Publication rate as a function of laboratory size in three biomedical research institutions

1981 ◽  
Vol 3 (6) ◽  
pp. 467-487 ◽  
Author(s):  
J. E. Cohen
Author(s):  
Josephine Johnston ◽  
Naomi Scheinerman

This chapter reviews the two main concerns about financial relationships with industry: that they could conflict with research-related obligations leading to biased or flawed research and an incomplete research record, and that they could undermine trust in biomedical research, researchers, and research institutions. We show that these concerns are valid, and that they persist in the U.S., despite a gradual tightening over the past decade of rules and regulations regarding financial conflicts of interest in biomedical research. The threat that financial interests can pose to research integrity should be of special interest to psychiatry for two reasons: they are prevalent in this field, and they pose heightened risks due to the nature of psychiatry itself. Finally, we recommend that psychiatry—and individual research psychiatrists—take more seriously the threat posed by financial relationships with industry, and work together to develop additional strategies for avoiding and managing financial conflicts of interest.


eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Henry R Bourne

Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.


Author(s):  
Corinna Klingler ◽  
Magdaléna von Jagwitz-Biegnitz ◽  
Ronny Baber ◽  
Karl-Friedrich Becker ◽  
Edgar Dahl ◽  
...  

AbstractBiobanks are important infrastructures facilitating biomedical research. After a decade of rolling out such infrastructures, a shift in attention to the sustainability of biobanks could be observed in recent years. In this regard, an increase in the as yet relatively low utilisation rates of biobanks has been formulated as a goal. Higher utilisation rates can only be achieved if the perspectives of potential users of biobanks—particularly researchers not yet collaborating with biobanks—are adequately considered. To better understand their perspectives, a survey was conducted at ten different research institutions in Germany hosting a centralised biobank. The survey targeted potential users of biobank services, i.e. researchers working with biosamples. It addressed the general demand for biosamples, strategies for biosample acquisition/storage and reasons for/against collaborating with biobanks. In total, 354 researchers filled out the survey. Most interestingly, only a minority of researchers (12%) acquired their biosamples via biobanks. Of the respondents not collaborating with biobanks on sample acquisition, around half were not aware of the (services of the) respective local biobank. Those who actively decided against acquiring biosamples via a biobank provided different reasons. Most commonly, respondents stated that the biosamples required were not available, the costs were too high and information about the available biosamples was not readily accessible. Biobanks can draw many lessons from the results of the survey. Particularly, external communication and outreach should be improved. Additionally, biobanks might have to reassess whether their particular collection strategies are adequately aligned with local researchers’ needs.


2018 ◽  
Vol 2 (5) ◽  
pp. 305-311
Author(s):  
Adrienne Zell ◽  
Lindsey Smith ◽  
N. David Yanez ◽  
Jeanne-Marie Guise ◽  
Ryan Pelkey ◽  
...  

AbstractIntroductionThere is growing concern about the declining physician-scientist workforce. NIH recently provided a national dashboard describing the biomedical research workforce, but local strategies are needed.MethodsWe used curated local and national data to develop a workforce dashboard.ResultsMany trends at Oregon Health & Science University (OHSU) were similar to those nationally, such as the increasing percentage of Research Project Grant (RPG)-holding PhDs and the aging RPG population, but differences were also apparent. At OHSU, nearly ¾ of physician-scientist RPGs hold MD-only, compared with nationally, where nearly half are MD/PhD. OHSU also lags in the percentage of RPGs held by women physician-scientists.ConclusionsOur analysis also permitted us to gain a more complete picture of research funding that has been done nationally. We used these data to develop a dashboard that allows our institution to develop policies to increase the numbers of physician-scientists. The data generation approaches and dashboard are likely to be useful at other institutions, as well.


Author(s):  
Arno Simons ◽  
Barbara Hendriks ◽  
Martin Reinhart ◽  
Faten Ahmed

Abstract While translational research (TR) aims at changing regulatory and organizational practices in the biomedical field, surprisingly little is known about how practitioners in the lab or the clinic think about translation. Addressing this gap, we present results from a Q-methodological study on the meanings and values associated with translation held by researchers, clinicians, and clinician scientists at two major German biomedical research institutions implementing TR strategies. We identify eight different collective understandings of translation, with respect to both where primary translational problems are located and what the most immediate and effective measures should be. Our findings suggest that there may not be a one-fits-all solution for improving translation and that general regulatory and organizational measures may be less effective than measures addressing specific audiences and their specific viewpoints. TR does, however, work well as an umbrella term in stimulating and orchestrating a productive interaction between various viewpoints, practices, and contexts.


2019 ◽  
Author(s):  
Arno Simons ◽  
Barbara Hendriks ◽  
Martin Reinhart ◽  
Faten Ahmed

Given that translational research (TR) aims at changing regulatory and organizational practices in the biomedical field, surprisingly little is known about how those who are actually supposed to practice translation in the lab or the clinic think about it. Addressing this gap, we present results from a q-methodological study on the meanings and values associated with translation held by researchers and clinicians at two major German biomedical research institutions implementing TR strategies. We identify eight different collective understandings of translation in practice, with respect to both where primary translational problems are located and what the most immediate and effective measures should be. Our findings suggest that there may not be a one-fits-all solution for improving translation and that general regulatory and organizational measures may be less effective than measures addressing specific audiences and their specific viewpoints.


eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Michael D Schaller ◽  
Gary McDowell ◽  
André Porter ◽  
Dorothy Shippen ◽  
Katherine L Friedman ◽  
...  

Numerous concerns have been raised about the sustainability of the biomedical research enterprise in the United States. Improving the postdoctoral training experience is seen as a priority in addressing these concerns, but even identifying who the postdocs are is made difficult by the multitude of different job titles they can carry. Here, we summarize the detrimental effects that current employment structures have on training, compensation and benefits for postdocs, and argue that academic research institutions should standardize the categorization and treatment of postdocs. We also present brief case studies of two institutions that have addressed these challenges and can provide models for other institutions attempting to enhance their postdoctoral workforces and improve the sustainability of the biomedical research enterprise.


Author(s):  
T. L. Hayes

Biomedical applications of the scanning electron microscope (SEM) have increased in number quite rapidly over the last several years. Studies have been made of cells, whole mount tissue, sectioned tissue, particles, human chromosomes, microorganisms, dental enamel and skeletal material. Many of the advantages of using this instrument for such investigations come from its ability to produce images that are high in information content. Information about the chemical make-up of the specimen, its electrical properties and its three dimensional architecture all may be represented in such images. Since the biological system is distinctive in its chemistry and often spatially scaled to the resolving power of the SEM, these images are particularly useful in biomedical research.In any form of microscopy there are two parameters that together determine the usefulness of the image. One parameter is the size of the volume being studied or resolving power of the instrument and the other is the amount of information about this volume that is displayed in the image. Both parameters are important in describing the performance of a microscope. The light microscope image, for example, is rich in information content (chemical, spatial, living specimen, etc.) but is very limited in resolving power.


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