The relative infrequency and low levels of neutralising and immunoprecipitating antibody to herpes simplex viruses types 1 and 2 in patients with a history of recurrent herpes genitalis

1983 ◽  
Vol 171 (4) ◽  
pp. 243-250 ◽  
Author(s):  
C. B. J. Woodman ◽  
D. Stocker ◽  
D. Sugrue ◽  
M. Desberbasques ◽  
C. E. Hartley ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Herpes Genitalis ◽  
Herpes Simplex Viruses ◽  
Recurrent Herpes ◽  
History Of ◽  
Low Levels

Herpes Simplex Encephalitis Occurring After Chemotherapy, Surgery, and Stereotactic Radiotherapy for Medulloblastoma

2000 ◽  
Vol 124 (12) ◽  
pp. 1809-1812
Author(s):  
S. Molloy ◽  
D. Allcutt ◽  
P. Brennan ◽  
M. A. Farrell ◽  
R. Perryman ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Herpes Simplex Encephalitis ◽  
Surgical Removal ◽  
Formalin Fixed Paraffin ◽  
Recurrent Herpes ◽  
Formalin Fixed Paraffin Embedded ◽  
History Of ◽  
Cerebellar Medulloblastoma ◽  
Simplex Virus ◽  
Inflammatory Changes

Abstract Reactivation of latent herpes simplex virus (HSV) in the trigeminal ganglion most commonly gives rise to recurrent herpes labialis and rarely to herpes simplex encephalitis. The mechanisms underlying reactivation of latent trigeminal HSV are complex. Here we report the case history of a 25-year-old woman who developed a fatal, bilateral necrotizing destructive temporal lobe lesion following surgical removal of a cerebellar medulloblastoma and combined radiotherapy and chemotherapy for recurrent tumor. Neuropathologic examination of the brain revealed minimal inflammatory changes, but immunohistochemistry was positive for HSV protein, and HSV deoxyribonucleic acid (DNA) was recovered from formalin-fixed paraffin-embedded brain tissue. The temporal proximity of the surgery, chemotherapy, and radiotherapy to the onset of disease suggests that these factors may have acted as triggers that precipitated conversion of latent HSV to overt HSV.

The Natural History of Recurrent Herpes Simplex Labialis

1977 ◽  
Vol 297 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Spotswood L. Spruance ◽  
James C. Overall ◽  
Earl R. Kern ◽  
Gerald G. Krueger ◽  
Victoria Pliam ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Natural History ◽  
Recurrent Herpes ◽  
History Of

scholarly journals Immune adherence hemagglutination test applied to the study of herpes simplex and varicella-zoster virus infections

1978 ◽  
Vol 7 (2) ◽  
pp. 114-117
Author(s):  
A Gillani ◽  
L Spence
Keyword(s):  
Herpes Simplex ◽  
Varicella Zoster Virus ◽  
Antibody Titer ◽  
Comparative Studies ◽  
Complement Fixation ◽  
Virus Infections ◽  
Varicella Zoster ◽  
Immune Adherence ◽  
History Of ◽  
Low Levels

The immune adherence hemagglutination (IAHA) test has been used successfully to detect antibody to herpes simplex (HS) virus and varicella-zoster (V-Z) virus. Comparative studies between the complement-fixation (CF) test and the IAHA test revealed that, in most cases, the IAHA test was more sensitive than the CF test. Furthermore, diagnosis on the basis of a fourfold change in antibody titer was made more rapidly by the IAHA test. The IAHA test was found to be a very simple and practical technique requiring only a few hours for completion compared with the conventional CF test which required up to 24 h. In addition, both sera and cerebrospinal fluids could be tested in very low dilutions in the IAHA test, so that very low levels of antibody could be detected. Also, the IAHA test detected antibody to V-Z virus more frequently than did the CF test in adults with a history of varicella occurring 9 to 30 years prior to sampling. The level of cross-reaction between HS and V-Z viruses was examined by both the CF test and the IAHA test, and no major differences between the two techniques were found.

scholarly journals Ancient recombination events between human herpes simplex viruses

2016 ◽  
Author(s):  
Sonia Burrel ◽  
David Boutolleau ◽  
Diane Ryu ◽  
Henri Agut ◽  
Kevin Merkel ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Sub Saharan Africa ◽  
Herpes Simplex Viruses ◽  
Genome Wide ◽  
History Of ◽  
Functional Consequences ◽  
Sub Saharan ◽  
Phylogenomic Analyses ◽  
Close Relatives ◽  
Hsv 1

AbstractHerpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to date comprise HSV-1 fragments. Using phylogenomic analyses, we could also show that two main HSV-2 lineages exist. One lineage is mostly restricted to sub-Saharan Africa while the other has reached a global distribution. Interestingly, only the worldwide lineage is characterized by ancient recombination events with HSV-1. Our findings highlight the complexity of HSV-2 evolution, a virus of likely zoonotic origin which later recombined with its human-adapted relative. They also suggest that co-infections with HSV-1 and 2 may have genomic and potentially functional consequences and should therefore be monitored more closely.

scholarly journals IL28B Genetic Variations in Patients with Recurrent Herpes Simplex Keratitis

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 642 ◽  
Author(s):  
Savić Borivoje ◽  
Stanojlović Svetlana ◽  
Hadži-Milić Milan ◽  
Đonović Nela ◽  
Milošević-Đorđević Olivera ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Il28b Genotype ◽  
Host Genotype ◽  
Nerve Branch ◽  
Corneal Scarring ◽  
Viral Shedding ◽  
Recurrent Herpes ◽  
History Of ◽  
Herpes Simplex Keratitis ◽  
Hsv 1

Background and objectives: Recurrent herpes simplex keratitis (HSK) is the most common cause of corneal blindness in the developed world. A relationship between host gene polymorphisms and the recurrence of herpes simplex virus (HSV) infection has previously been proposed. Thus, the aim of this study was to investigate a potential association between the IL28B host genotype and recurrent HSK. Materials and Methods: Eighty patients older than 18 years of age of both genders with a history of recurrent herpes simplex labialis (HSL) were considered for inclusion. Seventy-five of these patients were found to be seropositive for HSV-1 and were subsequently enrolled in the study. Twenty-four of the enrolled patients also had a history of recurrent HSK associated with severe corneal scarring and visual acuity deterioration. Total DNA was isolated from whole blood samples. A single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene on chromosome 19 was genotyped. Results: A significant association was observed between recurrent HSK and two SNPs of the IL28B genotype (CCrs12979860 and CTrs12979860, p < 0.01). The variation CCrs12979860 showed a significantly greater association with HSK (16 out of 26 patients) compared with CTrs12979860 (8 out of 34 patients). Conclusion: Seropositive individuals with a history of recurrent HSK are likely to have the CC IL28B genotype. This genotype may be related to incomplete control of the infection and more frequent periodical viral shedding along the first nerve branch of the trigeminal ganglion, which clinically manifests as recurrent herpes keratitis. The clinical manifestation of recurrent HSV-1 infection seems to be influenced by polymorphism of the IL28B genotype.

scholarly journals HERPES ASSOCIATED-ERYTHEMA MULTIFORME (HAEM) IN YOUNG ADULT

2018 ◽  
Vol 5 (2) ◽  
pp. 152
Author(s):  
Lukman Hakim Hidayat
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Young Adult ◽  
Female Patient ◽  
Erythema Multiforme ◽  
Cutaneous Lesion ◽  
Mucosal Disease ◽  
Recurrent Herpes ◽  
History Of ◽  
Simplex Virus

Background: Erythema multiforme is an acute and a self-limiting mucocutaneoushypersensitivity reaction triggered by infections and medications. The mostcommon predisposing factors for erythema multiforme is infection with herpessimplex virus. Herpes associated erythema multiforme (HAEM) is an acuteexudative dermatic and mucosal disease caused by the infecting herpes simplexvirus. Most common ages is in childhood.Case and management: We report a case of recurrent herpes-associatederythema multiforme in a 23-year-old female patient, with crustae lesion in thelips and in pain. The patient had history of HSV infection. The patient had afever and prodromal before the lesion emerge. And the cutaneous lesion wasmistaken with the pimpleacne.Conclusions: Although the etiology of EM is still often unknown, infections withherpes simplex virus have been implicated as common predisposing a possibleprecipitating factor. This case illustrates the association of the occurrence of EMwith a herpes simplex virus (HSV) infection and how to managed the lesion

Population Genetics ofCaenorhabditis elegans: The Paradox of Low Polymorphism in a Widespread Species

Genetics ◽  
2003 ◽  
Vol 163 (1) ◽  
pp. 147-157 ◽  
Author(s):  
Arjun Sivasundar ◽  
Jody Hey
Keyword(s):  
Genetic Variation ◽  
Microsatellite Loci ◽  
Population Expansion ◽  
Widespread Species ◽  
C Elegans ◽  
Model Research ◽  
The World ◽  
Natural Isolates ◽  
History Of ◽  
Low Levels

AbstractCaenorhabditis elegans has become one of the most widely used model research organisms, yet we have little information on evolutionary processes and recent evolutionary history of this widespread species. We examined patterns of variation at 20 microsatellite loci in a sample of 23 natural isolates of C. elegans from various parts of the world. One-half of the loci were monomorphic among all strains, and overall genetic variation at microsatellite loci was low, relative to most other species. Some population structure was detected, but there was no association between the genetic and geographic distances among different natural isolates. Thus, despite the nearly worldwide occurrence of C. elegans, little evidence was found for local adaptation in strains derived from different parts of the world. The low levels of genetic variation within and among populations suggest that recent colonization and population expansion might have occurred. However, the patterns of variation are not consistent with population expansion. A possible explanation for the observed patterns is the action of background selection to reduce polymorphism, coupled with ongoing gene flow among populations worldwide.

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