymatic and non-enzymatic links of antioxidant defense in the form of an increase in the blood and cerebrospinal fluid of the activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, the content of glutathione reflects the presence of compensatory reserves, is a favorable factor for the restoration of brain functions. An increase in the content of markers of lipid peroxidation in various biological environments in patients with strokes, mainly malondialdehyde, even in combination with an increase in the content of markers of antioxidant protection, indicates its insufficiency and an unfavorable prognosis of the disease. An increase in the content of markers of lipid peroxidation, mainly malondialdehyde, in patients with strokes in various biological environments, even in combination with an increase content in markers of antioxidant protection, indicates its insufficiency, an unfavorable prognosis of the disease. The presence of affective disorders and the persistence of residual manifestations of ischemic stroke may be due to permanent oxidative stress. When choosing a therapy aimed at increasing the activity of antioxidant protection and reducing the toxic effect of prooxidants, one should take into account the severity and dynamics of metabolic disorders. In the presence of data reflecting insufficient activity of antioxidant systems in combination with increased activity of prooxidant systems, the appointment of drugs that reduce the severity of oxidative stress in the early stages of stroke is indicated. Therapy including antioxidant drugs is also indicated in patients with post-stroke affective disorders and with residual symptoms of stroke.

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The role of oxidative stress and antioxidant defence system in periodontitis

Medicinski casopis ◽

10.5937/mckg54-24883 ◽

2020 ◽

Vol 54 (2) ◽

pp. 75-82

Author(s):

Vesna Obradović

Keyword(s):

Oxidative Stress ◽

Lipid Peroxidation ◽

Periodontal Disease ◽

Inflammatory Process ◽

Molecular Mechanisms ◽

Signal Pathways ◽

Antioxidant Protection ◽

Oxidation Stress ◽

Antioxidant Defence System

The prevalence of periodontal disease is very high in the adult population. According to research results, as much as 46% of the total population was affected by periodontal disease in the period from 2010 to 2012, which would mean that 64.7 million people had periodontitis, of which 8% had a severe form of this disease. Having in mind the clinical and socioeconomic significance of periodontitis, this review aims to present in a comprehensive way the pathogenetic aspects of periodontitis with a special emphasis on oxidative stress and antioxidant protection mechanisms as possible molecular mechanisms for the development of periodontitis in adults. Oxidation stress is involved in the progression of periodontitis as a chronic inflammatory disease of periodontium, which occurs as a result of imbalance between host response and bacterial infection. At the same time there is a decreased antioxidant activity and salivary gland capacity, which contributes to the further development of this disease. MDA is the most common lipid peroxidation derivative that occurs in periodontitis. All of the mentioned literature data suggest that the elevated MDA values may be due to both local and systemic oxidative stress as a response to inflammatory periodontal disease alone or in combination with other systemic disorders and smoking. The harmful effects of ROS during oxidative stress occur through lipid peroxidation processes and irreversible protein modification to cell apoptosis and programmed cell death. In addition to the two most important signal pathways, caspase pathway and NADPH oxidase-4 pathway, several other signaling pathways mediate in oxidative cell damage: PERK/NRF2 signal path, JNK / mitogen-activating pathway (MAP). When a clinically visible inflammatory process occurs in periodontium, this usually presents a condition that is more or less irreversible. In parodontology, therefore, the idea of introducing biochemical analyzes to diagnose the inflammatory process in parodontium is still open before it can be seen at the clinical level. For this reason, the significance of the role of oxidative stress, the antioxidant protection of the organism and the molecular mechanisms by which damage occurs is an indisputable importance. Assessment and measurement of biomarkers of oxidative stress and antioxidant enzymes can play a central role in monitoring biochemical indicators of parodontium state and even assist with various methods of treatment of periodontal disease.

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