scholarly journals A recipe for mediocrity and disaster, in five axioms

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Henry R Bourne

Biomedical research in the US will become unsustainable unless scientists and research institutions start to question certain assumptions they have long taken for granted.

2020 ◽  
Vol 6 (Supplement_1) ◽  
pp. 56-56
Author(s):  
Vidya Vedham ◽  
Marianne K. Henderson ◽  
Osvaldo Podhajcer ◽  
Andrea Llera ◽  
Marisa Dreyer Breitenbach ◽  
...  

PURPOSE The National Cancer Institute (NCI) Center for Global Health promotes global oncology research to reduce cancer burden worldwide. In 2009, NCI launched the Latin American Cancer Research Network (LACRN) to support a clinical cancer research network in Latin America. LACRN was started by a coalition of research institutions through bilateral collaborative agreements between the US Department of Health and Human Services and the governments of Argentina, Brazil, Chile, Mexico, and Uruguay. The LACRN is supported through a research contract to a study coordination center and subcontracts to 6 low- and middle-income country sites. The participating countries have a shared goal that meets the specific research needs of the regions. The overarching purpose of this endeavor is to implement high-quality standards for conducting clinical research studies and developing collaborative cancer research projects. METHODS NCI supported a clinical breast cancer project for LACRN, “Molecular profiling of breast cancer (MPBC) in Latin American women with stage II and III breast cancer receiving standard neo-adjuvant chemotherapy.” The molecular profiling of breast cancer study was conducted in 40 hospitals and research institutions across 5 countries with a study population of approximately 1,400 patients. RESULTS AND CONCLUSION Establishing a comprehensive network in Latin America and their research institutions yielded an incredible research resource that can be used in future studies, driven by the network. Throughout the process of developing and implementing studies, LACRN helped identify key elements of the functionality of research networks, such as the pivotal role of institutional and government commitment for sustainability; the importance of building multidisciplinary teams, transparent communications, and training; the ability to combine translational, epidemiology, and clinical research to close research gaps; and the application of new technologies to standard cancer clinical care.


2015 ◽  
Vol 112 (35) ◽  
pp. 10832-10836 ◽  
Author(s):  
Christopher L. Pickett ◽  
Benjamin W. Corb ◽  
C. Robert Matthews ◽  
Wesley I. Sundquist ◽  
Jeremy M. Berg

The US research enterprise is under significant strain due to stagnant funding, an expanding workforce, and complex regulations that increase costs and slow the pace of research. In response, a number of groups have analyzed the problems and offered recommendations for resolving these issues. However, many of these recommendations lacked follow-up implementation, allowing the damage of stagnant funding and outdated policies to persist. Here, we analyze nine reports published since the beginning of 2012 and consolidate over 250 suggestions into eight consensus recommendations made by the majority of the reports. We then propose how to implement these consensus recommendations, and we identify critical issues, such as improving workforce diversity and stakeholder interactions, on which the community has yet to achieve consensus.


Author(s):  
Josephine Johnston ◽  
Naomi Scheinerman

This chapter reviews the two main concerns about financial relationships with industry: that they could conflict with research-related obligations leading to biased or flawed research and an incomplete research record, and that they could undermine trust in biomedical research, researchers, and research institutions. We show that these concerns are valid, and that they persist in the U.S., despite a gradual tightening over the past decade of rules and regulations regarding financial conflicts of interest in biomedical research. The threat that financial interests can pose to research integrity should be of special interest to psychiatry for two reasons: they are prevalent in this field, and they pose heightened risks due to the nature of psychiatry itself. Finally, we recommend that psychiatry—and individual research psychiatrists—take more seriously the threat posed by financial relationships with industry, and work together to develop additional strategies for avoiding and managing financial conflicts of interest.


F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 229
Author(s):  
Nick Riddiford

Background: Recent articles have presented a bleak view of career prospects in biomedical research in the US. Too many PhDs and postdocs are trained for too few research positions, creating a “holding-tank” of experienced senior postdocs who are unable to get a permanent position. Coupled with relatively low salaries and high levels of pressure to publish in top-tier academic journals, this has created a toxic environment that is perhaps responsible for a recently observed decline in biomedical postdocs in the US, the so-called “postdocalypse”. Methods: To address the gulf of information relating to working habits and attitudes of UK-based academic biomedical researchers, a link to an online survey was included in an article published in the Guardian newspaper. Survey data were collected between 21st March 2016 and 6th November 2016 and analysed to examine discrete profiles for three major career stages: PhD, postdoc and principal investigator. Results: Overall, the data presented here echo trends observed in the US: The 520 UK-based biomedical researchers responding to the survey reported feeling disillusioned with academic research, due to the low chance of getting a permanent position and the long hours required at the bench. Also like the US, large numbers of researchers at each distinct career stage are considering leaving biomedical research altogether. Conclusions: There are several systemic flaws in the academic scientific research machine – for example the continual overproduction of PhDs and the lack of stability in the early-mid stages of a research career - that are slowly being addressed in countries such as the US and Germany. These data suggest that similar flaws also exist in the UK, with a large proportion of respondents concerned about their future in research. To avoid lasting damage to the biomedical research agenda in the UK, addressing such concerns should be a major priority.


2002 ◽  
Vol 06 (09) ◽  
pp. 332-338

New Biotech Center in South Australia. China Sees Jump in AIDS Cases. World First Liver Operation Succeeds in Hong Kong. India Sets Grain Export Target. Increasing Rate of Eating Disorders in Japanese Teenagers. Japan Urged to Unite Nanotechnology with Biotechnology. Spying Controversies Surround Korea's Biotech Hub in the US. Korea Latest Biotech Efforts. Korea to Set up Bioterror Hotline. Technology Showcase for New Zealand and Australia Biotech Sectors. Singapore Gives US$33 Million Grant for Biomedical Research. Singapore to Build Second Science Hub. Students Awarded for Outstanding Scientific Research.


2014 ◽  
Vol 43 (2) ◽  
pp. 47-64
Author(s):  
Josef Gregory Mahoney

This paper discusses how cooperation between Chinese researchers and their foreign counterparts has changed. The paper draws on current literature and the author's experience as a researcher in the US and in China, arguing that while cooperation has increased overall, it has done so in ways that have crowded out old forms of cooperation or made them passé. The paper focuses particularly on how changes at leading Chinese research institutions have impacted international cooperation, both positively and negatively, and suggests ways in which foreign scholars might effectively pursue new avenues for cooperation and exchange.


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