Modulation of human neutrophil and monocyte oxidative burst byLegionella pneumophila sonic extract

1987 ◽  
Vol 6 (6) ◽  
pp. 646-652 ◽  
Author(s):  
C. Rechnitzer ◽  
A. Kharazmi ◽  
H. Nielsen ◽  
L. Baek
Keyword(s):  
Oxidative Burst ◽  
Human Neutrophil

scholarly journals Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal Pathogen Curvularia lunata

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 235
Author(s):  
Eszter Judit Tóth ◽  
Mónika Varga ◽  
Miklós Takó ◽  
Mónika Homa ◽  
Olivér Jáger ◽  
...  
Keyword(s):  
Oxidative Burst ◽  
Human Neutrophil ◽  
Fungal Pathogen ◽  
Fungal Infections ◽  
Neutrophil Function ◽  
Neutrophil Extracellular Trap ◽  
Curvularia Lunata ◽  
Neutrophil Granulocytes ◽  
Infectious Agents ◽  
First Line

Curvularia lunata is an ascomycete filamentous fungus causing local and invasive phaeohyphomycoses in both immunocompromised and immunocompetent patients. Neutrophils are crucial participants of the first line host defense against fungal infections. They migrate to the infected site and eliminate the infectious agents by various mechanisms including phagocytoses, oxidative damage, or formation of neutrophil extracellular trap (NET). Neutropenia may be a risk factor for phaeohyphomycoses, and restoration of the neutrophil function can improve the outcome of the infection. In the present study, interaction of primary human neutrophil granulocytes with the hyphae C. lunata was examined and compared to that with the well characterized filamentous fungal pathogen Aspergillus fumigatus. Neutrophils could recognize the serum opsonized hyphae of C. lunata and attach to them. Myeloperoxidase release was also activated by a soluble factor present in the culture supernatant of the fungus. Induction of the oxidative burst was found to depend on serum opsonization of the hyphae. Although extracellular hydrogen peroxide production was induced, the fungus efficiently blocked the oxidative burst by acidifying the reaction environment. This blockage also affected the NET forming ability of the neutrophils.

Gender-Related Variations and Interaction of Human Neutrophil Cyclooxygenase and Oxidative Burst Metabolites

1986 ◽  
Vol 40 (2) ◽  
pp. 133-146 ◽  
Author(s):  
Susan R. Mallery ◽  
Barbara J. Zeligs ◽  
Peter W. Ramwell ◽  
Joseph A. Bellanti
Keyword(s):  
Oxidative Burst ◽  
Human Neutrophil

Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity

1998 ◽  
Vol 63 (2) ◽  
pp. 216-224 ◽  
Author(s):  
P. K. Narayanan ◽  
W. O. Carter ◽  
P. E. Ganey ◽  
R. A. Roth ◽  
S. L. Voytik-Harbin ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Polychlorinated Biphenyls ◽  
Oxidative Burst ◽  
Human Neutrophil ◽  
Superoxide Dismutase Activity ◽  
Neutrophil Oxidative Burst

scholarly journals Immune Complexes Isolated from Patients with Pulmonary Tuberculosis Modulate the Activation and Function of Normal Granulocytes

2012 ◽  
Vol 19 (12) ◽  
pp. 1965-1971 ◽  
Author(s):  
P. Senbagavalli ◽  
J. Nancy Hilda ◽  
V. D. Ramanathan ◽  
V. Kumaraswami ◽  
Thomas B. Nutman ◽  
...  
Keyword(s):  
Immune Response ◽  
Pulmonary Tuberculosis ◽  
Intracellular Calcium ◽  
Immune Complexes ◽  
Oxidative Burst ◽  
Human Neutrophil ◽  
Platelet Activating Factor ◽  
The Other ◽  
And Function ◽  
Granulocyte Function

ABSTRACTCirculating immune complexes (ICs) are associated with the pathogenesis of several diseases. Very little is known about the effect of ICs on the host immune response in patients with tuberculosis (TB). The effects of ICs isolated from patients with TB in modulating the release of calcium, cytokines, and granular proteins were studied in normal granulocytes, as were their chemotactic, phagocytic, and oxidative burst processes. ICs from TB patients induced decreased production of cytokines and platelet-activating factor (PAF) from normal granulocytes. ICs from TB patients also induced enhanced chemotaxis and phagocytosis but caused diminished oxidative burst. This was accompanied by an increased release in intracellular calcium. On the other hand, ICs from TB patients induced increased release of the granular proteins human neutrophil peptides 1 to 3 (HNP1–3). Thus, ICs from patients with TB exhibit a profound effect on granulocyte function with activation of certain effector mechanisms and dampening of others.

Modulation of human complement activation and the human neutrophil oxidative burst by different root extracts ofPicrorhiza kurroa

1990 ◽  
Vol 4 (6) ◽  
pp. 207-211 ◽  
Author(s):  
J. M. Simons ◽  
L. A. T. Hart ◽  
R. P. Labadie ◽  
H. van Dijk ◽  
K. T. D. de Silva
Keyword(s):  
Complement Activation ◽  
Oxidative Burst ◽  
Human Neutrophil ◽  
Human Complement ◽  
Root Extracts ◽  
Neutrophil Oxidative Burst

scholarly journals Helicobacter felisdoes not stimulate human neutrophil oxidative burst in contrast to ‘Gastrospirillum hominis’ andHelicobacter pylori

2001 ◽  
Vol 30 (3) ◽  
pp. 187-195 ◽  
Author(s):  
Tina Ken Hansen ◽  
Per Syrak Hansen ◽  
Annette Nørgaard ◽  
Henrik Nielsen ◽  
Adrian Lee ◽  
...  
Keyword(s):  
Oxidative Burst ◽  
Human Neutrophil ◽  
Gastrospirillum Hominis ◽  
Neutrophil Oxidative Burst
Sign in / Sign up

Export Citation Format

Share Document