scholarly journals Features of antioxidant system in patients with obstructive jaundice of benign and malignant origin in dynamics

2018 ◽  
Vol 99 (6) ◽  
pp. 919-923
Author(s):  
N G Elmanova
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Antioxidant System ◽  
Surgical Intervention ◽  
Reduced Glutathione ◽  
Malonic Dialdehyde ◽  
Antioxidant Protection ◽  
High Level

Aim. Study of the features of changes of antioxidant protection in patients with mechanical jaundice of benign and malignant origin in dynamics. Methods. The author studied the role of antioxidant system in the progression of mechanical jaundice of various origins in 104 patients. Groups of patients with a syndrome of mechanical jaundice of benign (62 patients) and malignant origin (42 patients) were isolated. The material of the study was blood from the ulnar vein, which was taken in the morning on an empty stomach before surgery. In the dynamics (on the 7th day after the operation), 53 patients were examined. To assess the state of antioxidant protection, a spectrophotometric method of investigation was used. Results. A high level of malonic dialdehyde, the product of lipid peroxidation, was determined in all patients regardless of origin. There was also a depression of the enzymatic link of antioxidant protection (a decrease in the activity of superoxide dismutase and catalase). After surgical intervention in patients with mechanical jaundice of benign origin, correction of the level of reduced glutathione was observed. In patients with mechanical jaundice of malignant origin in dynamics, the activity of antioxidant enzymes did not differ significantly from the norm (p1-3 = 0,23; p1-3 = 311). Conclusion. After surgical intervention, partial improvement of the condition of patients with mechanical jaundice of benign origin was observed, and dysfunction of antioxidant protection persisted in patients with mechanical jaundice of malignant origin.

scholarly journals CONDITION OF LIPID PEROXIDE OXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS

2018 ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Blood Plasma ◽  
Glutathione Reductase ◽  
Antioxidant System ◽  
Infectious Mononucleosis ◽  
Malonic Dialdehyde

The indicators of the activity of lipid peroxidation and the antioxidant system were studied in dynamics in 158 patients with infectious mononucleosis depending on the severity of the clinical course of the disease. It is proved that lipid peroxidation is significantly activated in patients with infectious mononucleosis as the severity of the disease increases and therefore increases the oxidative activity of blood plasma, the concentration of dyne conjugates and malondialdehyde in the blood, decreases the activity of antioxidant enzymes of erythrocytes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase), glutathione peroxidase and glutathione reductase activity in plasma and lowering the concentration of total and reduced glutathione in the blood, as well as reduce the antioxidant activity of blood plasma and erythrocytes. Lipid peroxidation significantly increase and the activity of the antioxidant system decrease in patients with infectious mononucleosis in the acute period of the disease, as evidenced by the increased concentration of dyne conjugates, malonic dialdehyde and total oxidative plasma activity in the blood, reduced activity of the total antioxidant activity of plasma and erythrocytes, the decrease in the activity of antioxidant enzymes of erythrocytes catalase, superoxide dismutase, glutathione peroxidase, glutathione peroxidase and glutathione reductase of blood plasma, the decrease in the concentration of glutathione in the blood. The most pronounced disorders of lipid peroxidation and antioxidant system activity were found in patients with moderate-severe and severe infectious mononucleosis. The development of cytolytic syndrome in infectious mononucleosis is associated with the action of reactive oxygen forms species and lipid hydroperoxide.

Interaction of Pro- and Antioxidant Factors, Nitric Oxide Metabolites in Blood and Gingival Tissues during Experimental Chronic Gastritis and Duodenitis

2016 ◽  
Vol 28 ◽  
pp. 85-88
Author(s):  
Y.G. Romanenko
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Blood Plasma ◽  
Malonic Dialdehyde ◽  
Gingival Tissue ◽  
Antioxidant Protection ◽  
Leading Role ◽  
Protein Molecules ◽  
Nitric Oxide Metabolites

The stable metabolites rate of nitric oxide is reduced three times compared with the rate in the group of control animals in homogenates of rats’ gingival tissue with gastritis and duodenitis. Increasing of the catalase rate with simultaneous increasing of lipids and proteins oxidation was accompanied by decreasing activity of superoxide dismutase. Decreasing of the malonic dialdehyde content and indices protein molecules fragmentation in the blood plasma with simultaneous increasing of catalase and nitric oxide metabolites levels indicates the leading role of nitric oxide in antioxidant protection of the organism in conditions of disease.

scholarly journals The Role of Antioxidant to Prevent Free Radicals in The Body

Sains Medika ◽  
2017 ◽  
Vol 8 (1) ◽  
pp. 39 ◽  
Author(s):  
Siti Thomas Zulaikhah
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Free Radicals ◽  
Negative Impact ◽  
Reduced Glutathione ◽  
The Body ◽  
Enzyme Superoxide Dismutase ◽  
Vegetables And Fruits ◽  
Β Carotene

AbstractAntioxidants are compounds that can counteract or reduce the negative impact oxidants in the body. Antioxidants work by donating an electron to compounds that are oxidant so that the oxidant compound activity can be inhibited. Antioxidants are classified into two, namely antioxidant enzymes and non-enzyme. Antioxidant enzymes as enzyme superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), a non-enzyme antioxidant found in many vegetables and fruits, which include reduced glutathione (GSH), vitamin C, E, β- carotene, flavonoids, isoflavones, flavones, antosionin, catechins, and isokatekin, and lipoic acid. Low antioxidant enzymes can be used as a marker of high levels of free radicals in the body. Following review aims to provide an overview of the role of antioxidants in preventing the formation of free radicals in the body.

scholarly journals EFFECT OF PEPTIDES ON ANTIOXIDANT SYSTEM ENZYMES IN RATS WITH HEAVY METALS, PHOSPHOORGANIC PESTICIDES INTOXICATION

2016 ◽  
Author(s):  
Ye. B. Dmukhalska ◽  
Ya. I. Honskyi
Keyword(s):  
Heavy Metals ◽  
Lipid Peroxidation ◽  
Heavy Metal ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Metal Ions ◽  
Antioxidative Enzymes ◽  
Heavy Metal Ions ◽  
Antioxidant Protection

The aim of this work was to examine the effect of heavy metal ions and phosphororganic pestecies which contain glyphosate on activity antioxidative enzymes in the serum and liver of rats. The effect of peptide tsysteil-histidiltyrosilhistidil-isoleucine on the state of antioxidant protection (superoxide dismutase, catalase) and lipid peroxidation was reached. The peptide exhibits antioxidant activity, the correction of the peptide increases antioxidant enzymes activity and concentration of glutathione.

scholarly journals Antioxidant system of rats with heavy metals and phospoorganic pesticides intoxication and peptides applying

2015 ◽  
Vol 17 (3) ◽  
Author(s):  
Ye. B. Dmukhalska ◽  
Ya. I. Honsky
Keyword(s):  
Heavy Metals ◽  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Antioxidant Enzymes ◽  
Free Radical ◽  
Antioxidant System ◽  
The State ◽  
Antioxidant Protection ◽  
Free Radical Processes ◽  
Radical Processes

<p>The effect of peptide tsysteil-histidil-tyrosil-histidil-isoleucine on the state of antioxidant protection (superoxide<br />dismutase, catalase) and lipid peroxidation has been reached. The peptide exhibits antioxidant activity, the correction<br />of the peptide reduces free radical processes and decreases the products of lipid peroxidation and increases<br />antioxidant enzymes activity.</p>

Protective effect of curcumin against lead neurotoxicity in rat

2003 ◽  
Vol 22 (12) ◽  
pp. 653-658 ◽  
Author(s):  
Pradeep K Shukla ◽  
Vinay K Khanna ◽  
Mohd Y Khan ◽  
Rikhab C Srimal
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Protective Effect ◽  
Corpus Striatum ◽  
Reduced Glutathione ◽  
Antioxidant Property ◽  
Brain Regions ◽  
Lead Levels ◽  
The Brain

Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.

scholarly journals Influence of cadmium loading on the state of the antioxidant system in the organism of bulls

2016 ◽  
Vol 24 (1) ◽  
pp. 96-102 ◽  
Author(s):  
B. V. Gutyj ◽  
S. D. Mursjka ◽  
D. F. Hufrij ◽  
I. I. Hariv ◽  
N. D. Levkivska ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Antioxidant System ◽  
Cadmium Chloride ◽  
Antioxidant Defense ◽  
Reduced Glutathione ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Young Cattle

This article presents the results of research on the influence of cadmium loading on the state level of enzymatic and non-enzymatic antioxidant links of the antioxidant defense system of the organisms of young cattle, such as the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels, selenium, vitamins A and E. It was found that feeding bull calves with cadmium chloride at doses of 0.03 and 0.05 mg/kg of body weight helped to reduce both the enzymatic and non-enzymatic link of antioxidant protection (superoxide dismutase 31%, catalase 13%, glutathione peroxidase 23%, reduced glutathione 10%, vitamin A 28%, vitamin E 31%, selenium 20%). Toxic effects of cadmium promotes change in steady-state concentrations of radical metabolites О2–,ОН˙, НО2˙, which, in turn, trigger the process of lipid peroxidation. The lowest level of indicators of antioxidant defense system in the blood of young cattle was registered on the sixteenth and twenty-fourth days of the experiment, which is associated with increased activation of lipid peroxidation and the disturbaance of the balance between the antioxidant system and lipid peroxidation intensity. The activity of the antioxidant defense system in the blood was different for calves fed with cadmium chloride at doses of 0.03 and 0.05 mg/kg of animal mass. The more cadmium chloride in the feed, the lower the activity of the antioxidant defense system of the calves’ organisms was registered. Thus cadmium chloride depresses the antioxidant defense system, which specifically involves lowering the activity of enzymatic links (catalase, superoxide dismutase, glutathione peroxidase) and non-enzymatic links (reduced glutathione, selenium, vitamins A and E).

scholarly journals Порушення процесів вільнорадикального окиснення і антиоксидантного захисту в печінці при експериментальному алергічному альвеоліті та їх корекція тіотриазоліном

2015 ◽  
Author(s):  
М. А Пасічник
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Enzyme Activity ◽  
Malonic Dialdehyde ◽  
Free Radical Oxidation ◽  
Antioxidant Protection ◽  
Allergic Alveolitis ◽  
Radical Oxidation ◽  
Peroxidase Oxidation ◽  
Experimental Allergic

ПОРУШЕННЯ ПРОЦЕСІВ ВІЛЬНОРАДИКАЛЬНОГО ОКИСНЕННЯ І АНТИОКСИДАНТНОГО ЗАХИСТУ В ПЕЧІНЦІ ПРИ ЕКСПЕРИМЕНТАЛЬНОМУ АЛЕРГІЧНОМУ АЛЬВЕОЛІТІ ТА ЇХ КОРЕКЦІЯ ТІОТРИАЗОЛІНОМ - У роботі показано, що експериментальний алергічний альвеоліт характеризується зростанням вмісту продуктів ліпопероксидаціі (дієнових кон’югатів і малонового діальдегіду) у всі періоди дослідження та активності ферментів супероксиддисмутази (СОД), каталази (КТ) і пероксидази (ПО) на 14 добу експерименту і суттєве зниження показників СОД, КТ і ПО на 34 і 44 доби цього модельного процесу захворювання та корегуючий вплив тіотриазоліну на дані показники.<br />НАРУШЕНИЕ ПРОЦЕССОВ СВОБОДНОРАДИКАЛЬНОГО ОКИСЛЕНИЯ И АНТИОКСИДАНТНОЙ ЗАЩИТЫ В ПЕЧЕНИ ПРИ ЭКСПЕРИМЕНТАЛЬНОМ АЛЛЕРГИЧЕСКОМ АЛЬВЕОЛИТЕ И КОРРЕКЦИЯ ИХТИОТРИАЗОЛИНОМ - В работе показано, что экспериментальный аллергический альвеолит характеризуется возростанием содержания продуктов липопероксидации (диеновых коньюгатов и малонового диальдегида) в печени во все периоды исследования и активности ферментов су- пероксиддисмутазы (СОД), каталазы (КТ) и пероксидазы (ПО), особенно на 14 сутки эксперимента и существенное снижение показателей СОД, КТ и ПО на 34 и 44 сутки этого модельного процесса заболевания и корригирующее влияние тио- триазолина на эти показатели.<br />DISTRUBANCES OF THE PROCESSES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN LIVER AT EXPERIMENTAL ALLERGIC ALVEOLITIS AND THEIR CORRECTION WITH THIOTRIAZOLIN - The paper shows that experimental allergic alveolitis is characterized by increase of content of lipid peroxidation products (dienic conjugates and malonic dialdehyde) in all periods of study and enzyme activity of superoxide dismutase (SOD), catalase (CT) and peroxidase (PO) on the 14th day of the experiment and significant decrease of SOD, CT and PO on 34th and 44th days of this model process of disease and corrective influence of thiotriazolin on these indicators.<br />Ключові слова: пероксидне окиснення ліпідів, антиоксидантна система, тіотриазолін.<br />Ключевые слова: пероксидное окисление липидов, антиоксидантная система, тиотриазолин.<br />Key words: peroxidase oxidation of iipids, antioxidant system, thiotriazoiin.

scholarly journals THE ROLE OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION FOR DEVELOPMENT PATHOGENESIS OF EXPERIMENTAL BRONCHIAL ASTHMA AND ADRENALINE MYOCARDIAL DAMAGE

2016 ◽  
Author(s):  
M. S. Reheda ◽  
N. M. Nebelyuk M. Nebelyuk
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Reductase ◽  
Bronchial Asthma ◽  
Guinea Pigs ◽  
Myocardial Damage ◽  
Antioxidant Protection ◽  
Diene Conjugates ◽  
Lipid Peroxidation Products

The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the miocardium of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Analyses were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development of EA with AMD increased content of lipid peroxidation products (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the miocardium, followed by reduction in their on the 18th and 25th day.

scholarly journals Lipid Peroxides and Antioxidant Enzymes in Cisplatin-Induced Chronic Nephrotoxicity in Rats

2005 ◽  
Vol 2005 (3) ◽  
pp. 139-143 ◽  
Author(s):  
Ricardo González ◽  
Cheyla Romay ◽  
Aluet Borrego ◽  
Frank Hernández ◽  
Nelson Merino ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Antioxidant System ◽  
Renal Damage ◽  
Lipid Peroxides ◽  
Thiobarbituric Acid ◽  
Thiobarbituric Acid Reactive Substances ◽  
Repeated Doses

Cisplatin (CDDP), an anticancer drug, induces remarkable toxicity in the kidneys of animals and humans and it has been well documented that reactive oxygen species and the renal antioxidant system are strongly involved in acute renal damage induced by CDDP. The aim of the present study was to investigate whether or not the renal antioxidant system plays also an important role in chronic renal damage induced by repeated doses of CDDP (1 mg/kg intraperitoneally twice weekly during 10 weeks in rats). In order to elucidate it, serum creatinine and urea levels, renal glutathione and thiobarbituric acid-reactive substances (TBARS) content, as well as renal superoxide dismutase and glutathione peroxidase activities were measured in the kidney homogenates of chronically CDDP-treated rats and additionally histological studies were performed in the rat kidneys. The chronic treatment with CDDP induced a significant increase in creatinine and urea levels in serum, but the other parameters mentioned above were not significantly modified as compared to the values in nontreated rats. Taking into account these results, we conclude that chronic CDDP administration induces also severe nephrotoxicity, in contrast to CDDP acute application, without any significant modification in the activity of relevant antioxidant enzymes such as superoxide dismutase and glutathione peroxidase, renal glutathione and lipid peroxides, by which the role of the antioxidant system in chronic nephrotoxicity induced by CDDP in rats is uncertain.

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